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Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides.
J Med Chem. 1992 Apr 3;35(7):1318-20. doi: 10.1021/jm00085a020.
J Med Chem. 1992.
PMID: 1560443
No abstract available.
Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase.
Goldstein DM, Soth M, Gabriel T, Dewdney N, Kuglstatter A, Arzeno H, Chen J, Bingenheimer W, Dalrymple SA, Dunn J, Farrell R, Frauchiger S, La Fargue J, Ghate M, Graves B, Hill RJ, Li F, Litman R, Loe B, McIntosh J, McWeeney D, Papp E, Park J, Reese HF, Roberts RT, Rotstein D, San Pablo B, Sarma K, Stahl M, Sung ML, Suttman RT, Sjogren EB, Tan Y, Trejo A, Welch M, Weller P, Wong BR, Zecic H.
Goldstein DM, et al.
J Med Chem. 2011 Apr 14;54(7):2255-65. doi: 10.1021/jm101423y. Epub 2011 Mar 4.
J Med Chem. 2011.
PMID: 21375264
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Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis.
Lou Y, Han X, Kuglstatter A, Kondru RK, Sweeney ZK, Soth M, McIntosh J, Litman R, Suh J, Kocer B, Davis D, Park J, Frauchiger S, Dewdney N, Zecic H, Taygerly JP, Sarma K, Hong J, Hill RJ, Gabriel T, Goldstein DM, Owens TD.
Lou Y, et al.
J Med Chem. 2015 Jan 8;58(1):512-6. doi: 10.1021/jm500305p. Epub 2014 Apr 16.
J Med Chem. 2015.
PMID: 24712864
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Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs.
Chen JJ, Dewdney N, Lin X, Martin RL, Walker KA, Huang J, Chu F, Eugui E, Mirkovich A, Kim Y, Sarma K, Arzeno H, Van Wart HE.
Chen JJ, et al.
Bioorg Med Chem Lett. 2003 Nov 17;13(22):3951-4. doi: 10.1016/j.bmcl.2003.08.076.
Bioorg Med Chem Lett. 2003.
PMID: 14592482
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Acyloin formation by benzoylformate decarboxylase from Pseudomonas putida.
Wilcocks R, Ward OP, Collins S, Dewdney NJ, Hong Y, Prosen E.
Wilcocks R, et al. Among authors: dewdney nj.
Appl Environ Microbiol. 1992 May;58(5):1699-704. doi: 10.1128/aem.58.5.1699-1704.1992.
Appl Environ Microbiol. 1992.
PMID: 1622241
Free PMC article.
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3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead.
Soth M, Abbot S, Abubakari A, Arora N, Arzeno H, Billedeau R, Dewdney N, Durkin K, Frauchiger S, Ghate M, Goldstein DM, Hill RJ, Kuglstatter A, Li F, Loe B, McCaleb K, McIntosh J, Papp E, Park J, Stahl M, Sung ML, Suttman R, Swinney DC, Weller P, Wong B, Zecic H, Gabriel T.
Soth M, et al.
Bioorg Med Chem Lett. 2011 Jun 1;21(11):3452-6. doi: 10.1016/j.bmcl.2011.03.098. Epub 2011 Apr 1.
Bioorg Med Chem Lett. 2011.
PMID: 21515047
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