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Blood pressure and cardiovascular risk: what about cocoa and chocolate?
Grassi D, Desideri G, Ferri C. Grassi D, et al. Arch Biochem Biophys. 2010 Sep 1;501(1):112-5. doi: 10.1016/j.abb.2010.05.020. Epub 2010 Jun 1. Arch Biochem Biophys. 2010. PMID: 20494650 Review.
Angiotensin II inhibits endothelial cell motility through an AT1-dependent oxidant-sensitive decrement of nitric oxide availability.
Desideri G, Bravi MC, Tucci M, Croce G, Marinucci MC, Santucci A, Alesse E, Ferri C. Desideri G, et al. Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1218-23. doi: 10.1161/01.ATV.0000078521.51319.65. Epub 2003 May 22. Arterioscler Thromb Vasc Biol. 2003. PMID: 12763763
Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage.
Bocchio M, Desideri G, Scarpelli P, Necozione S, Properzi G, Spartera C, Francavilla F, Ferri C, Francavilla S. Bocchio M, et al. J Urol. 2004 Apr;171(4):1601-4. doi: 10.1097/01.ju.0000116325.06572.85. J Urol. 2004. PMID: 15017230
Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons.
Grassi D, Lippi C, Necozione S, Desideri G, Ferri C. Grassi D, et al. Am J Clin Nutr. 2005 Mar;81(3):611-4. doi: 10.1093/ajcn/81.3.611. Am J Clin Nutr. 2005. PMID: 15755830 Clinical Trial.
DESIGN: After a 7-d cocoa-free run-in phase, 15 healthy subjects were randomly assigned to receive for 15 d either 100 g dark chocolate bars, which contained approximately 500 mg polyphenols, or 90 g white chocolate bars, which presumably contained no polyphenols. . …
DESIGN: After a 7-d cocoa-free run-in phase, 15 healthy subjects were randomly assigned to receive for 15 d either 100 g dark chocola …
Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives.
Grassi D, Necozione S, Lippi C, Croce G, Valeri L, Pasqualetti P, Desideri G, Blumberg JB, Ferri C. Grassi D, et al. Hypertension. 2005 Aug;46(2):398-405. doi: 10.1161/01.HYP.0000174990.46027.70. Epub 2005 Jul 18. Hypertension. 2005. PMID: 16027246 Clinical Trial.
After a 7-day chocolate-free run-in phase, 20 never-treated, grade I patients with EH (10 males; 43.7+/-7.8 years) were randomized to receive either 100 g per day DC (containing 88 mg flavanols) or 90 g per day flavanol-free white chocolate (WC) in an isocaloric man …
After a 7-day chocolate-free run-in phase, 20 never-treated, grade I patients with EH (10 males; 43.7+/-7.8 years) were randomized to receiv …
Inhibition of phosphodiesterase type 5 with tadalafil is associated to an improved activity of circulating angiogenic cells in men with cardiovascular risk factors and erectile dysfunction.
Bocchio M, Pelliccione F, Passaquale G, Mihalca R, Necozione S, Desideri G, Francavilla F, Ferri C, Francavilla S. Bocchio M, et al. Atherosclerosis. 2008 Jan;196(1):313-319. doi: 10.1016/j.atherosclerosis.2006.09.035. Epub 2006 Dec 5. Atherosclerosis. 2008. PMID: 17150221 Clinical Trial.
Enhanced plasma soluble CD40 ligand levels in essential hypertensive patients with blunted nocturnal blood pressure decrease.
Desideri G, Cipollone F, Valeri L, Grassi D, Necozione S, Croce G, Passacquale G, Garofalo A, Lippi C, Mezzetti A, Ferri C. Desideri G, et al. Am J Hypertens. 2007 Jan;20(1):70-6; discussion 77. doi: 10.1016/j.amjhyper.2006.06.007. Am J Hypertens. 2007. PMID: 17198914
Nifedipine improves the migratory ability of circulating endothelial progenitor cells depending on manganese superoxide dismutase upregulation.
Passacquale G, Desideri G, Croce G, Murgo S, Mancarelli MM, Zazzeroni F, Alesse E, Ferri C. Passacquale G, et al. J Hypertens. 2008 Apr;26(4):737-46. doi: 10.1097/HJH.0b013e3282f4d1bd. J Hypertens. 2008. PMID: 18327084
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