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Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy.
Diaz-Montero CM, Salem ML, Nishimura MI, Garrett-Mayer E, Cole DJ, Montero AJ. Diaz-Montero CM, et al. Cancer Immunol Immunother. 2009 Jan;58(1):49-59. doi: 10.1007/s00262-008-0523-4. Epub 2008 Apr 30. Cancer Immunol Immunother. 2009. PMID: 18446337 Free PMC article.
Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer.
Montero AJ, Díaz-Montero CM, Mao L, Youssef EM, Estecio M, Shen L, Issa JP. Montero AJ, et al. Cancer Biol Ther. 2006 Nov;5(11):1494-501. doi: 10.4161/cbt.5.11.3299. Epub 2006 Nov 19. Cancer Biol Ther. 2006. PMID: 17369752
Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model.
Díaz-Montero CM, El Naggar S, Al Khami A, El Naggar R, Montero AJ, Cole DJ, Salem ML. Díaz-Montero CM, et al. Cancer Immunol Immunother. 2008 Apr;57(4):563-72. doi: 10.1007/s00262-007-0394-0. Epub 2007 Aug 28. Cancer Immunol Immunother. 2008. PMID: 17726606 Free PMC article.
Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C).
Salem ML, Díaz-Montero CM, Al-Khami AA, El-Naggar SA, Naga O, Montero AJ, Khafagy A, Cole DJ. Salem ML, et al. J Immunol. 2009 Feb 15;182(4):2030-40. doi: 10.4049/jimmunol.0801829. J Immunol. 2009. PMID: 19201856 Free PMC article.
Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells.
Salem ML, Al-Khami AA, El-Naggar SA, Díaz-Montero CM, Chen Y, Cole DJ. Salem ML, et al. J Immunol. 2010 Feb 15;184(4):1737-47. doi: 10.4049/jimmunol.0902309. Epub 2010 Jan 18. J Immunol. 2010. PMID: 20083664 Free PMC article.
Phase 2 study of neoadjuvant treatment with NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II-IIIc breast cancer.
Montero AJ, Diaz-Montero CM, Deutsch YE, Hurley J, Koniaris LG, Rumboldt T, Yasir S, Jorda M, Garret-Mayer E, Avisar E, Slingerland J, Silva O, Welsh C, Schuhwerk K, Seo P, Pegram MD, Glück S. Montero AJ, et al. Breast Cancer Res Treat. 2012 Feb;132(1):215-23. doi: 10.1007/s10549-011-1889-0. Epub 2011 Dec 3. Breast Cancer Res Treat. 2012. PMID: 22138748 Free PMC article. Clinical Trial.
Myeloid-derived suppressor cells in cancer patients: a clinical perspective.
Montero AJ, Diaz-Montero CM, Kyriakopoulos CE, Bronte V, Mandruzzato S. Montero AJ, et al. J Immunother. 2012 Feb-Mar;35(2):107-15. doi: 10.1097/CJI.0b013e318242169f. J Immunother. 2012. PMID: 22306898 Review.
A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice.
Mehrotra S, Al-Khami AA, Klarquist J, Husain S, Naga O, Eby JM, Murali AK, Lyons GE, Li M, Spivey ND, Norell H, Martins da Palma T, Onicescu G, Diaz-Montero CM, Garrett-Mayer E, Cole DJ, Le Poole IC, Nishimura MI. Mehrotra S, et al. J Immunol. 2012 Aug 15;189(4):1627-38. doi: 10.4049/jimmunol.1103271. Epub 2012 Jul 13. J Immunol. 2012. PMID: 22798675 Free PMC article.
MEK inhibition abrogates sunitinib resistance in a renal cell carcinoma patient-derived xenograft model.
Diaz-Montero CM, Mao FJ, Barnard J, Parker Y, Zamanian-Daryoush M, Pink JJ, Finke JH, Rini BI, Lindner DJ. Diaz-Montero CM, et al. Br J Cancer. 2016 Oct 11;115(8):920-928. doi: 10.1038/bjc.2016.263. Epub 2016 Aug 25. Br J Cancer. 2016. PMID: 27560553 Free PMC article.
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