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TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis.
Deshaies JE, Shkreta L, Moszczynski AJ, Sidibé H, Semmler S, Fouillen A, Bennett ER, Bekenstein U, Destroismaisons L, Toutant J, Delmotte Q, Volkening K, Stabile S, Aulas A, Khalfallah Y, Soreq H, Nanci A, Strong MJ, Chabot B, Vande Velde C. Deshaies JE, et al. Brain. 2018 May 1;141(5):1320-1333. doi: 10.1093/brain/awy062. Brain. 2018. PMID: 29562314 Free PMC article.
Reply: TDP-43 mutations increase HNRNP A1-7B through gain of splicing function.
Tétreault M, Deshaies JE, Semmler S, Sidibé H, Shkreta L, Volkening K, Soreq H, Strong MJ, Chabot B, Vande Velde C. Tétreault M, et al. Among authors: deshaies je. Brain. 2018 Dec 1;141(12):e84. doi: 10.1093/brain/awy261. Brain. 2018. PMID: 30364932 Free PMC article. No abstract available.
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia.
Sidibé H, Khalfallah Y, Xiao S, Gómez NB, Fakim H, Tank EMH, Di Tomasso G, Bareke E, Aulas A, McKeever PM, Melamed Z, Destroimaisons L, Deshaies JE, Zinman L, Parker JA, Legault P, Tétreault M, Barmada SJ, Robertson J, Vande Velde C. Sidibé H, et al. Among authors: deshaies je. Brain. 2021 Dec 16;144(11):3461-3476. doi: 10.1093/brain/awab217. Brain. 2021. PMID: 34115105 Free PMC article.
hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated.
Gagné M, Deshaies JE, Sidibé H, Benchaar Y, Arbour D, Dubinski A, Litt G, Peyrard S, Robitaille R, Sephton CF, Vande Velde C. Gagné M, et al. Among authors: deshaies je. Front Neurosci. 2021 Sep 24;15:724307. doi: 10.3389/fnins.2021.724307. eCollection 2021. Front Neurosci. 2021. PMID: 34630013 Free PMC article.