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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 1
2004 1
2005 2
2006 2
2007 2
2008 1
2010 2
2011 5
2012 2
2013 4
2014 3
2015 2
2016 2
2017 2
2018 2
2019 5
2020 6
2021 5
2022 6
2023 7
2024 7
2025 7
2026 1

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72 results

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Page 1
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction.
Simanshu DK, Xu R, Stice JP, Czyzyk DJ, Feng S, Denson JP, Riegler E, Yang Y, Zhang C, Donovan S, Smith BP, Abreu-Blanco M, Chen M, Feng C, Fu L, Rabara D, Young LC, Dyba M, Yan W, Lin K, Ghorbanpoorvalukolaie S, Larsen EK, Malik W, Champagne A, Parker K, Ju JH, Jeknic S, Esposito D, Turner DM, Lightstone FC, Wang B, Wehn PM, Wang K, Stephen AG, Maciag AE, Hata AN, Sinkevicius KW, Nissley DV, Wallace EM, McCormick F, Beltran PJ. Simanshu DK, et al. Science. 2025 Jul 24;389(6758):409-415. doi: 10.1126/science.adq2004. Epub 2025 Jun 12. Science. 2025. PMID: 40504949
Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin.
Terayama K, Furuzono S, Fer N, Yan W, Young LC, Czyzyk DJ, Goldstein de Salazar R, Sasaki M, Uozumi A, Konishi M, Kanda S, Sogawa Y, Yamaguchi M, Tsuji T, Kuroyanagi J, Hayashi M, Ogura Y, Simanshu DK, Kubota K, Tanaka J, McCormick F. Terayama K, et al. Among authors: simanshu dk. Science. 2025 Jul 24;389(6758):402-408. doi: 10.1126/science.adr9097. Epub 2025 Jul 24. Science. 2025. PMID: 40705882
Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.
Maciag AE, Stice JP, Wang B, Sharma AK, Chan AH, Lin K, Singh D, Dyba M, Yang Y, Setoodeh S, Smith BP, Ju JH, Jeknic S, Rabara D, Zhang Z, Larsen EK, Esposito D, Denson JP, Ranieri M, Meynardie M, Mehdizadeh S, Alexander PA, Abreu Blanco M, Turner DM, Xu R, Lightstone FC, Wong KK, Stephen AG, Wang K, Simanshu DK, Sinkevicius KW, Nissley DV, Wallace E, McCormick F, Beltran PJ. Maciag AE, et al. Among authors: simanshu dk. Cancer Discov. 2025 Mar 3;15(3):578-594. doi: 10.1158/2159-8290.CD-24-0840. Cancer Discov. 2025. PMID: 39642212 Free PMC article.
Structural basis for LZTR1 recognition of RAS GTPases for degradation.
Dharmaiah S, Bonsor DA, Mo SP, Fernandez-Cabrera A, Chan AH, Messing S, Drew M, Vega M, Nissley DV, Esposito D, Castel P, Simanshu DK. Dharmaiah S, et al. Among authors: simanshu dk. Science. 2025 Sep 11;389(6765):1112-1117. doi: 10.1126/science.adv7088. Epub 2025 Sep 11. Science. 2025. PMID: 40934300 Free PMC article.
Functional and structural insights into RAS effector proteins.
Mozzarelli AM, Simanshu DK, Castel P. Mozzarelli AM, et al. Among authors: simanshu dk. Mol Cell. 2024 Aug 8;84(15):2807-2821. doi: 10.1016/j.molcel.2024.06.027. Epub 2024 Jul 17. Mol Cell. 2024. PMID: 39025071 Free PMC article. Review.
Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
Kwon JJ, Dilly J, Liu S, Kim E, Bian Y, Dharmaiah S, Tran TH, Kapner KS, Ly SH, Yang X, Rabara D, Waybright TJ, Giacomelli AO, Hong AL, Misek S, Wang B, Ravi A, Doench JG, Beroukhim R, Lemke CT, Haigis KM, Esposito D, Root DE, Nissley DV, Stephen AG, McCormick F, Simanshu DK, Hahn WC, Aguirre AJ. Kwon JJ, et al. Among authors: simanshu dk. bioRxiv [Preprint]. 2024 Oct 25:2024.10.22.618529. doi: 10.1101/2024.10.22.618529. bioRxiv. 2024. PMID: 39484452 Free PMC article. Preprint.
RIT1 oncoproteins escape LZTR1-mediated proteolysis.
Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F. Castel P, et al. Among authors: simanshu dk. Science. 2019 Mar 15;363(6432):1226-1230. doi: 10.1126/science.aav1444. Science. 2019. PMID: 30872527 Free PMC article.
72 results