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Inhibition of the NLRP3 inflammasome by HSP90 inhibitors.
Nizami S, Arunasalam K, Green J, Cook J, Lawrence CB, Zarganes-Tzitzikas T, Davis JB, Di Daniel E, Brough D. Nizami S, et al. Among authors: di daniel e. Immunology. 2021 Jan;162(1):84-91. doi: 10.1111/imm.13267. Epub 2020 Oct 30. Immunology. 2021. PMID: 32954500 Free PMC article.
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Hall-Roberts H, Agarwal D, Obst J, Smith TB, Monzón-Sandoval J, Di Daniel E, Webber C, James WS, Mead E, Davis JB, Cowley SA. Hall-Roberts H, et al. Among authors: di daniel e. Alzheimers Res Ther. 2020 Nov 16;12(1):151. doi: 10.1186/s13195-020-00709-z. Alzheimers Res Ther. 2020. PMID: 33198789 Free PMC article.
Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain.
Szykowska A, Chen Y, Smith TB, Preger C, Yang J, Qian D, Mukhopadhyay SM, Wigren E, Neame SJ, Gräslund S, Persson H, Atkinson PJ, Di Daniel E, Mead E, Wang J, Davis JB, Burgess-Brown NA, Bullock AN. Szykowska A, et al. Among authors: di daniel e. Structure. 2021 Jun 25:S0969-2126(21)00214-8. doi: 10.1016/j.str.2021.06.010. Online ahead of print. Structure. 2021. PMID: 34233201 Free article.
TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.
Fischer FA, Mies LFM, Nizami S, Pantazi E, Danielli S, Demarco B, Ohlmeyer M, Lee MSJ, Coban C, Kagan JC, Di Daniel E, Bezbradica JS. Fischer FA, et al. Among authors: di daniel e. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2009309118. doi: 10.1073/pnas.2009309118. Proc Natl Acad Sci U S A. 2021. PMID: 34518217 Free article.
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