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Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis.
Kim DJ, Angel JM, Sano S, DiGiovanni J. Kim DJ, et al. Oncogene. 2009 Feb 19;28(7):950-60. doi: 10.1038/onc.2008.453. Epub 2009 Jan 12. Oncogene. 2009. PMID: 19137019 Free PMC article.
Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis.
Chan KS, Sano S, Kataoka K, Abel E, Carbajal S, Beltran L, Clifford J, Peavey M, Shen J, Digiovanni J. Chan KS, et al. Oncogene. 2008 Feb 14;27(8):1087-94. doi: 10.1038/sj.onc.1210726. Epub 2007 Aug 13. Oncogene. 2008. PMID: 17700521
Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development.
Kiguchi K, Bol D, Carbajal S, Beltrán L, Moats S, Chan K, Jorcano J, DiGiovanni J. Kiguchi K, et al. Oncogene. 2000 Aug 31;19(37):4243-54. doi: 10.1038/sj.onc.1203778. Oncogene. 2000. PMID: 10980598
Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion.
DiGiovanni J, Bol DK, Wilker E, Beltrán L, Carbajal S, Moats S, Ramirez A, Jorcano J, Kiguchi K. DiGiovanni J, et al. Cancer Res. 2000 Mar 15;60(6):1561-70. Cancer Res. 2000. PMID: 10749124
Alteration of Egr-1 mRNA during multistage carcinogenesis in mouse skin.
Riggs PK, Rho O, DiGiovanni J. Riggs PK, et al. Mol Carcinog. 2000 Apr;27(4):247-51. doi: 10.1002/(sici)1098-2744(200004)27:4<247::aid-mc1>;2-4. Mol Carcinog. 2000. PMID: 10747287
Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice.
DiGiovanni J, Kiguchi K, Frijhoff A, Wilker E, Bol DK, Beltrán L, Moats S, Ramirez A, Jorcano J, Conti C. DiGiovanni J, et al. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3455-60. doi: 10.1073/pnas.97.7.3455. Proc Natl Acad Sci U S A. 2000. PMID: 10737798 Free PMC article.
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