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46 results

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Heparin-induced thrombocytopenia.
Arepally GM. Arepally GM. Blood. 2017 May 25;129(21):2864-2872. doi: 10.1182/blood-2016-11-709873. Epub 2017 Apr 17. Blood. 2017. PMID: 28416511 Free PMC article. Review.
It is now recognized that anti-PF4/heparin antibodies develop commonly after heparin exposure, but only a subset of sensitized patients progress to life-threatening complications of thrombocytopenia and thrombosis. Recent scientific developments have clarified mecha …
It is now recognized that anti-PF4/heparin antibodies develop commonly after heparin exposure, but only a subset of sensitized …
Determinants of PF4/heparin immunogenicity.
Suvarna S, Espinasse B, Qi R, Lubica R, Poncz M, Cines DB, Wiesner MR, Arepally GM. Suvarna S, et al. Blood. 2007 Dec 15;110(13):4253-60. doi: 10.1182/blood-2007-08-105098. Epub 2007 Sep 11. Blood. 2007. PMID: 17848616 Free PMC article.
HIT antibodies preferentially recognize large macromolecular complexes formed between PF4 and heparin over a narrow range of molar ratios, but the biophysical properties of complexes that initiate antibody production are unknown. To identify structural determinants underly …
HIT antibodies preferentially recognize large macromolecular complexes formed between PF4 and heparin over a narrow range of molar ratios, b …
Heparin-induced thrombocytopenia.
Greinacher A, Althaus K, Krauel K, Selleng S. Greinacher A, et al. Hamostaseologie. 2010 Jan;30(1):17-8, 20-8. Hamostaseologie. 2010. PMID: 20162249 Review.
Heparin-induced thrombocytopenia (HIT), typically occurring in the second week of heparin therapy, is an antibody-mediated adverse drug reaction associated with increased thrombotic risk. The most important antigens are located on platelet factor 4 (PF4)/heparin …
Heparin-induced thrombocytopenia (HIT), typically occurring in the second week of heparin therapy, is an antibody-mediated adverse drug reac …
Management of heparin-induced thrombocytopenia.
Warkentin TE, Greinacher A. Warkentin TE, et al. Curr Opin Hematol. 2016 Sep;23(5):462-70. doi: 10.1097/MOH.0000000000000273. Curr Opin Hematol. 2016. PMID: 27380556 Review.
HIT has features of both B-cell and T-cell immune responses; uptake of PF4/heparin complexes into macrophages ('macropinocytosis') facilitates the anti-PF4/heparin immune response. ...
HIT has features of both B-cell and T-cell immune responses; uptake of PF4/heparin complexes into macrophages ('macropinocytos …
Reduced induction of anti-PF4/heparin antibody in RA patients after total knee arthroplasty.
Izumi M, Sakai T, Shirakawa A, Kozuru H, Jiuchi Y, Izumi Y, Asahara T, Kumagai K, Mawatari M, Osaki M, Motokawa S, Migita K. Izumi M, et al. Arthritis Res Ther. 2016 Aug 25;18(1):191. doi: 10.1186/s13075-016-1090-2. Arthritis Res Ther. 2016. PMID: 27558507 Free PMC article. Clinical Trial.
RESULTS: The rates of seroconversion to anti-PF4/heparin Ab were lower in RA patients (4.0 %) than in OA patients (25.5 %). The anti-PF4/heparin IgG optical density (OD) values did not differ before and after surgery in RA patients. ...The titers of an …
RESULTS: The rates of seroconversion to anti-PF4/heparin Ab were lower in RA patients (4.0 %) than in OA patients (25.5 %). Th …
New insights into the binding of PF4 to long heparin oligosaccharides in ultralarge complexes using mass spectrometry.
Shi D, Zhao H, Bu C, Fraser K, Wang H, Dordick JS, Linhardt RJ, Zhang F, Shi F, Chi L. Shi D, et al. J Thromb Haemost. 2023 Dec;21(12):3608-3618. doi: 10.1016/j.jtha.2023.08.020. Epub 2023 Aug 28. J Thromb Haemost. 2023. PMID: 37648114 Free article.
OBJECTIVES: We aim at characterizing the interaction between PF4 and long-chain heparin oligosaccharides and providing robust analytical methods for the analysis of PF4-heparin complexes. METHODS: In this work, the characteristics of PF4-enoxaparin complexes …
OBJECTIVES: We aim at characterizing the interaction between PF4 and long-chain heparin oligosaccharides and providing robust analytical met …
HIT: lessons learned.
Warkentin TE. Warkentin TE. Pathophysiol Haemost Thromb. 2006;35(1-2):50-7. doi: 10.1159/000093544. Pathophysiol Haemost Thromb. 2006. PMID: 16855347 Review.
Unusual immunologic features of HIT, such as the dissociation between immunogenicity (induction of immune response) and cross-reactivity (capacity to form the antigens recognized by HIT antibodies)of the implicated polysaccharide anticoagulants, and the generally ra …
Unusual immunologic features of HIT, such as the dissociation between immunogenicity (induction of immune response) and cross-reactiv …
Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia.
Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB. Cai Z, et al. J Thromb Haemost. 2023 Mar;21(3):652-666. doi: 10.1016/j.jtha.2022.11.043. Epub 2022 Dec 22. J Thromb Haemost. 2023. PMID: 36696211 Free article.
Contemporary anti-thrombotic therapy for HIT is neither entirely safe nor entirely successful and acts downstream of ULIC formation and Fcgamma receptor-initiated generation of thrombin. OBJECTIVES: To determine whether HIT antigen and ULIC formation and stability could be …
Contemporary anti-thrombotic therapy for HIT is neither entirely safe nor entirely successful and acts downstream of ULIC formation and Fcga …
Role of anti-PF4/heparin antibodies in recurrent thrombotic events after acute coronary syndromes.
Mascelli MA, Deliargyris EN, Damaraju LV, Barnathan ES, Sane DC. Mascelli MA, et al. Semin Thromb Hemost. 2004 Jun;30(3):347-50. doi: 10.1055/s-2004-831047. Semin Thromb Hemost. 2004. PMID: 15282657 Clinical Trial.
Twenty-three of 218 patients (10.6%) had anti-PF4/heparin antibodies. Patients with anti-PF4/heparin were more likely to have death or MI (30.4% vs. 11.3%, p = 0.011) or MI (21.7% vs. 6.2%, p = 0.008) than patients who were negative for the antibody. . …
Twenty-three of 218 patients (10.6%) had anti-PF4/heparin antibodies. Patients with anti-PF4/heparin were more l …
Spontaneous HIT syndrome: Knee replacement, infection, and parallels with vaccine-induced immune thrombotic thrombocytopenia.
Warkentin TE, Greinacher A. Warkentin TE, et al. Thromb Res. 2021 Aug;204:40-51. doi: 10.1016/j.thromres.2021.05.018. Epub 2021 Jun 9. Thromb Res. 2021. PMID: 34144250 Free article. Review.
Heparin-induced thrombocytopenia (HIT) is characterized clinically by thrombocytopenia, hypercoagulability, and increased thrombosis risk, and serologically by platelet-activating anti-platelet factor 4 (PF4)/heparin antibodies. Heparin-"induced" acknowledges that H …
Heparin-induced thrombocytopenia (HIT) is characterized clinically by thrombocytopenia, hypercoagulability, and increased thrombosis risk, a …
46 results