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JAK2, the JAK2 V617F mutant and cytokine receptors.
Staerk J, Kallin A, Royer Y, Diaconu CC, Dusa A, Demoulin JB, Vainchenker W, Constantinescu SN. Staerk J, et al. Among authors: diaconu cc. Pathol Biol (Paris). 2007 Mar;55(2):88-91. doi: 10.1016/j.patbio.2006.06.003. Epub 2006 Aug 14. Pathol Biol (Paris). 2007. PMID: 16904848 Review.
Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.
Pecquet C, Diaconu CC, Staerk J, Girardot M, Marty C, Royer Y, Defour JP, Dusa A, Besancenot R, Giraudier S, Villeval JL, Knoops L, Courtoy PJ, Vainchenker W, Constantinescu SN. Pecquet C, et al. Among authors: diaconu cc. Blood. 2012 May 17;119(20):4625-35. doi: 10.1182/blood-2011-08-372524. Epub 2012 Feb 29. Blood. 2012. PMID: 22378845 Free article.
Cooccurring JAK2 V617F and R1063H mutations increase JAK2 signaling and neutrophilia in myeloproliferative neoplasms.
Mambet C, Babosova O, Defour JP, Leroy E, Necula L, Stanca O, Tatic A, Berbec N, Coriu D, Belickova M, Kralova B, Lanikova L, Vesela J, Pecquet C, Saussoy P, Havelange V, Diaconu CC, Divoky V, Constantinescu SN. Mambet C, et al. Among authors: diaconu cc. Blood. 2018 Dec 20;132(25):2695-2699. doi: 10.1182/blood-2018-04-843060. Epub 2018 Oct 30. Blood. 2018. PMID: 30377194 Free article. No abstract available.
Targets in MPNs and potential therapeutics.
Levy G, Mambet C, Pecquet C, Bailly S, Havelange V, Diaconu CC, Constantinescu SN. Levy G, et al. Among authors: diaconu cc. Int Rev Cell Mol Biol. 2022;366:41-81. doi: 10.1016/bs.ircmb.2021.06.004. Epub 2021 Sep 23. Int Rev Cell Mol Biol. 2022. PMID: 35153006
A Phenotypic Screen for Small-Molecule Inhibitors of Constitutively Active Mutant Thrombopoietin Receptor Implicated in Myeloproliferative Neoplasms.
Ngo A, Koay AZ, Pecquet C, Diaconu CC, Ould-Amer Y, Huang Q, Kang C, Poulsen A, Lee MA, Jenkins D, Shiau A, Constantinescu SN, Choong ML. Ngo A, et al. Among authors: diaconu cc. Comb Chem High Throughput Screen. 2016;19(10):824-833. doi: 10.2174/1386207319666161010163825. Comb Chem High Throughput Screen. 2016. PMID: 27748177
325 results