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Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.
Patel A, Dharmarajan V, Cosgrove MS. Patel A, et al. Among authors: dharmarajan v. J Biol Chem. 2008 Nov 21;283(47):32158-61. doi: 10.1074/jbc.C800164200. Epub 2008 Oct 1. J Biol Chem. 2008. PMID: 18829459
A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions.
Peng Y, Zeng W, Ye H, Han KH, Dharmarajan V, Novick S, Wilson IA, Griffin PR, Friedman JM, Lerner RA. Peng Y, et al. Among authors: dharmarajan v. Chem Biol. 2015 Aug 20;22(8):1134-43. doi: 10.1016/j.chembiol.2015.07.011. Epub 2015 Aug 13. Chem Biol. 2015. PMID: 26278185
Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
Patel A, Vought VE, Swatkoski S, Viggiano S, Howard B, Dharmarajan V, Monteith KE, Kupakuwana G, Namitz KE, Shinsky SA, Cotter RJ, Cosgrove MS. Patel A, et al. Among authors: dharmarajan v. J Biol Chem. 2014 Jan 10;289(2):868-84. doi: 10.1074/jbc.M113.501064. Epub 2013 Nov 14. J Biol Chem. 2014. PMID: 24235145 Free PMC article.
Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
Dharmarajan V, Lee JH, Patel A, Skalnik DG, Cosgrove MS. Dharmarajan V, et al. J Biol Chem. 2012 Aug 10;287(33):27275-89. doi: 10.1074/jbc.M112.364125. Epub 2012 Jun 3. J Biol Chem. 2012. PMID: 22665483 Free PMC article.
A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex.
Patel A, Vought VE, Dharmarajan V, Cosgrove MS. Patel A, et al. Among authors: dharmarajan v. J Biol Chem. 2011 Feb 4;286(5):3359-69. doi: 10.1074/jbc.M110.174524. Epub 2010 Nov 24. J Biol Chem. 2011. PMID: 21106533 Free PMC article.
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
Patel A, Dharmarajan V, Vought VE, Cosgrove MS. Patel A, et al. Among authors: dharmarajan v. J Biol Chem. 2009 Sep 4;284(36):24242-56. doi: 10.1074/jbc.M109.014498. Epub 2009 Jun 25. J Biol Chem. 2009. PMID: 19556245 Free PMC article.
A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex.
Patel A, Vought VE, Dharmarajan V, Cosgrove MS. Patel A, et al. Among authors: dharmarajan v. J Biol Chem. 2008 Nov 21;283(47):32162-75. doi: 10.1074/jbc.M806317200. Epub 2008 Oct 1. J Biol Chem. 2008. PMID: 18829457
Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation.
Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR. Lewallen DM, et al. Among authors: dharmarajan v. ACS Chem Biol. 2014 Feb 21;9(2):433-42. doi: 10.1021/cb4006886. Epub 2013 Nov 25. ACS Chem Biol. 2014. PMID: 24274060 Free PMC article.
HDX-MS guided drug discovery: small molecules and biopharmaceuticals.
Marciano DP, Dharmarajan V, Griffin PR. Marciano DP, et al. Among authors: dharmarajan v. Curr Opin Struct Biol. 2014 Oct;28:105-11. doi: 10.1016/j.sbi.2014.08.007. Epub 2014 Aug 30. Curr Opin Struct Biol. 2014. PMID: 25179005 Free PMC article. Review.
Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, Griffin PR, Katzenellenbogen JA, Nettles KW. Srinivasan S, et al. Among authors: dharmarajan v. Nat Chem Biol. 2017 Jan;13(1):111-118. doi: 10.1038/nchembio.2236. Epub 2016 Nov 21. Nat Chem Biol. 2017. PMID: 27870835 Free PMC article.
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