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Withania somnifera: an Indian ginseng.
Kulkarni SK, Dhir A. Kulkarni SK, et al. Among authors: dhir a. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1093-105. doi: 10.1016/j.pnpbp.2007.09.011. Epub 2007 Sep 21. Prog Neuropsychopharmacol Biol Psychiatry. 2008. PMID: 17959291 Review.
In Ayurveda, it is classified as a rasayana (rejuvenation) and expected to promote physical and mental health, rejuvenate the body in debilitated conditions and increase longevity. ...
In Ayurveda, it is classified as a rasayana (rejuvenation) and expected to promote physical and mental health, rejuvenate the body in …
New therapeutic promises in the treatment of depression and schizophrenia.
Dhir A, Kulkarni SK. Dhir A, et al. Drug News Perspect. 2008 Dec;21(10):581-92. Drug News Perspect. 2008. PMID: 19221639
Cyclooxygenase in epilepsy: from perception to application.
Kulkarni SK, Dhir A. Kulkarni SK, et al. Among authors: dhir a. Drugs Today (Barc). 2009 Feb;45(2):135-54. doi: 10.1358/dot.2009.45.2.1322481. Drugs Today (Barc). 2009. PMID: 19343233 Review.
Cyclooxygenase (COX) catalyzes the first committed step in the synthesis of prostanoids, a large family of arachidonic acid metabolites comprising prostaglandins, prostacyclin and thromboxanes. ...It is speculated that COX inhibition will be a useful ameliorative ad …
Cyclooxygenase (COX) catalyzes the first committed step in the synthesis of prostanoids, a large family of arachidonic acid metabolit …
Animal models of tardive dyskinesia.
Kulkarni SK, Dhir A. Kulkarni SK, et al. Among authors: dhir a. Int Rev Neurobiol. 2011;98:265-87. doi: 10.1016/B978-0-12-381328-2.00011-0. Int Rev Neurobiol. 2011. PMID: 21907091 Review.
Tardive dyskinesia (TD) is a complex hyperkinetic syndrome characterized by choriform, athetoid, and rhythmic abnormal involuntary movements. ...
Tardive dyskinesia (TD) is a complex hyperkinetic syndrome characterized by choriform, athetoid, and rhythmic abnormal involuntary mo …
Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders.
Kulkarni SK, Dhir A. Kulkarni SK, et al. Among authors: dhir a. Phytother Res. 2010 Mar;24(3):317-24. doi: 10.1002/ptr.2968. Phytother Res. 2010. PMID: 19998323 Review.
However, more detailed clinical trials along with a safety assessment of berberine are warranted for positioning the alkaloid in the treatment of neurological disorders....
However, more detailed clinical trials along with a safety assessment of berberine are warranted for positioning the alkaloid in the …
sigma-1 receptors in major depression and anxiety.
Kulkarni SK, Dhir A. Kulkarni SK, et al. Among authors: dhir a. Expert Rev Neurother. 2009 Jul;9(7):1021-34. doi: 10.1586/ern.09.40. Expert Rev Neurother. 2009. PMID: 19589051 Review.
A large number of drugs that alter these neurotransmitter levels/systems are effective in the treatment of major depression and anxiety. ...Recently, the role of sigma-receptors, particularly the sigma-1 receptor subtype, has been identified as a target for the path
A large number of drugs that alter these neurotransmitter levels/systems are effective in the treatment of major depression and anxie
Current investigational drugs for major depression.
Kulkarni SK, Dhir A. Kulkarni SK, et al. Among authors: dhir a. Expert Opin Investig Drugs. 2009 Jun;18(6):767-88. doi: 10.1517/13543780902880850. Expert Opin Investig Drugs. 2009. PMID: 19426122 Review.
BACKGROUND: The World Health Organization (WHO) report has predicted that major depression will become a key cause of illness-induced disability by the year 2020, second only to ischemic heart diseases. OBJECTIVES/METHODS: Although a large number of antidepressant d …
BACKGROUND: The World Health Organization (WHO) report has predicted that major depression will become a key cause of illness-induced …
Risperidone, an atypical antipsychotic enhances the antidepressant-like effect of venlafaxine or fluoxetine: possible involvement of alpha-2 adrenergic receptors.
Dhir A, Kulkarni SK. Dhir A, et al. Neurosci Lett. 2008 Nov 7;445(1):83-8. doi: 10.1016/j.neulet.2008.08.074. Epub 2008 Aug 31. Neurosci Lett. 2008. PMID: 18778754
Immobility period was recorded for a period of 6 min. Venlafaxine (4 and 8 mg/kg, i.p.) or fluoxetine (10 and 20 mg/kg, i.p.) inhibited the immobility period in mice. ...
Immobility period was recorded for a period of 6 min. Venlafaxine (4 and 8 mg/kg, i.p.) or fluoxetine (10 and 20 mg/kg, i.p.) inhibit …
Effect of Withania somnifera Dunal root extract against pentylenetetrazol seizure threshold in mice: possible involvement of GABAergic system.
Kulkarni SK, Akula KK, Dhir A. Kulkarni SK, et al. Among authors: dhir a. Indian J Exp Biol. 2008 Jun;46(6):465-9. Indian J Exp Biol. 2008. PMID: 18697606
Withania somnifera (ashwagandha) is a widely used herb in the Ayurvedic system of medicine. The objective of the present study was to elucidate the effect of W. somnifera root extract (Ws) alone or in combination with exogenous gamma-amino butyric acid (GABA), a GAB …
Withania somnifera (ashwagandha) is a widely used herb in the Ayurvedic system of medicine. The objective of the present study was to …
Tiagabine, a GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats.
Dhir A, Akula KK, Kulkarni SK. Dhir A, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):835-43. doi: 10.1016/j.pnpbp.2007.12.017. Epub 2008 Jan 29. Prog Neuropsychopharmacol Biol Psychiatry. 2008. PMID: 18234412
Further in the later stage of life, the degeneration extends to a variety of brain regions, including the hypothalamus and hippocampus. ...Further, there was a decrease in adrenal ascorbic acid levels following daily administration of 3-nitropropionic acid, which wa …
Further in the later stage of life, the degeneration extends to a variety of brain regions, including the hypothalamus and hippocampu …
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