Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 2
1998 1
1999 1
2001 1
2002 1
2004 1
2005 2
2006 4
2007 1
2008 1
2009 2
2010 3
2011 1
2012 1
2013 2
2014 2
2015 3
2016 4
2017 2
2018 3
2019 2
2020 1
2021 6
2022 1
2023 2
2024 1
2025 4
2026 2

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

51 results

Results by year

Citations

1 article found by citation matching

Search results

Filters applied: . Clear all
Page 1
Heparin-induced thrombocytopenia.
Arepally GM. Arepally GM. Blood. 2017 May 25;129(21):2864-2872. doi: 10.1182/blood-2016-11-709873. Epub 2017 Apr 17. Blood. 2017. PMID: 28416511 Free PMC article. Review.
It is now recognized that anti-PF4/heparin antibodies develop commonly after heparin exposure, but only a subset of sensitized patients progress to life-threatening complications of thrombocytopenia and thrombosis. Recent scientific developments have clarified mecha …
It is now recognized that anti-PF4/heparin antibodies develop commonly after heparin exposure, but only a subset of sensitized …
Determinants of PF4/heparin immunogenicity.
Suvarna S, Espinasse B, Qi R, Lubica R, Poncz M, Cines DB, Wiesner MR, Arepally GM. Suvarna S, et al. Blood. 2007 Dec 15;110(13):4253-60. doi: 10.1182/blood-2007-08-105098. Epub 2007 Sep 11. Blood. 2007. PMID: 17848616 Free PMC article.
HIT antibodies preferentially recognize large macromolecular complexes formed between PF4 and heparin over a narrow range of molar ratios, but the biophysical properties of complexes that initiate antibody production are unknown. To identify structural determinants underly …
HIT antibodies preferentially recognize large macromolecular complexes formed between PF4 and heparin over a narrow range of molar ratios, b …
Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia.
Treverton J, Arnold DM, Ivanov DG, Ivetic N, Zhang Y, Ali HA, Clare R, Kaltashov IA, Kelton JG, Nazy I. Treverton J, et al. N Engl J Med. 2025 Sep 4;393(9):879-886. doi: 10.1056/NEJMoa2507175. N Engl J Med. 2025. PMID: 40902162 Free PMC article.
METHODS: In this study, we investigated the clonality of pathogenic HIT antibodies. Antibodies against PF4-heparin were affinity-purified with the use of PF4-heparin beads from serum samples obtained from nine patients with clinically and serologically …
METHODS: In this study, we investigated the clonality of pathogenic HIT antibodies. Antibodies against PF4-heparin were affini …
Non-PF4/heparin-binding, platelet-activating antibodies in heparin-induced thrombocytopenia.
Zhou L, Cao A, Zhu W, Villalobos-Garcia D, Marchan M, Curtis B, Rauova L, Poncz M, Aster R, Padmanabhan A, Wang D, Wen R. Zhou L, et al. Blood. 2026 Jul 2;148(1):115-129. doi: 10.1182/blood.2025032317. Blood. 2026. PMID: 42013023 Free PMC article.
The hallmark of heparin-induced thrombocytopenia (HIT) is the presence of immunoglobulin G (IgG) antibodies against platelet factor 4/heparin (PF4/H) complexes, typically detected by PF4/H enzyme-linked immunosorbent assay (ELISA); thus, negative ELISA results are c …
The hallmark of heparin-induced thrombocytopenia (HIT) is the presence of immunoglobulin G (IgG) antibodies against platelet factor 4/hep …
Heparin-induced thrombocytopenia.
Greinacher A, Althaus K, Krauel K, Selleng S. Greinacher A, et al. Hamostaseologie. 2010 Jan;30(1):17-8, 20-8. Hamostaseologie. 2010. PMID: 20162249 Review.
Heparin-induced thrombocytopenia (HIT), typically occurring in the second week of heparin therapy, is an antibody-mediated adverse drug reaction associated with increased thrombotic risk. The most important antigens are located on platelet factor 4 (PF4)/heparin …
