Inhibiting repressive epigenetic modification promotes telomere rejuvenation in somatic cell reprogramming.
Yang L, Liu X, Song L, Su G, Di A, Bai C, Wei Z, Li G.
Yang L, et al. Among authors: di a.
FASEB J. 2019 Dec;33(12):13982-13997. doi: 10.1096/fj.201901486RR. Epub 2019 Oct 23.
FASEB J. 2019.
PMID: 31645134
The efficiency of somatic cell nuclear transfer (SCNT) reprogramming is extremely low in terms of production of cloned animals. Here, we found that telomere rejuvenation is a critical event for SCNT reprogramming. Through small-molecule screening, we identified that melato …
The efficiency of somatic cell nuclear transfer (SCNT) reprogramming is extremely low in terms of production of cloned animals. Here, we fou …