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Two dipolar α-helices within hormone-encoding regions of proglucagon are sorting signals to the regulated secretory pathway.
Guizzetti L, McGirr R, Dhanvantari S. Guizzetti L, et al. Among authors: dhanvantari s. J Biol Chem. 2014 May 23;289(21):14968-80. doi: 10.1074/jbc.M114.563684. Epub 2014 Apr 11. J Biol Chem. 2014. PMID: 24727476 Free PMC article.
Our previous work suggested that proglucagon is directed into granules by intrinsic sorting signals after initial processing to glicentin and major proglucagon fragment (McGirr, R., Guizzetti, L., and Dhanvantari, S. (2013) J. Endocrinol. 217, 229-240), leading to t …
Our previous work suggested that proglucagon is directed into granules by intrinsic sorting signals after initial processing to glicentin an …
[No authors listed] [No authors listed] PMID: 27917285
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