Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1988 1
2003 2
2006 1
2007 1
2008 1
2009 1
2010 1
2011 3
2012 2
2013 4
2014 5
2015 4
2016 3
2017 4
2018 6
2019 12
2020 6
2021 8
2022 5
2023 6
2024 12
2025 17
2026 12

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

101 results

Results by year

Filters applied: . Clear all
Page 1
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial.
Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Stefanetti R, Trenell M, Welsh P, Kean S, Ford I, McConnachie A, Sattar N, Taylor R. Lean ME, et al. Lancet. 2018 Feb 10;391(10120):541-551. doi: 10.1016/S0140-6736(17)33102-1. Epub 2017 Dec 5. Lancet. 2018. PMID: 29221645 Free article. Clinical Trial.
BACKGROUND: Type 2 diabetes is a chronic disorder that requires lifelong treatment. We aimed to assess whether intensive weight management within routine primary care would achieve remission of type 2 diabetes. ...INTERPRETATION: Our findings show that, at 12 …
BACKGROUND: Type 2 diabetes is a chronic disorder that requires lifelong treatment. We aimed to assess whether intensive weight manag …
Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial.
Lean MEJ, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Welsh P, Kean S, Ford I, McConnachie A, Messow CM, Sattar N, Taylor R. Lean MEJ, et al. Lancet Diabetes Endocrinol. 2019 May;7(5):344-355. doi: 10.1016/S2213-8587(19)30068-3. Epub 2019 Mar 6. Lancet Diabetes Endocrinol. 2019. PMID: 30852132 Free article. Clinical Trial.
BACKGROUND: The DiRECT trial assessed remission of type 2 diabetes during a primary care-led weight-management programme. ...Sustained remission was linked to the extent of sustained weight loss. FUNDING: Diabetes UK....
BACKGROUND: The DiRECT trial assessed remission of type 2 diabetes during a primary care-led weight-management p …
5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study.
Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Kelly T, Irvine K, Peters C, Zhyzhneuskaya S, Hollingsworth KG, Adamson AJ, Sniehotta FF, Mathers JC, McIlvenna Y, Welsh P, McConnachie A, McIntosh A, Sattar N, Taylor R. Lean ME, et al. Lancet Diabetes Endocrinol. 2024 Apr;12(4):233-246. doi: 10.1016/S2213-8587(23)00385-6. Epub 2024 Feb 26. Lancet Diabetes Endocrinol. 2024. PMID: 38423026 Free article. Clinical Trial.
BACKGROUND: In DiRECT, a randomised controlled effectiveness trial, weight management intervention after 2 years resulted in mean weight loss of 7.6 kg, with 36% of participants in remission of type 2 diabetes. ...At 5 years, DiRECT extension pa …
BACKGROUND: In DiRECT, a randomised controlled effectiveness trial, weight management intervention after 2 years resulted in m …
Definition and diagnostic criteria of clinical obesity.
Rubino F, Cummings DE, Eckel RH, Cohen RV, Wilding JPH, Brown WA, Stanford FC, Batterham RL, Farooqi IS, Farpour-Lambert NJ, le Roux CW, Sattar N, Baur LA, Morrison KM, Misra A, Kadowaki T, Tham KW, Sumithran P, Garvey WT, Kirwan JP, Fernández-Real JM, Corkey BE, Toplak H, Kokkinos A, Kushner RF, Branca F, Valabhji J, Blüher M, Bornstein SR, Grill HJ, Ravussin E, Gregg E, Al Busaidi NB, Alfaris NF, Al Ozairi E, Carlsson LMS, Clément K, Després JP, Dixon JB, Galea G, Kaplan LM, Laferrère B, Laville M, Lim S, Luna Fuentes JR, Mooney VM, Nadglowski J Jr, Urudinachi A, Olszanecka-Glinianowicz M, Pan A, Pattou F, Schauer PR, Tschöp MH, van der Merwe MT, Vettor R, Mingrone G. Rubino F, et al. Lancet Diabetes Endocrinol. 2025 Mar;13(3):221-262. doi: 10.1016/S2213-8587(24)00316-4. Epub 2025 Jan 14. Lancet Diabetes Endocrinol. 2025. PMID: 39824205 Free PMC article. Review.
We define preclinical obesity as a state of excess adiposity with preserved function of other tissues and organs and a varying, but generally increased, risk of developing clinical obesity and several other non-communicable diseases (eg, type 2 diabetes, cardiovascu …
We define preclinical obesity as a state of excess adiposity with preserved function of other tissues and organs and a varying, but generall …
Delivering the Diabetes Remission Clinical Trial (DiRECT) in primary care: Experiences of healthcare professionals.