Heparin-induced thrombocytopenia (HIT), typically occurring in the second week of heparin therapy, is an antibody-mediated adverse drug reac …
Management of heparin-induced thrombocytopenia.
Warkentin TE, Greinacher A. Warkentin TE, et al. Curr Opin Hematol. 2016 Sep;23(5):462-70. doi: 10.1097/MOH.0000000000000273. Curr Opin Hematol. 2016. PMID: 27380556 Review.
HIT has features of both B-cell and T-cell immune responses; uptake of PF4/heparin complexes into macrophages ('macropinocytosis') facilitates the anti-PF4/heparin immune response. ...
HIT has features of both B-cell and T-cell immune responses; uptake of PF4/heparin complexes into macrophages ('macropinocytos …
New insights into the binding of PF4 to long heparin oligosaccharides in ultralarge complexes using mass spectrometry.
Shi D, Zhao H, Bu C, Fraser K, Wang H, Dordick JS, Linhardt RJ, Zhang F, Shi F, Chi L. Shi D, et al. J Thromb Haemost. 2023 Dec;21(12):3608-3618. doi: 10.1016/j.jtha.2023.08.020. Epub 2023 Aug 28. J Thromb Haemost. 2023. PMID: 37648114 Free article.
OBJECTIVES: We aim at characterizing the interaction between PF4 and long-chain heparin oligosaccharides and providing robust analytical methods for the analysis of PF4-heparin complexes. METHODS: In this work, the characteristics of PF4-enoxaparin complexes …
OBJECTIVES: We aim at characterizing the interaction between PF4 and long-chain heparin oligosaccharides and providing robust analytical met …
Reduced induction of anti-PF4/heparin antibody in RA patients after total knee arthroplasty.
Izumi M, Sakai T, Shirakawa A, Kozuru H, Jiuchi Y, Izumi Y, Asahara T, Kumagai K, Mawatari M, Osaki M, Motokawa S, Migita K. Izumi M, et al. Arthritis Res Ther. 2016 Aug 25;18(1):191. doi: 10.1186/s13075-016-1090-2. Arthritis Res Ther. 2016. PMID: 27558507 Free PMC article. Clinical Trial.
RESULTS: The rates of seroconversion to anti-PF4/heparin Ab were lower in RA patients (4.0 %) than in OA patients (25.5 %). The anti-PF4/heparin IgG optical density (OD) values did not differ before and after surgery in RA patients. ...The titers of an …
RESULTS: The rates of seroconversion to anti-PF4/heparin Ab were lower in RA patients (4.0 %) than in OA patients (25.5 %). Th …
HIT: lessons learned.
Warkentin TE. Warkentin TE. Pathophysiol Haemost Thromb. 2006;35(1-2):50-7. doi: 10.1159/000093544. Pathophysiol Haemost Thromb. 2006. PMID: 16855347 Review.
Unusual immunologic features of HIT, such as the dissociation between immunogenicity (induction of immune response) and cross-reactivity (capacity to form the antigens recognized by HIT antibodies)of the implicated polysaccharide anticoagulants, and the generally ra …
Unusual immunologic features of HIT, such as the dissociation between immunogenicity (induction of immune response) and cross-reactiv …
Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia.
Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB. Cai Z, et al. J Thromb Haemost. 2023 Mar;21(3):652-666. doi: 10.1016/j.jtha.2022.11.043. Epub 2022 Dec 22. J Thromb Haemost. 2023. PMID: 36696211 Free article.
Contemporary anti-thrombotic therapy for HIT is neither entirely safe nor entirely successful and acts downstream of ULIC formation and Fcgamma receptor-initiated generation of thrombin. OBJECTIVES: To determine whether HIT antigen and ULIC formation and stability could be …
Contemporary anti-thrombotic therapy for HIT is neither entirely safe nor entirely successful and acts downstream of ULIC formation and Fcga …
51 results