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The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries.
Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, Verdun di Cantogno L, Dallaglio K, Castellano I, Amici A, Centonze G, Sharma N, Lunardi S, Cabodi S, Cavallo F, Lamolinara A, Stramucci L, Moiso E, Provero P, Albini A, Sapino A, Staaf J, Di Fiore PP, Bertalot G, Pece S, Tosoni D, Confalonieri S, Iezzi M, Di Stefano P, Turco E, Defilippi P. Grasso S, et al. Among authors: di stefano p, di fiore pp. Nat Commun. 2017 Mar 16;8:14797. doi: 10.1038/ncomms14797. Nat Commun. 2017. PMID: 28300085 Free PMC article.
Mapping of p140Cap phosphorylation sites: the EPLYA and EGLYA motifs have a key role in tyrosine phosphorylation and Csk binding, and are substrates of the Abl kinase.
Repetto D, Aramu S, Boeri Erba E, Sharma N, Grasso S, Russo I, Jensen ON, Cabodi S, Turco E, Di Stefano P, Defilippi P. Repetto D, et al. Among authors: di stefano p. PLoS One. 2013;8(1):e54931. doi: 10.1371/journal.pone.0054931. Epub 2013 Jan 31. PLoS One. 2013. PMID: 23383002 Free PMC article.
Integrins and signal transduction.
Cabodi S, Di Stefano P, Leal Mdel P, Tinnirello A, Bisaro B, Morello V, Damiano L, Aramu S, Repetto D, Tornillo G, Defilippi P. Cabodi S, et al. Among authors: di stefano p. Adv Exp Med Biol. 2010;674:43-54. doi: 10.1007/978-1-4419-6066-5_5. Adv Exp Med Biol. 2010. PMID: 20549939 Review.
p130Cas: a versatile scaffold in signaling networks.
Defilippi P, Di Stefano P, Cabodi S. Defilippi P, et al. Among authors: di stefano p. Trends Cell Biol. 2006 May;16(5):257-63. doi: 10.1016/j.tcb.2006.03.003. Epub 2006 Apr 3. Trends Cell Biol. 2006. PMID: 16581250 Review.
p130Cas is an essential transducer element in ErbB2 transformation.
Cabodi S, Tinnirello A, Bisaro B, Tornillo G, del Pilar Camacho-Leal M, Forni G, Cojoca R, Iezzi M, Amici A, Montani M, Eva A, Di Stefano P, Muthuswamy SK, Tarone G, Turco E, Defilippi P. Cabodi S, et al. Among authors: di stefano p. FASEB J. 2010 Oct;24(10):3796-808. doi: 10.1096/fj.10-157347. Epub 2010 May 26. FASEB J. 2010. PMID: 20505116
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