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Enhanced survival and regeneration of axotomized retinal neurons by repeated delivery of cell-permeable C3-like Rho antagonists.
Bertrand J, Di Polo A, McKerracher L. Bertrand J, et al. Among authors: di polo a. Neurobiol Dis. 2007 Jan;25(1):65-72. doi: 10.1016/j.nbd.2006.08.008. Epub 2006 Sep 28. Neurobiol Dis. 2007. PMID: 17011202
Inactivation of Rho GTPase with a single intraocular injection of Rho antagonists stimulates survival and regeneration of retinal ganglion cells (RGCs) after optic nerve injury. ...
Inactivation of Rho GTPase with a single intraocular injection of Rho antagonists stimulates survival and regeneration of retinal gan …
Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells.
Di Polo A, Aigner LJ, Dunn RJ, Bray GM, Aguayo AJ. Di Polo A, et al. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3978-83. doi: 10.1073/pnas.95.7.3978. Proc Natl Acad Sci U S A. 1998. PMID: 9520478 Free PMC article.
In this study, we demonstrate that: (i) injection of an adenovirus (Ad) vector containing the brain-derived neurotrophic factor (BDNF) gene (Ad.BDNF) into the vitreous chamber of adult rats results in selective transgene expression by Müller cells; (ii) in vitro, Müller cells inf …
In this study, we demonstrate that: (i) injection of an adenovirus (Ad) vector containing the brain-derived neurotrophic factor (BDNF) gene …
TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo.
Cheng L, Sapieha P, Kittlerova P, Hauswirth WW, Di Polo A. Cheng L, et al. Among authors: di polo a. J Neurosci. 2002 May 15;22(10):3977-86. doi: 10.1523/JNEUROSCI.22-10-03977.2002. J Neurosci. 2002. PMID: 12019317 Free PMC article.
We tested this hypothesis in a model of CNS injury: retinal ganglion cell (RGC) death after transection of the adult rat optic nerve. ...TrkB gene transfer into RGCs combined with exogenous BDNF administration markedly increased neuronal survival: 76% of RGCs remained aliv …
We tested this hypothesis in a model of CNS injury: retinal ganglion cell (RGC) death after transection of the adult rat optic nerve. …
Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury.
Sapieha PS, Peltier M, Rendahl KG, Manning WC, Di Polo A. Sapieha PS, et al. Among authors: di polo a. Mol Cell Neurosci. 2003 Nov;24(3):656-72. doi: 10.1016/s1044-7431(03)00228-8. Mol Cell Neurosci. 2003. PMID: 14664816
Basic fibroblast growth factor (or FGF-2) has been shown to be a potent stimulator of retinal ganglion cell (RGC) axonal growth during development. ...FGF-2 gene transfer led to a 10-fold increase in the number of axons that extended past 0.5 mm from the lesion site …
Basic fibroblast growth factor (or FGF-2) has been shown to be a potent stimulator of retinal ganglion cell (RGC) axonal growth durin …
Extracellular signal-regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo.
Pernet V, Hauswirth WW, Di Polo A. Pernet V, et al. Among authors: di polo a. J Neurochem. 2005 Apr;93(1):72-83. doi: 10.1111/j.1471-4159.2005.03002.x. J Neurochem. 2005. PMID: 15773907
The goal of this study was to define the role of the extracellular signal-regulated kinases 1/2 (Erk1/2) pathway in the survival and axon regeneration of adult rat retinal ganglion cells (RGCs), a prototypical central neuron population. ...We conclude that the Erk1/2 pathw …
The goal of this study was to define the role of the extracellular signal-regulated kinases 1/2 (Erk1/2) pathway in the survival and axon re …
Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS.
Sapieha PS, Duplan L, Uetani N, Joly S, Tremblay ML, Kennedy TE, Di Polo A. Sapieha PS, et al. Among authors: di polo a. Mol Cell Neurosci. 2005 Apr;28(4):625-35. doi: 10.1016/j.mcn.2004.10.011. Mol Cell Neurosci. 2005. PMID: 15797710
Quantitative analysis demonstrated a significant increase in the number of RGC axons that crossed the glial scar and extended distally in optic nerves from RPTPsigma (-/-) mice compared to wild-type littermate controls. ...Our results support a model in which RPTPsi …
Quantitative analysis demonstrated a significant increase in the number of RGC axons that crossed the glial scar and extended distall …
Activation of the extracellular signal-regulated kinase 1/2 pathway by AAV gene transfer protects retinal ganglion cells in glaucoma.
Zhou Y, Pernet V, Hauswirth WW, Di Polo A. Zhou Y, et al. Among authors: di polo a. Mol Ther. 2005 Sep;12(3):402-12. doi: 10.1016/j.ymthe.2005.04.004. Mol Ther. 2005. PMID: 15975850
Ocular hypertension is a major risk factor in glaucoma, but visual field defects continue to progress in some patients despite the use of drugs that lower intraocular pressure. ...We conclude that the Erk1/2 pathway plays a key role in the protection of RGCs from oc …
Ocular hypertension is a major risk factor in glaucoma, but visual field defects continue to progress in some patients despite the us …
Brain-derived neurotrophic factor gene delivery to muller glia preserves structure and function of light-damaged photoreceptors.
Gauthier R, Joly S, Pernet V, Lachapelle P, Di Polo A. Gauthier R, et al. Among authors: di polo a. Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3383-92. doi: 10.1167/iovs.05-0362. Invest Ophthalmol Vis Sci. 2005. PMID: 16123443
For example, after 10 days of exposure to light, the average percentage of ONL preservation in the superior central retina of eyes that received Ad.BDNF was 71%, compared with 46% in eyes that received a control Ad.GFP or 15% in contralateral eyes. Of importance, retinas e …
For example, after 10 days of exposure to light, the average percentage of ONL preservation in the superior central retina of eyes that rece …
Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo.
Pernet V, Di Polo A. Pernet V, et al. Among authors: di polo a. Brain. 2006 Apr;129(Pt 4):1014-26. doi: 10.1093/brain/awl015. Epub 2006 Jan 17. Brain. 2006. PMID: 16418178
Our results demonstrate that BDNF and lens injury interact synergistically to promote neuronal survival: 71% of RGCs were alive at 2 weeks after optic nerve injury, a time when only approximately 10% of these neurons remain without treatment. ...The effect of BDNF could no …
Our results demonstrate that BDNF and lens injury interact synergistically to promote neuronal survival: 71% of RGCs were alive at 2 weeks a …
Extracellular signal-regulated kinases 1/2 are required for adult retinal ganglion cell axon regeneration induced by fibroblast growth factor-2.
Sapieha PS, Hauswirth WW, Di Polo A. Sapieha PS, et al. Among authors: di polo a. J Neurosci Res. 2006 May 1;83(6):985-95. doi: 10.1002/jnr.20803. J Neurosci Res. 2006. PMID: 16493686
For this purpose, a novel adeno-associated virus (AAV) was used to deliver the FGF-2 gene to RGCs, providing a sustained source of this neurotrophic factor. ...
For this purpose, a novel adeno-associated virus (AAV) was used to deliver the FGF-2 gene to RGCs, providing a sustained sourc …
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