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Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair.
Myler LR, Gallardo IF, Soniat MM, Deshpande RA, Gonzalez XB, Kim Y, Paull TT, Finkelstein IJ. Myler LR, et al. Among authors: deshpande ra. Mol Cell. 2017 Sep 7;67(5):891-898.e4. doi: 10.1016/j.molcel.2017.08.002. Epub 2017 Aug 31. Mol Cell. 2017. PMID: 28867292 Free PMC article.
Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.
Myler LR, Soniat MM, Zhang X, Deshpande RA, Paull TT, Finkelstein IJ. Myler LR, et al. Among authors: deshpande ra. Methods Mol Biol. 2019;2004:269-287. doi: 10.1007/978-1-4939-9520-2_20. Methods Mol Biol. 2019. PMID: 31147924 Free PMC article.
Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast.
Arora S, Deshpande RA, Budd M, Campbell J, Revere A, Zhang X, Schmidt KH, Paull TT. Arora S, et al. Among authors: deshpande ra. Mol Cell Biol. 2017 Nov 28;37(24):e00156-17. doi: 10.1128/MCB.00156-17. Print 2017 Dec 15. Mol Cell Biol. 2017. PMID: 28970327 Free PMC article.
Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.
Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H. Hoa NN, et al. Mol Cell. 2016 Nov 3;64(3):580-592. doi: 10.1016/j.molcel.2016.10.011. Mol Cell. 2016. PMID: 27814490
Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.
Makharashvili N, Tubbs AT, Yang SH, Wang H, Barton O, Zhou Y, Deshpande RA, Lee JH, Lobrich M, Sleckman BP, Wu X, Paull TT. Makharashvili N, et al. Mol Cell. 2014 Jun 19;54(6):1022-33. doi: 10.1016/j.molcel.2014.04.011. Epub 2014 May 15. Mol Cell. 2014. PMID: 24837676 Free PMC article.
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT. Lee JH, et al. J Biol Chem. 2013 May 3;288(18):12840-51. doi: 10.1074/jbc.M113.460378. Epub 2013 Mar 22. J Biol Chem. 2013. PMID: 23525106 Free PMC article.
ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT. Deshpande RA, et al. EMBO J. 2014 Mar 3;33(5):482-500. doi: 10.1002/embj.201386100. Epub 2014 Feb 3. EMBO J. 2014. PMID: 24493214 Free PMC article.
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