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Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome.
Cremon C, Stanghellini V, Barbaro MR, Cogliandro RF, Bellacosa L, Santos J, Vicario M, Pigrau M, Alonso Cotoner C, Lobo B, Azpiroz F, Bruley des Varannes S, Neunlist M, DeFilippis D, Iuvone T, Petrosino S, Di Marzo V, Barbara G. Cremon C, et al. Among authors: Di Marzo V. Aliment Pharmacol Ther. 2017 Apr;45(7):909-922. doi: 10.1111/apt.13958. Epub 2017 Feb 6. Aliment Pharmacol Ther. 2017. PMID: 28164346 Clinical Trial.
Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis.
Petrosino S, Puigdemont A, Della Valle MF, Fusco M, Verde R, AllarĂ  M, Aveta T, Orlando P, Di Marzo V. Petrosino S, et al. Among authors: Di Marzo V. Vet J. 2016 Jan;207:85-91. doi: 10.1016/j.tvjl.2015.10.060. Epub 2015 Nov 10. Vet J. 2016. PMID: 26639824
Diacerein is a potent and selective inhibitor of palmitoylethanolamide inactivation with analgesic activity in a rat model of acute inflammatory pain.
Petrosino S, Ahmad A, Marcolongo G, Esposito E, AllarĂ  M, Verde R, Cuzzocrea S, Di Marzo V. Petrosino S, et al. Among authors: Di Marzo V. Pharmacol Res. 2015 Jan;91:9-14. doi: 10.1016/j.phrs.2014.10.008. Epub 2014 Nov 1. Pharmacol Res. 2015. PMID: 25447594
Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study.
Valastro C, Campanile D, Marinaro M, Franchini D, Piscitelli F, Verde R, Di Marzo V, Di Bello A. Valastro C, et al. Among authors: Di Marzo V, Di Bello A. BMC Vet Res. 2017 Nov 6;13(1):309. doi: 10.1186/s12917-017-1245-7. BMC Vet Res. 2017. PMID: 29110674 Free PMC article.
Protective effect of palmitoylethanolamide in a rat model of cystitis.
Pessina F, Capasso R, Borrelli F, Aveta T, Buono L, Valacchi G, Fiorenzani P, Di Marzo V, Orlando P, Izzo AA. Pessina F, et al. Among authors: Di Marzo V. J Urol. 2015 Apr;193(4):1401-8. doi: 10.1016/j.juro.2014.11.083. Epub 2014 Nov 18. J Urol. 2015. PMID: 25463999
Anti-inflammatory effect of palmitoylethanolamide on human adipocytes.
Hoareau L, Buyse M, Festy F, Ravanan P, Gonthier MP, Matias I, Petrosino S, Tallet F, d'Hellencourt CL, Cesari M, Di Marzo V, Roche R. Hoareau L, et al. Among authors: Di Marzo V. Obesity (Silver Spring). 2009 Mar;17(3):431-8. doi: 10.1038/oby.2008.591. Epub 2009 Jan 8. Obesity (Silver Spring). 2009. PMID: 19131941
The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels.
Petrosino S, Schiano Moriello A, Cerrato S, Fusco M, Puigdemont A, De Petrocellis L, Di Marzo V. Petrosino S, et al. Among authors: Di Marzo V. Br J Pharmacol. 2016 Apr;173(7):1154-62. doi: 10.1111/bph.13084. Epub 2015 Mar 26. Br J Pharmacol. 2016. PMID: 25598150 Free PMC article.
Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis.
Abramo F, Campora L, Albanese F, della Valle MF, Cristino L, Petrosino S, Di Marzo V, Miragliotta V. Abramo F, et al. Among authors: Di Marzo V. BMC Vet Res. 2014 Jan 14;10:21. doi: 10.1186/1746-6148-10-21. BMC Vet Res. 2014. PMID: 24423192 Free PMC article.
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