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MAP kinase signalling pathways in cancer.
Dhillon AS, Hagan S, Rath O, Kolch W. Dhillon AS, et al. Oncogene. 2007 May 14;26(22):3279-90. doi: 10.1038/sj.onc.1210421. Oncogene. 2007. PMID: 17496922 Review.
Cancer can be perceived as a disease of communication between and within cells. The aberrations are pleiotropic, but mitogen-activated protein kinase (MAPK) pathways feature prominently. ...Stress-activated pathways, such as Jun N-terminal kinase and p38, largely se …
Cancer can be perceived as a disease of communication between and within cells. The aberrations are pleiotropic, but mitogen-activate …
Phosphatase and feedback regulation of Raf-1 signaling.
Dhillon AS, von Kriegsheim A, Grindlay J, Kolch W. Dhillon AS, et al. Cell Cycle. 2007 Jan 1;6(1):3-7. doi: 10.4161/cc.6.1.3593. Epub 2007 Jan 9. Cell Cycle. 2007. PMID: 17218791 Review.
Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5.
von Kriegsheim A, Pitt A, Grindlay GJ, Kolch W, Dhillon AS. von Kriegsheim A, et al. Nat Cell Biol. 2006 Sep;8(9):1011-6. doi: 10.1038/ncb1465. Epub 2006 Aug 6. Nat Cell Biol. 2006. PMID: 16892053
The Raf-MEK-ERK pathway couples growth factor, mitogenic and extracellular matrix signals to cell fate decisions such as growth, proliferation, migration, differentiation and survival. ...Protein phosphatase 5 (PP5) was identified as an inactivator that associates w …
The Raf-MEK-ERK pathway couples growth factor, mitogenic and extracellular matrix signals to cell fate decisions such as growth, prol …
Oncogenic B-Raf mutations: crystal clear at last.
Dhillon AS, Kolch W. Dhillon AS, et al. Cancer Cell. 2004 Apr;5(4):303-4. doi: 10.1016/s1535-6108(04)00087-x. Cancer Cell. 2004. PMID: 15093535
Dystroglycan, a scaffold for the ERK-MAP kinase cascade.
Spence HJ, Dhillon AS, James M, Winder SJ. Spence HJ, et al. EMBO Rep. 2004 May;5(5):484-9. doi: 10.1038/sj.embor.7400140. Epub 2004 Apr 8. EMBO Rep. 2004. PMID: 15071496 Free PMC article.
These studies suggest a role for dystroglycan as a multifunctional adaptor or scaffold capable of interacting with components of the ERK-MAP kinase cascade including MEK and ERK. These findings have important implications for our understanding of the role of dystroglycan i …
These studies suggest a role for dystroglycan as a multifunctional adaptor or scaffold capable of interacting with components of the …
A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.
Dhillon AS, Meikle S, Peyssonnaux C, Grindlay J, Kaiser C, Steen H, Shaw PE, Mischak H, Eychène A, Kolch W. Dhillon AS, et al. Mol Cell Biol. 2003 Mar;23(6):1983-93. doi: 10.1128/mcb.23.6.1983-1993.2003. Mol Cell Biol. 2003. PMID: 12612072 Free PMC article.
In NIH 3T3 fibroblasts and COS-1 cells, mutation of serine 259 resulted in Raf-1 proteins which activated the MEK/ERK pathway as efficiently as v-Raf. ...
In NIH 3T3 fibroblasts and COS-1 cells, mutation of serine 259 resulted in Raf-1 proteins which activated the MEK/ERK pathway as effi …
Untying the regulation of the Raf-1 kinase.
Dhillon AS, Kolch W. Dhillon AS, et al. Arch Biochem Biophys. 2002 Aug 1;404(1):3-9. doi: 10.1016/s0003-9861(02)00244-8. Arch Biochem Biophys. 2002. PMID: 12127063 Review.
As such, Raf-1 is regulated by complex mechanisms that are incompletely understood. Recent results have shown that release from repression is an important event that facilitates the interaction of Raf-1 with the Ras activator and its substrate, MAPK/ERK-1/2 kinase. ...The
As such, Raf-1 is regulated by complex mechanisms that are incompletely understood. Recent results have shown that release from repre
Regulation of Raf-1 activation and signalling by dephosphorylation.
Dhillon AS, Meikle S, Yazici Z, Eulitz M, Kolch W. Dhillon AS, et al. EMBO J. 2002 Jan 15;21(1-2):64-71. doi: 10.1093/emboj/21.1.64. EMBO J. 2002. PMID: 11782426 Free PMC article.
The Raf-1 kinase is regulated by phosphorylation, and Ser259 has been identified as an inhibitory phosphorylation site. Here we show that the dephosphorylation of Ser259 is an essential part of the Raf-1 activation process, and further reveal the molecular role of Ser259. …
The Raf-1 kinase is regulated by phosphorylation, and Ser259 has been identified as an inhibitory phosphorylation site. Here we show …
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.
Dhillon AS, Pollock C, Steen H, Shaw PE, Mischak H, Kolch W. Dhillon AS, et al. Mol Cell Biol. 2002 May;22(10):3237-46. doi: 10.1128/mcb.22.10.3237-3246.2002. Mol Cell Biol. 2002. PMID: 11971957 Free PMC article.
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