Rehackova L, Taylor R, Lean M, Barnes A, McCombie L, Thom G, Brosnahan N, Leslie WS, Sniehotta FF. Rehackova L, et al. Diabet Med. 2022 Mar;39(3):e14752. doi: 10.1111/dme.14752. Epub 2021 Dec 15. Diabet Med. 2022. PMID: 34837259 Free article.
OBJECTIVE: The Diabetes Remission Clinical Trial (DiRECT) used a formula total diet replacement programme followed by structured weight loss maintenance to induce and sustain weight loss and remission of type 2 diabetes (T2D) in 36 …
OBJECTIVE: The Diabetes Remission Clinical Trial (DiRECT) used a formula total diet replacement programme …
Participant experiences in the Diabetes REmission Clinical Trial (DiRECT).
Rehackova L, Rodrigues AM, Thom G, Brosnahan N, Barnes AC, McCombie L, Leslie WS, Zhyzhneuskaya S, Peters C, Adamson AJ, Lean MEJ, Taylor R, Sniehotta FF. Rehackova L, et al. Diabet Med. 2022 Jan;39(1):e14689. doi: 10.1111/dme.14689. Epub 2021 Sep 18. Diabet Med. 2022. PMID: 34519099 Free article. Clinical Trial.
INTRODUCTION: The Diabetes REmission Clinical Trial (DiRECT) has shown that sustained remission of type 2 diabetes in primary care is achievable through weight loss using total diet replacement (TDR) with continued behavioural supp …
INTRODUCTION: The Diabetes REmission Clinical Trial (DiRECT) has shown that sustained remission of …
Understanding the mechanisms of reversal of type 2 diabetes.
Taylor R, Al-Mrabeh A, Sattar N. Taylor R, et al. Lancet Diabetes Endocrinol. 2019 Sep;7(9):726-736. doi: 10.1016/S2213-8587(19)30076-2. Epub 2019 May 13. Lancet Diabetes Endocrinol. 2019. PMID: 31097391 Review.
Clinical and pathophysiological studies have shown type 2 diabetes to be a condition mainly caused by excess, yet reversible, fat accumulation in the liver and pancreas. ...Collectively, these changes can normalise blood glucose levels. Importantly, the primary care …
Clinical and pathophysiological studies have shown type 2 diabetes to be a condition mainly caused by excess, yet reversible, …
Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT).
Cassidy S, Trenell M, Stefanetti RJ, Charman SJ, Barnes AC, Brosnahan N, McCombie L, Thom G, Peters C, Zhyzhneuskaya S, Leslie WS, Catt C, Catt M, McConnachie A, Sattar N, Sniehotta FF, Lean MEJ, Taylor R. Cassidy S, et al. Diabet Med. 2023 Mar;40(3):e15010. doi: 10.1111/dme.15010. Epub 2022 Nov 29. Diabet Med. 2023. PMID: 36398460 Free PMC article. Clinical Trial.
AIMS: As sustained weight loss is vital for achieving remission of type 2 diabetes, we explored whether randomisation to weight loss plus maintenance in the DiRECT trial was associated with physical activity, inactivity or sleep. ...Physical activity w …
AIMS: As sustained weight loss is vital for achieving remission of type 2 diabetes, we explored whether randomisation to weigh …
Predictors of type 2 diabetes remission in the Diabetes Remission Clinical Trial (DiRECT).
Thom G, Messow CM, Leslie WS, Barnes AC, Brosnahan N, McCombie L, Al-Mrabeh A, Zhyzhneuskaya S, Welsh P, Sattar N, Taylor R, Lean MEJ. Thom G, et al. Diabet Med. 2021 Aug;38(8):e14395. doi: 10.1111/dme.14395. Epub 2020 Sep 27. Diabet Med. 2021. PMID: 32870520 Free article. Clinical Trial.
AIM: To identify predictors of type 2 diabetes remission in the intervention arm of DiRECT (Diabetes Remission Clinical Trial). ...Early weight loss and higher programme attendance predicted more remissions. Baseline BMI, fa …
AIM: To identify predictors of type 2 diabetes remission in the intervention arm of DiRECT (Diabetes Remissio …
The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT).
Corbin LJ, Hughes DA, Bull CJ, Vincent EE, Smith ML, McConnachie A, Messow CM, Welsh P, Taylor R, Lean MEJ, Sattar N, Timpson NJ. Corbin LJ, et al. Diabetologia. 2024 Jan;67(1):74-87. doi: 10.1007/s00125-023-06019-x. Epub 2023 Oct 25. Diabetologia. 2024. PMID: 37878066 Free PMC article.
We aimed to characterise the metabolomic consequences of a weight-loss intervention in individuals with type 2 diabetes. METHODS: We analysed 574 fasted serum samples collected within an existing RCT (the Diabetes Remission Clinical Trial [Di …
We aimed to characterise the metabolomic consequences of a weight-loss intervention in individuals with type 2 diabetes. METHODS: We …
101 results