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1992 1
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2002 1
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2010 2
2011 2
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2014 5
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Page 1
Developmental and epileptic encephalopathies: recognition and approaches to care.
Raga S, Specchio N, Rheims S, Wilmshurst JM. Raga S, et al. Epileptic Disord. 2021 Feb 1;23(1):40-52. doi: 10.1684/epd.2021.1244. Epileptic Disord. 2021. PMID: 33632673 Review.
The term "developmental and epileptic encephalopathy" (DEE) refers to when cognitive functions are influenced by both seizure and interictal epileptiform activity and the neurobiological process behind the epilepsy. ...In this setting, neurocognition, …
The term "developmental and epileptic encephalopathy" (DEE) refers to when cognitive functions are influenced by both s …
Cerebral plasticity: Windows of opportunity in the developing brain.
Ismail FY, Fatemi A, Johnston MV. Ismail FY, et al. Eur J Paediatr Neurol. 2017 Jan;21(1):23-48. doi: 10.1016/j.ejpn.2016.07.007. Epub 2016 Aug 9. Eur J Paediatr Neurol. 2017. PMID: 27567276 Review.
This malleability is achieved by modulating subsets of genetic, molecular and cellular mechanisms that influence the dynamics of synaptic connections and neural circuitry formation culminating in gain or loss of behavior or function. Neuroplasticity in the healthy developing b …
This malleability is achieved by modulating subsets of genetic, molecular and cellular mechanisms that influence the dynamics of synaptic co …
Current and future pharmacotherapy options for drug-resistant epilepsy.
Elkommos S, Mula M. Elkommos S, et al. Expert Opin Pharmacother. 2022 Dec;23(18):2023-2034. doi: 10.1080/14656566.2022.2128670. Epub 2022 Sep 27. Expert Opin Pharmacother. 2022. PMID: 36154780 Review.
INTRODUCTION: Epilepsy is a common neurological condition, affecting over 70 million individuals worldwide. ...For adult focal epilepsies, padsevonil and carisbamate are at a more advanced Phase III stage of clinical development followed by compounds at Phase II like selur …
INTRODUCTION: Epilepsy is a common neurological condition, affecting over 70 million individuals worldwide. ...For adult focal epilep …
The Phenotypic Continuum of ATP1A3-Related Disorders.
Vezyroglou A, Akilapa R, Barwick K, Koene S, Brownstein CA, Holder-Espinasse M, Fry AE, Németh AH, Tofaris GK, Hay E, Hughes I, Mansour S, Mordekar SR, Splitt M, Turnpenny PD, Demetriou D, Koopmann TT, Ruivenkamp CAL, Agrawal PB, Carr L, Clowes V, Ghali N, Holder SE, Radley J, Male A, Sisodiya SM, Kurian MA, Cross JH, Balasubramanian M. Vezyroglou A, et al. Neurology. 2022 Oct 4;99(14):e1511-e1526. doi: 10.1212/WNL.0000000000200927. Epub 2022 Jul 18. Neurology. 2022. PMID: 36192182 Free PMC article. Review.
METHODS: Undiagnosed individuals with ATP1A3 variants were identified within the cohort of the Deciphering Developmental Disorders study with additional cases contributed by collaborators internationally. ...
METHODS: Undiagnosed individuals with ATP1A3 variants were identified within the cohort of the Deciphering Developmental Disorders st …
Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children.
McTague A, Martland T, Appleton R. McTague A, et al. Cochrane Database Syst Rev. 2018 Jan 10;1(1):CD001905. doi: 10.1002/14651858.CD001905.pub3. Cochrane Database Syst Rev. 2018. PMID: 29320603 Free PMC article. Review.
