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Development of a 3D matrix for modeling mammalian spinal cord injury in vitro.
Diaz Quiroz JF, Li Y, Aparicio C, Echeverri K. Diaz Quiroz JF, et al. Neural Regen Res. 2016 Nov;11(11):1810-1815. doi: 10.4103/1673-5374.194751. Neural Regen Res. 2016. PMID: 28123426 Free PMC article.
Spinal cord injury is usually modeled in rats and mice using contusion or complete transection models and this has led to a deeper understanding of the molecular and cellular complexities of the injury. ...Here we developed a colla
Spinal cord injury is usually modeled in rats and mice using contusion or complete transection models and
Neuroactive Peptide Nanofibers for Regeneration of Spinal Cord after Injury.
Sever-Bahcekapili M, Yilmaz C, Demirel A, Kilinc MC, Dogan I, Caglar YS, Guler MO, Tekinay AB. Sever-Bahcekapili M, et al. Macromol Biosci. 2021 Jan;21(1):e2000234. doi: 10.1002/mabi.202000234. Epub 2020 Oct 11. Macromol Biosci. 2021. PMID: 33043585
The highly complex nature of spinal cord injuries (SCIs) requires design of novel biomaterials that can stimulate cellular regeneration and functional recovery. ...The self-assembling peptide molecules are designed to form nanofibers, which display heparan su …
The highly complex nature of spinal cord injuries (SCIs) requires design of novel biomaterials that can stimulate cellu …
Release of O-GlcNAc transferase inhibitor promotes neuronal differentiation of neural stem cells in 3D bioprinted supramolecular hydrogel scaffold for spinal cord injury repair.
Liu X, Song S, Chen Z, Gao C, Li Y, Luo Y, Huang J, Zhang Z. Liu X, et al. Acta Biomater. 2022 Oct 1;151:148-162. doi: 10.1016/j.actbio.2022.08.031. Epub 2022 Aug 21. Acta Biomater. 2022. PMID: 36002129
Precise fabrication of biomimetic three-dimensional (3D) structure and effective neuronal differentiation under the pathological environment are the key to neural stem cell (NSC)-based spinal cord injury (SCI) therapy. ...The scaffolds with spinal
Precise fabrication of biomimetic three-dimensional (3D) structure and effective neuronal differentiation under the pathological envi …
Engineering biomaterial microenvironments to promote myelination in the central nervous system.
Unal DB, Caliari SR, Lampe KJ. Unal DB, et al. Brain Res Bull. 2019 Oct;152:159-174. doi: 10.1016/j.brainresbull.2019.07.013. Epub 2019 Jul 12. Brain Res Bull. 2019. PMID: 31306690 Review.
Promoting remyelination and/or minimizing demyelination are key therapeutic strategies under investigation for diseases and injuries like multiple sclerosis (MS), spinal cord injury, stroke, and virus-induced encephalopathy. ...In particular, stiffness …
Promoting remyelination and/or minimizing demyelination are key therapeutic strategies under investigation for diseases and injuries
The Evolving Role of Induced Pluripotent Stem Cells and Cerebral Organoids in Treating and Modeling Neurosurgical Diseases.
Jovanovich N, Habib A, Kodavali C, Edwards L, Amankulor N, Zinn PO. Jovanovich N, et al. World Neurosurg. 2021 Nov;155:171-179. doi: 10.1016/j.wneu.2021.08.081. Epub 2021 Aug 25. World Neurosurg. 2021. PMID: 34454068 Review.
Transplantation of IPSCs is being studied in neurological injuries and diseases, such as spinal cord injury and Parkinson's disease, whose clinical manifestations stem from underlying neuronal and/or axonal degeneration. ...Such evidence makes I …
Transplantation of IPSCs is being studied in neurological injuries and diseases, such as spinal cord injury and …
Effective Modulation of CNS Inhibitory Microenvironment using Bioinspired Hybrid-Nanoscaffold-Based Therapeutic Interventions.
Yang L, Conley BM, Cerqueira SR, Pongkulapa T, Wang S, Lee JK, Lee KB. Yang L, et al. Adv Mater. 2020 Oct;32(43):e2002578. doi: 10.1002/adma.202002578. Epub 2020 Sep 6. Adv Mater. 2020. PMID: 32893402 Free PMC article.
By tailoring the structural and biochemical properties of the 3D porous nanoscaffold, enhanced axonal growth from the dual-targeting therapeutic strategy in a human induced pluripotent stem cell (hiPSC)-based in vitro model of neuroinflammation is demo …
By tailoring the structural and biochemical properties of the 3D porous nanoscaffold, enhanced axonal growth from the dual-tar …
Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors.
Jones LL, Tuszynski MH. Jones LL, et al. J Neurosci. 2002 Jun 1;22(11):4611-24. doi: 10.1523/JNEUROSCI.22-11-04611.2002. J Neurosci. 2002. PMID: 12040068 Free PMC article.
Keratan sulfate proteoglycans (KSPGs) are extracellular matrix molecules that appear to establish boundaries for axonal growth in the developing brain and spinal cord. ...The aim of the current study was to investigate whether KSPGs are expresse …
Keratan sulfate proteoglycans (KSPGs) are extracellular matrix molecules that appear to establish boundaries for axonal growth
Evaluation of biomaterials for bladder augmentation using cystometric analyses in various rodent models.
Tu DD, Seth A, Gil ES, Kaplan DL, Mauney JR, Estrada CR Jr. Tu DD, et al. J Vis Exp. 2012 Aug 9;(66):3981. doi: 10.3791/3981. J Vis Exp. 2012. PMID: 22907252 Free PMC article.
A number of congenital and acquired urological anomalies including posterior urethral valves, benign prostatic hyperplasia, and neurogenic bladder secondary to spina bifida/spinal cord injury can result in pathologic tissue remodeling leading to impaired comp …
A number of congenital and acquired urological anomalies including posterior urethral valves, benign prostatic hyperplasia, and neurogenic b …
Influence of cross-linked hyaluronic acid hydrogels on neurite outgrowth and recovery from spinal cord injury.
Horn EM, Beaumont M, Shu XZ, Harvey A, Prestwich GD, Horn KM, Gibson AR, Preul MC, Panitch A. Horn EM, et al. J Neurosurg Spine. 2007 Feb;6(2):133-40. doi: 10.3171/spi.2007.6.2.133. J Neurosurg Spine. 2007. PMID: 17330580
Hyaluronic acid (HA), a nonsulfated glycosaminoglycan ubiquitous in all tissues, was investigated as a potential neural tissue engineering matrix. METHODS: Chick dorsal root ganglia were cultured in 3D hydrogel matrices composed of cross-linked thiol-modified HA or …
Hyaluronic acid (HA), a nonsulfated glycosaminoglycan ubiquitous in all tissues, was investigated as a potential neural tissue engineering …