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An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.
Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, Yebra M, Mielgo A, Lowy AM, Husain H, Cascone T, Diao L, Wang J, Wistuba II, Heymach JV, Lippman SM, Desgrosellier JS, Anand S, Weis SM, Cheresh DA. Seguin L, et al. Among authors: desgrosellier js. Nat Cell Biol. 2014 May;16(5):457-68. doi: 10.1038/ncb2953. Epub 2014 Apr 20. Nat Cell Biol. 2014. PMID: 24747441 Free PMC article.
Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers.
Seguin L, Camargo MF, Wettersten HI, Kato S, Desgrosellier JS, von Schalscha T, Elliott KC, Cosset E, Lesperance J, Weis SM, Cheresh DA. Seguin L, et al. Among authors: desgrosellier js. Cancer Discov. 2017 Dec;7(12):1464-1479. doi: 10.1158/2159-8290.CD-17-0539. Epub 2017 Sep 11. Cancer Discov. 2017. PMID: 28893801 Free PMC article.
Oncogenic Ras/Src cooperativity in pancreatic neoplasia.
Shields DJ, Murphy EA, Desgrosellier JS, Mielgo A, Lau SK, Barnes LA, Lesperance J, Huang M, Schmedt C, Tarin D, Lowy AM, Cheresh DA. Shields DJ, et al. Among authors: desgrosellier js. Oncogene. 2011 May 5;30(18):2123-34. doi: 10.1038/onc.2010.589. Epub 2011 Jan 17. Oncogene. 2011. PMID: 21242978 Free PMC article.
EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation.
Huang M, Anand S, Murphy EA, Desgrosellier JS, Stupack DG, Shattil SJ, Schlaepfer DD, Cheresh DA. Huang M, et al. Among authors: desgrosellier js. Oncogene. 2012 May 31;31(22):2783-93. doi: 10.1038/onc.2011.450. Epub 2011 Oct 3. Oncogene. 2012. PMID: 21963850 Free PMC article.
RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia.
Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA. Shields DJ, et al. Among authors: desgrosellier js. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2189-94. doi: 10.1073/pnas.0911646107. Epub 2009 Dec 28. Proc Natl Acad Sci U S A. 2010. PMID: 20080647 Free PMC article.
PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes.
Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. Garmy-Susini B, et al. Among authors: desgrosellier js. Proc Natl Acad Sci U S A. 2013 May 28;110(22):9042-7. doi: 10.1073/pnas.1219603110. Epub 2013 May 13. Proc Natl Acad Sci U S A. 2013. PMID: 23671068 Free PMC article.
23 results