Deshmukh L - Search Results

1

Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator.

Miller Jenkins LM, Paine EL, Deshmukh L, Nikolayevskiy H, Lyons GC, Scerba MT, George Rosenker K, Luecke HF, Louis JM, Chertova E, Gorelick RJ, Ott DE, Clore GM, Appella DH. Miller Jenkins LM, et al. Among authors: deshmukh l. J Am Chem Soc. 2019 May 22;141(20):8327-8338. doi: 10.1021/jacs.9b02743. Epub 2019 May 13. J Am Chem Soc. 2019. PMID: 31042030 Free PMC article.

2

Structure and dynamics of full-length HIV-1 capsid protein in solution.

Deshmukh L, Schwieters CD, Grishaev A, Ghirlando R, Baber JL, Clore GM. Deshmukh L, et al. J Am Chem Soc. 2013 Oct 30;135(43):16133-47. doi: 10.1021/ja406246z. Epub 2013 Oct 17. J Am Chem Soc. 2013. PMID: 24066695 Free PMC article.

3

Investigation of the structure and dynamics of the capsid-spacer peptide 1-nucleocapsid fragment of the HIV-1 gag polyprotein by solution NMR spectroscopy.

Deshmukh L, Ghirlando R, Clore GM. Deshmukh L, et al. Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1025-8. doi: 10.1002/anie.201309127. Epub 2013 Dec 11. Angew Chem Int Ed Engl. 2014. PMID: 24338988 Free PMC article.

4

Conformation and dynamics of the Gag polyprotein of the human immunodeficiency virus 1 studied by NMR spectroscopy.

Deshmukh L, Ghirlando R, Clore GM. Deshmukh L, et al. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3374-9. doi: 10.1073/pnas.1501985112. Epub 2015 Feb 23. Proc Natl Acad Sci U S A. 2015. PMID: 25713345 Free PMC article.

5

Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease.

Louis JM, Deshmukh L, Sayer JM, Aniana A, Clore GM. Louis JM, et al. Among authors: deshmukh l. Biochemistry. 2015 Sep 8;54(35):5414-24. doi: 10.1021/acs.biochem.5b00759. Epub 2015 Aug 21. Biochemistry. 2015. PMID: 26266692 Free PMC article.

6

Quantitative Characterization of Configurational Space Sampled by HIV-1 Nucleocapsid Using Solution NMR, X-ray Scattering and Protein Engineering.

Deshmukh L, Schwieters CD, Grishaev A, Clore GM. Deshmukh L, et al. Chemphyschem. 2016 Jun 3;17(11):1548-52. doi: 10.1002/cphc.201600212. Epub 2016 Mar 16. Chemphyschem. 2016. PMID: 26946052 Free PMC article.

7

Transient HIV-1 Gag-protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations.

Deshmukh L, Louis JM, Ghirlando R, Clore GM. Deshmukh L, et al. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12456-12461. doi: 10.1073/pnas.1615342113. Epub 2016 Oct 17. Proc Natl Acad Sci U S A. 2016. PMID: 27791180 Free PMC article.

8

Binding kinetics and substrate selectivity in HIV-1 protease-Gag interactions probed at atomic resolution by chemical exchange NMR.

Deshmukh L, Tugarinov V, Louis JM, Clore GM. Deshmukh L, et al. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9855-E9862. doi: 10.1073/pnas.1716098114. Epub 2017 Oct 30. Proc Natl Acad Sci U S A. 2017. PMID: 29087351 Free PMC article.

9

Targeting a Dark Excited State of HIV-1 Nucleocapsid by Antiretroviral Thioesters Revealed by NMR Spectroscopy.

Deshmukh L, Tugarinov V, Appella DH, Clore GM. Deshmukh L, et al. Angew Chem Int Ed Engl. 2018 Mar 1;57(10):2687-2691. doi: 10.1002/anie.201713172. Epub 2018 Feb 2. Angew Chem Int Ed Engl. 2018. PMID: 29345807 Free PMC article.

10

Avidity-Based Method for the Efficient Generation of Monoubiquitinated Recombinant Proteins.

Nelson SL, Li Y, Chen Y, Deshmukh L. Nelson SL, et al. Among authors: deshmukh l. J Am Chem Soc. 2023 Apr 12;145(14):7748-7752. doi: 10.1021/jacs.3c01943. Epub 2023 Apr 3. J Am Chem Soc. 2023. PMID: 37010382 Free PMC article.

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