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TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Hall-Roberts H, Agarwal D, Obst J, Smith TB, Monzón-Sandoval J, Di Daniel E, Webber C, James WS, Mead E, Davis JB, Cowley SA. Hall-Roberts H, et al. Among authors: di daniel e. Alzheimers Res Ther. 2020 Nov 16;12(1):151. doi: 10.1186/s13195-020-00709-z. Alzheimers Res Ther. 2020. PMID: 33198789 Free PMC article.
Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain.
Szykowska A, Chen Y, Smith TB, Preger C, Yang J, Qian D, Mukhopadhyay SM, Wigren E, Neame SJ, Gräslund S, Persson H, Atkinson PJ, Di Daniel E, Mead E, Wang J, Davis JB, Burgess-Brown NA, Bullock AN. Szykowska A, et al. Among authors: di daniel e. Structure. 2021 Nov 4;29(11):1241-1252.e5. doi: 10.1016/j.str.2021.06.010. Epub 2021 Jul 6. Structure. 2021. PMID: 34233201 Free PMC article.
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