Dhekne HS - Search Results

1

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M. Steger M, et al. Among authors: dhekne hs. Elife. 2017 Nov 10;6:e31012. doi: 10.7554/eLife.31012. Elife. 2017. PMID: 29125462 Free PMC article.

2

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR. Purlyte E, et al. Among authors: dhekne hs. EMBO J. 2018 Jan 4;37(1):1-18. doi: 10.15252/embj.201798099. Epub 2017 Dec 6. EMBO J. 2018. PMID: 29212815 Free PMC article.

3

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.

Dhekne HS, Yanatori I, Gomez RC, Tonelli F, Diez F, Schüle B, Steger M, Alessi DR, Pfeffer SR. Dhekne HS, et al. Elife. 2018 Nov 6;7:e40202. doi: 10.7554/eLife.40202. Elife. 2018. PMID: 30398148 Free PMC article.

4

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR. Purlyte E, et al. Among authors: dhekne hs. EMBO J. 2019 Jan 15;38(2):e101237. doi: 10.15252/embj.2018101237. EMBO J. 2019. PMID: 30647193 Free PMC article.

5

Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.

Sobu Y, Wawro PS, Dhekne HS, Yeshaw WM, Pfeffer SR. Sobu Y, et al. Among authors: dhekne hs. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2005894118. doi: 10.1073/pnas.2005894118. Proc Natl Acad Sci U S A. 2021. PMID: 33653948 Free PMC article.

6

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.

Dhekne HS, Yanatori I, Vides EG, Sobu Y, Diez F, Tonelli F, Pfeffer SR. Dhekne HS, et al. Life Sci Alliance. 2021 Mar 16;4(5):e202101050. doi: 10.26508/lsa.202101050. Print 2021 May. Life Sci Alliance. 2021. PMID: 33727250 Free PMC article.

7

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain.

Khan SS, Sobu Y, Dhekne HS, Tonelli F, Berndsen K, Alessi DR, Pfeffer SR. Khan SS, et al. Among authors: dhekne hs. Elife. 2021 Oct 18;10:e67900. doi: 10.7554/eLife.67900. Elife. 2021. PMID: 34658337 Free PMC article.

8

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation.

Vides EG, Adhikari A, Chiang CY, Lis P, Purlyte E, Limouse C, Shumate JL, Spínola-Lasso E, Dhekne HS, Alessi DR, Pfeffer SR. Vides EG, et al. Among authors: dhekne hs. Elife. 2022 Sep 23;11:e79771. doi: 10.7554/eLife.79771. Elife. 2022. PMID: 36149401 Free PMC article.

9

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.

Dhekne HS, Tonelli F, Yeshaw WM, Chiang CY, Limouse C, Jaimon E, Purlyte E, Alessi DR, Pfeffer SR. Dhekne HS, et al. Elife. 2023 Oct 24;12:e87098. doi: 10.7554/eLife.87098. Elife. 2023. PMID: 37874635 Free PMC article.

10

Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.

Yeshaw WM, Adhikari A, Chiang CY, Dhekne HS, Wawro PS, Pfeffer SR. Yeshaw WM, et al. Among authors: dhekne hs. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2315171120. doi: 10.1073/pnas.2315171120. Epub 2023 Oct 27. Proc Natl Acad Sci U S A. 2023. PMID: 37889931 Free PMC article.

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