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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
Sonveaux P, Végran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, De Saedeleer CJ, Kennedy KM, Diepart C, Jordan BF, Kelley MJ, Gallez B, Wahl ML, Feron O, Dewhirst MW. Sonveaux P, et al. Among authors: dewhirst mw. J Clin Invest. 2008 Dec;118(12):3930-42. doi: 10.1172/JCI36843. Epub 2008 Nov 20. J Clin Invest. 2008. PMID: 19033663 Free PMC article.
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
Sonveaux P, Copetti T, De Saedeleer CJ, Végran F, Verrax J, Kennedy KM, Moon EJ, Dhup S, Danhier P, Frérart F, Gallez B, Ribeiro A, Michiels C, Dewhirst MW, Feron O. Sonveaux P, et al. Among authors: dewhirst mw. PLoS One. 2012;7(3):e33418. doi: 10.1371/journal.pone.0033418. Epub 2012 Mar 13. PLoS One. 2012. PMID: 22428047 Free PMC article.
Common responses of tumors and wounds to hypoxia.
Payen VL, Brisson L, Dewhirst MW, Sonveaux P. Payen VL, et al. Among authors: dewhirst mw. Cancer J. 2015 Mar-Apr;21(2):75-87. doi: 10.1097/PPO.0000000000000098. Cancer J. 2015. PMID: 25815847 Review.
Regulation of HIF-1alpha stability through S-nitrosylation.
Li F, Sonveaux P, Rabbani ZN, Liu S, Yan B, Huang Q, Vujaskovic Z, Dewhirst MW, Li CY. Li F, et al. Among authors: dewhirst mw. Mol Cell. 2007 Apr 13;26(1):63-74. doi: 10.1016/j.molcel.2007.02.024. Mol Cell. 2007. PMID: 17434127 Free PMC article.
612 results