SEARCH METHODS: For the latest update we searched the Cochrane Epilepsy Group's Specialised Register (23 May 2017), the Cochrane Central Register of Controlled Trials (CENTRAL) via the Cochrane Register of Studies Online (CRSO, 23 May 2017), MEDLINE (O …
SEARCH METHODS: For the latest update we searched the Cochrane Epilepsy Group's Specialised Register (23 May 2017), the …
Learnings in developmental and epileptic encephalopathies: what do we know?
Perinelli MG, Riva A, Amadori E, Follo R, Striano P. Perinelli MG, et al. Expert Rev Neurother. 2023 Jan;23(1):45-57. doi: 10.1080/14737175.2023.2176221. Epub 2023 Feb 8. Expert Rev Neurother. 2023. PMID: 36726225 Review.
INTRODUCTION: Developmental and Epileptic Encephalopathies (DEEs) encompass a group of neurological disorders caused by either abnormal neuronal development and white matter maturation or even by weak synaptic plasticity. Hitherto, patients commonly have e …
INTRODUCTION: Developmental and Epileptic Encephalopathies (DEEs) encompass a group of neurological disorders caused by …
Current and promising therapeutic options for Dravet syndrome.
Riva A, D'Onofrio G, Amadori E, Tripodi D, Balagura G, Iurilli V, Vari MS, Verrotti A, Striano P. Riva A, et al. Expert Opin Pharmacother. 2022 Oct;23(15):1727-1736. doi: 10.1080/14656566.2022.2127089. Epub 2022 Sep 21. Expert Opin Pharmacother. 2022. PMID: 36124778 Review.
INTRODUCTION: Dravet Syndrome (DS) is a developmental and epileptic encephalopathy carrying high-level psychobehavioral burdens. ...
INTRODUCTION: Dravet Syndrome (DS) is a developmental and epileptic encephalopathy carrying high-level psychobehavioral …
In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions.
Martin P, Czerwiński M, Limaye PB, Muranjan S, Ogilvie BW, Smith S, Boyd B. Martin P, et al. Pharmacol Res Perspect. 2022 Jun;10(3):e00958. doi: 10.1002/prp2.958. Pharmacol Res Perspect. 2022. PMID: 35599345 Free PMC article. Review.
Fenfluramine (FFA) has potent antiseizure activity in severe, pharmacoresistant childhood-onset developmental and epileptic encephalopathies (e.g., Dravet syndrome). ...Reaction phenotyping showed metabolism of FFA by recombinant human cytochrome P450 (rCYP) …
Fenfluramine (FFA) has potent antiseizure activity in severe, pharmacoresistant childhood-onset developmental and epileptic …
Brain-derived neurotrophic factor and epilepsy: a systematic review.
Iughetti L, Lucaccioni L, Fugetto F, Predieri B, Berardi A, Ferrari F. Iughetti L, et al. Neuropeptides. 2018 Dec;72:23-29. doi: 10.1016/j.npep.2018.09.005. Epub 2018 Sep 20. Neuropeptides. 2018. PMID: 30262417 Review.
Several in vitro, ex vivo and in vivo studies imply brain-derived neurotrophic factor (BDNF) in the pathophysiology of epilepsy. ...Medline, CENTRAL, and Science Direct were searched till August 2017 using keywords agreed by the authors. Together with a defined role …
Several in vitro, ex vivo and in vivo studies imply brain-derived neurotrophic factor (BDNF) in the pathophysiology of epilepsy …
Epigenetic mechanisms in epilepsy.
Kobow K, Blümcke I. Kobow K, et al. Prog Brain Res. 2014;213:279-316. doi: 10.1016/B978-0-444-63326-2.00014-4. Prog Brain Res. 2014. PMID: 25194494 Review.
In humans, genomic DNA is organized in 23 chromosome pairs coding for roughly 25,000 genes. Not all of them are active at all times. ...Thus, widespread reconfiguration of the epigenome is not only a key feature of neurodevelopment, brain maturation, and adult br …
In humans, genomic DNA is organized in 23 chromosome pairs coding for roughly 25,000 genes. Not all of them are active at all times. …
60 results