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A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex.
Patel A, Vought VE, Dharmarajan V, Cosgrove MS. Patel A, et al. Among authors: dharmarajan v. J Biol Chem. 2008 Nov 21;283(47):32162-75. doi: 10.1074/jbc.M806317200. Epub 2008 Oct 1. J Biol Chem. 2008. PMID: 18829457
Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.
Patel A, Dharmarajan V, Cosgrove MS. Patel A, et al. Among authors: dharmarajan v. J Biol Chem. 2008 Nov 21;283(47):32158-61. doi: 10.1074/jbc.C800164200. Epub 2008 Oct 1. J Biol Chem. 2008. PMID: 18829459
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
Patel A, Dharmarajan V, Vought VE, Cosgrove MS. Patel A, et al. Among authors: dharmarajan v. J Biol Chem. 2009 Sep 4;284(36):24242-56. doi: 10.1074/jbc.M109.014498. Epub 2009 Jun 25. J Biol Chem. 2009. PMID: 19556245 Free PMC article.
A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex.
Patel A, Vought VE, Dharmarajan V, Cosgrove MS. Patel A, et al. Among authors: dharmarajan v. J Biol Chem. 2011 Feb 4;286(5):3359-69. doi: 10.1074/jbc.M110.174524. Epub 2010 Nov 24. J Biol Chem. 2011. PMID: 21106533 Free PMC article.
Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
Dharmarajan V, Lee JH, Patel A, Skalnik DG, Cosgrove MS. Dharmarajan V, et al. J Biol Chem. 2012 Aug 10;287(33):27275-89. doi: 10.1074/jbc.M112.364125. Epub 2012 Jun 3. J Biol Chem. 2012. PMID: 22665483 Free PMC article.
Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
Patel A, Vought VE, Swatkoski S, Viggiano S, Howard B, Dharmarajan V, Monteith KE, Kupakuwana G, Namitz KE, Shinsky SA, Cotter RJ, Cosgrove MS. Patel A, et al. Among authors: dharmarajan v. J Biol Chem. 2014 Jan 10;289(2):868-84. doi: 10.1074/jbc.M113.501064. Epub 2013 Nov 14. J Biol Chem. 2014. PMID: 24235145 Free PMC article.
A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.
Shkriabai N, Dharmarajan V, Slaughter A, Kessl JJ, Larue RC, Feng L, Fuchs JR, Griffin PR, Kvaratskhelia M. Shkriabai N, et al. Among authors: dharmarajan v. J Biol Chem. 2014 Sep 19;289(38):26430-40. doi: 10.1074/jbc.M114.589572. Epub 2014 Aug 12. J Biol Chem. 2014. PMID: 25118283 Free PMC article.
A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions.
Peng Y, Zeng W, Ye H, Han KH, Dharmarajan V, Novick S, Wilson IA, Griffin PR, Friedman JM, Lerner RA. Peng Y, et al. Among authors: dharmarajan v. Chem Biol. 2015 Aug 20;22(8):1134-43. doi: 10.1016/j.chembiol.2015.07.011. Epub 2015 Aug 13. Chem Biol. 2015. PMID: 26278185
The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. Feng L, et al. Among authors: dharmarajan v. ACS Chem Biol. 2016 May 20;11(5):1313-21. doi: 10.1021/acschembio.6b00167. Epub 2016 Mar 2. ACS Chem Biol. 2016. PMID: 26910179 Free PMC article.
Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex.
Mays SG, Okafor CD, Tuntland ML, Whitby RJ, Dharmarajan V, Stec J, Griffin PR, Ortlund EA. Mays SG, et al. Among authors: dharmarajan v. Mol Pharmacol. 2017 Jul;92(1):1-11. doi: 10.1124/mol.117.108514. Epub 2017 Mar 31. Mol Pharmacol. 2017. PMID: 28363985 Free PMC article.
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