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Pharmacodynamics, pharmacokinetics, safety and tolerability of the novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 agonist RG7697 after single subcutaneous administration in healthy subjects.
Portron A, Jadidi S, Sarkar N, DiMarchi R, Schmitt C. Portron A, et al. Among authors: dimarchi r. Diabetes Obes Metab. 2017 Oct;19(10):1446-1453. doi: 10.1111/dom.13025. Epub 2017 Jul 25. Diabetes Obes Metab. 2017. PMID: 28741871 Clinical Trial.
Pharmacodynamics, pharmacokinetics and safety of multiple ascending doses of the novel dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 agonist RG7697 in people with type 2 diabetes mellitus.
Schmitt C, Portron A, Jadidi S, Sarkar N, DiMarchi R. Schmitt C, et al. Among authors: dimarchi r. Diabetes Obes Metab. 2017 Oct;19(10):1436-1445. doi: 10.1111/dom.13024. Epub 2017 Jul 20. Diabetes Obes Metab. 2017. PMID: 28730694 Clinical Trial.
Insulin structure and function.
Mayer JP, Zhang F, DiMarchi RD. Mayer JP, et al. Biopolymers. 2007;88(5):687-713. doi: 10.1002/bip.20734. Biopolymers. 2007. PMID: 17410596 Review.
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH. Finan B, et al. Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8. Nat Med. 2015. PMID: 25485909
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