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Development of a 3D matrix for modeling mammalian spinal cord injury in vitro.
Diaz Quiroz JF, Li Y, Aparicio C, Echeverri K. Diaz Quiroz JF, et al. Neural Regen Res. 2016 Nov;11(11):1810-1815. doi: 10.4103/1673-5374.194751. Neural Regen Res. 2016. PMID: 28123426 Free PMC article.
Spinal cord injury affects millions of people around the world, however, limited therapies are available to improve the quality of life of these patients. Spinal cord injury is usually modeled in rats and mice using contusion or co
Spinal cord injury affects millions of people around the world, however, limited therapies are available to improve the
Neuroactive Peptide Nanofibers for Regeneration of Spinal Cord after Injury.
Sever-Bahcekapili M, Yilmaz C, Demirel A, Kilinc MC, Dogan I, Caglar YS, Guler MO, Tekinay AB. Sever-Bahcekapili M, et al. Macromol Biosci. 2021 Jan;21(1):e2000234. doi: 10.1002/mabi.202000234. Epub 2020 Oct 11. Macromol Biosci. 2021. PMID: 33043585
The highly complex nature of spinal cord injuries (SCIs) requires design of novel biomaterials that can stimulate cellular regeneration and functional recovery. ...The self-assembling peptide molecules are designed to form nanofibers, which display heparan su …
The highly complex nature of spinal cord injuries (SCIs) requires design of novel biomaterials that can stimulate cellu …
Release of O-GlcNAc transferase inhibitor promotes neuronal differentiation of neural stem cells in 3D bioprinted supramolecular hydrogel scaffold for spinal cord injury repair.
Liu X, Song S, Chen Z, Gao C, Li Y, Luo Y, Huang J, Zhang Z. Liu X, et al. Acta Biomater. 2022 Oct 1;151:148-162. doi: 10.1016/j.actbio.2022.08.031. Epub 2022 Aug 21. Acta Biomater. 2022. PMID: 36002129
Precise fabrication of biomimetic three-dimensional (3D) structure and effective neuronal differentiation under the pathological environment are the key to neural stem cell (NSC)-based spinal cord injury (SCI) therapy. ...STATEMENT OF SIGNIFICANCE: Eff …
Precise fabrication of biomimetic three-dimensional (3D) structure and effective neuronal differentiation under the pathological envi …
A multi-channel collagen conduit with aligned Schwann cells and endothelial cells for enhanced neuronal regeneration in spinal cord injury.
Lee HY, Moon SH, Kang D, Choi E, Yang GH, Kim KN, Won JY, Yi S. Lee HY, et al. Biomater Sci. 2023 Dec 5;11(24):7884-7896. doi: 10.1039/d3bm01152f. Biomater Sci. 2023. PMID: 37906468
Traumatic spinal cord injury (SCI) leads to Wallerian degeneration and the accompanying disruption of vasculature leads to ischemia, which damages motor and sensory function. ...During axon elongation, SCs promote axon elongation while migrating along neovess …
Traumatic spinal cord injury (SCI) leads to Wallerian degeneration and the accompanying disruption of vasculature leads …
Engineering biomaterial microenvironments to promote myelination in the central nervous system.
Unal DB, Caliari SR, Lampe KJ. Unal DB, et al. Brain Res Bull. 2019 Oct;152:159-174. doi: 10.1016/j.brainresbull.2019.07.013. Epub 2019 Jul 12. Brain Res Bull. 2019. PMID: 31306690 Review.
Promoting remyelination and/or minimizing demyelination are key therapeutic strategies under investigation for diseases and injuries like multiple sclerosis (MS), spinal cord injury, stroke, and virus-induced encephalopathy. ...In particular, stiffness …
Promoting remyelination and/or minimizing demyelination are key therapeutic strategies under investigation for diseases and injuries
The Evolving Role of Induced Pluripotent Stem Cells and Cerebral Organoids in Treating and Modeling Neurosurgical Diseases.
Jovanovich N, Habib A, Kodavali C, Edwards L, Amankulor N, Zinn PO. Jovanovich N, et al. World Neurosurg. 2021 Nov;155:171-179. doi: 10.1016/j.wneu.2021.08.081. Epub 2021 Aug 25. World Neurosurg. 2021. PMID: 34454068 Review.
Transplantation of IPSCs is being studied in neurological injuries and diseases, such as spinal cord injury and Parkinson's disease, whose clinical manifestations stem from underlying neuronal and/or axonal degeneration. ...Such evidence makes IPSCs a …
Transplantation of IPSCs is being studied in neurological injuries and diseases, such as spinal cord injury and …
Application of biomimetic surfaces and 3D culture technology to study the role of extracellular matrix interactions in neurite outgrowth and inhibition.
Goncalves KE, Phillips S, Shah DSH, Athey D, Przyborski SA. Goncalves KE, et al. Biomater Adv. 2023 Jan;144:213204. doi: 10.1016/j.bioadv.2022.213204. Epub 2022 Nov 21. Biomater Adv. 2023. PMID: 36434926 Free article.
The microenvironment that cells experience during in vitro culture can often be far removed from the native environment they are exposed to in vivo. To recreate the physiological environment that developing neurites experience in vivo, we combine a well-estab …
The microenvironment that cells experience during in vitro culture can often be far removed from the native environment they a …
Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors.
Jones LL, Tuszynski MH. Jones LL, et al. J Neurosci. 2002 Jun 1;22(11):4611-24. doi: 10.1523/JNEUROSCI.22-11-04611.2002. J Neurosci. 2002. PMID: 12040068 Free PMC article.
Keratan sulfate proteoglycans (KSPGs) are extracellular matrix molecules that appear to establish boundaries for axonal growth in the developing brain and spinal cord. ...The aim of the current study was to investigate whether KSPGs are expresse …
Keratan sulfate proteoglycans (KSPGs) are extracellular matrix molecules that appear to establish boundaries for axonal growth
Effective Modulation of CNS Inhibitory Microenvironment using Bioinspired Hybrid-Nanoscaffold-Based Therapeutic Interventions.
Yang L, Conley BM, Cerqueira SR, Pongkulapa T, Wang S, Lee JK, Lee KB. Yang L, et al. Adv Mater. 2020 Oct;32(43):e2002578. doi: 10.1002/adma.202002578. Epub 2020 Sep 6. Adv Mater. 2020. PMID: 32893402 Free PMC article.
By tailoring the structural and biochemical properties of the 3D porous nanoscaffold, enhanced axonal growth from the dual-targeting therapeutic strategy in a human induced pluripotent stem cell (hiPSC)-based in vitro model of neuroinflammation …
By tailoring the structural and biochemical properties of the 3D porous nanoscaffold, enhanced axonal growth from the dual-tar …
Evaluation of biomaterials for bladder augmentation using cystometric analyses in various rodent models.
Tu DD, Seth A, Gil ES, Kaplan DL, Mauney JR, Estrada CR Jr. Tu DD, et al. J Vis Exp. 2012 Aug 9;(66):3981. doi: 10.3791/3981. J Vis Exp. 2012. PMID: 22907252 Free PMC article.
A number of congenital and acquired urological anomalies including posterior urethral valves, benign prostatic hyperplasia, and neurogenic bladder secondary to spina bifida/spinal cord injury can result in pathologic tissue remodeling leading to impaired comp …
A number of congenital and acquired urological anomalies including posterior urethral valves, benign prostatic hyperplasia, and neurogenic b …
11 results