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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1980 2
1981 2
1982 1
1983 1
1984 2
1985 1
1986 3
1987 1
1989 2
1990 3
1991 6
1992 2
1993 4
1994 1
1995 7
1996 6
1997 7
1998 6
1999 4
2000 10
2001 4
2002 4
2003 3
2004 6
2005 3
2006 3
2007 10
2008 12
2009 11
2010 22
2011 24
2012 28
2013 37
2014 40
2015 56
2016 44
2017 28
2018 36
2019 43
2020 28
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460 results
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Page 1
Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications.
Tataranni T, Piccoli C. Tataranni T, et al. Oxid Med Cell Longev. 2019 Nov 14;2019:8201079. doi: 10.1155/2019/8201079. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31827705 Free PMC article. Review.
An extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administration in cancer therapy is still limited to clinical trials. ...Interestingly, DCA could significantly affect cancer stem cell fraction …
An extensive body of literature describes anticancer property of dichloroacetate (DCA), but its effective clinical administration in …
Dichloroacetate Affects Mitochondrial Function and Stemness-Associated Properties in Pancreatic Cancer Cell Lines.
Tataranni T, Agriesti F, Pacelli C, Ruggieri V, Laurenzana I, Mazzoccoli C, Sala GD, Panebianco C, Pazienza V, Capitanio N, Piccoli C. Tataranni T, et al. Cells. 2019 May 18;8(5):478. doi: 10.3390/cells8050478. Cells. 2019. PMID: 31109089 Free PMC article.
Targeting metabolism represents a possible successful approach to treat cancer. Dichloroacetate (DCA) is a drug known to divert metabolism from anaerobic glycolysis to mitochondrial oxidative phosphorylation by stimulation of PDH. ...In a xenograft pancreatic can
Targeting metabolism represents a possible successful approach to treat cancer. Dichloroacetate (DCA) is a drug known to diver …
Dichloroacetate and Salinomycin Exert a Synergistic Cytotoxic Effect in Colorectal Cancer Cell Lines.
Skeberdytė A, Sarapinienė I, Aleksander-Krasko J, Stankevičius V, Sužiedėlis K, Jarmalaitė S. Skeberdytė A, et al. Sci Rep. 2018 Dec 10;8(1):17744. doi: 10.1038/s41598-018-35815-4. Sci Rep. 2018. PMID: 30531808 Free PMC article.
In the present study, we examined a hypothesis that dichloroacetate, a metabolic inhibitor, might efficiently potentiate the cytotoxic effect of salinomycin, an antibiotic ionophore, on two human colorectal cancer derived cell lines DLD-1 and HCT116. ...Our findings …
In the present study, we examined a hypothesis that dichloroacetate, a metabolic inhibitor, might efficiently potentiate the cytotoxi …
Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy.
Abdel-Wahab AF, Mahmoud W, Al-Harizy RM. Abdel-Wahab AF, et al. Pharmacol Res. 2019 Dec;150:104511. doi: 10.1016/j.phrs.2019.104511. Epub 2019 Oct 31. Pharmacol Res. 2019. PMID: 31678210 Review.
Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which is a hallmark of cancer. ...These metabolic antiglycolytic agents could be more effective if …
Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely on aerobic glycolysis for energy production, a phe …
Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway.
Liang Y, Zhu D, Zhu L, Hou Y, Hou L, Huang X, Li L, Wang Y, Li L, Zou H, Wu T, Yao M, Wang J, Meng X. Liang Y, et al. J Cancer. 2019 Oct 15;10(24):6037-6047. doi: 10.7150/jca.34650. eCollection 2019. J Cancer. 2019. PMID: 31762813 Free PMC article.
Chemoresistance is responsible for most colorectal cancer (CRC) related deaths. In this study, we found that dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, can be used as a sensitizer for oxaliplatin (L-OHP) chemoresistant CRC cells. ...
Chemoresistance is responsible for most colorectal cancer (CRC) related deaths. In this study, we found that dichloroacetate ( …
Dichloroacetate and cancer: new home for an orphan drug?
Kankotia S, Stacpoole PW. Kankotia S, et al. Biochim Biophys Acta. 2014 Dec;1846(2):617-29. doi: 10.1016/j.bbcan.2014.08.005. Epub 2014 Aug 23. Biochim Biophys Acta. 2014. PMID: 25157892 Review.
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and congenital disorders of mitochondrial intermediary metabolism. Inhibition by DCA of mitochondrial pyruvate dehydrogenase kinases and subsequent rea …
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and congeni …
Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway.
Liang Y, Hou L, Li L, Li L, Zhu L, Wang Y, Huang X, Hou Y, Zhu D, Zou H, Gu Y, Weng X, Wang Y, Li Y, Wu T, Yao M, Gross I, Gaiddon C, Luo M, Wang J, Meng X. Liang Y, et al. Oncogene. 2020 Jan;39(2):469-485. doi: 10.1038/s41388-019-1035-8. Epub 2019 Oct 9. Oncogene. 2020. PMID: 31597953 Free PMC article.
The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as a metabolic regulator in the treatment of metabolic diseases; here, DCA was assayed to identify the mechani …
The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate
The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance.
Woolbright BL, Choudhary D, Mikhalyuk A, Trammel C, Shanmugam S, Abbott E, Pilbeam CC, Taylor JA 3rd. Woolbright BL, et al. Mol Cancer Ther. 2018 Sep;17(9):2004-2012. doi: 10.1158/1535-7163.MCT-18-0063. Epub 2018 Jun 15. Mol Cancer Ther. 2018. PMID: 29907593 Free PMC article.
We have previously observed upregulation of PDK4 in high-grade compared with low-grade bladder cancers. We initiated this study to determine if inhibition of PDK4 could reduce tumor growth rates or sensitize bladder cancer cells to cisplatin. ...Inhibition of PDK4 w …
We have previously observed upregulation of PDK4 in high-grade compared with low-grade bladder cancers. We initiated this study to de …
Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis.
El Sayed SM, Baghdadi H, Ahmed NS, Almaramhy HH, Mahmoud AA, El-Sawy SA, Ayat M, Elshazley M, Abdel-Aziz W, Abdel-Latif HM, Ibrahim W, Aboonq MS. El Sayed SM, et al. Med Hypotheses. 2019 Jan;122:206-209. doi: 10.1016/j.mehy.2018.11.012. Epub 2018 Nov 22. Med Hypotheses. 2019. PMID: 30593413
Dichloroacetate (DCA) is a promising safe anticancer drug that cured a patient with chemoresistant non-Hodgkin's lymphoma and treated lactic acidosis effectively. ...Acetate is important for cancer cells metabolism and survival as elevated acetate can drive r
Dichloroacetate (DCA) is a promising safe anticancer drug that cured a patient with chemoresistant non-Hodgkin's lymphoma and
Metabolic modulation of glioblastoma with dichloroacetate.
Michelakis ED, Sutendra G, Dromparis P, Webster L, Haromy A, Niven E, Maguire C, Gammer TL, Mackey JR, Fulton D, Abdulkarim B, McMurtry MS, Petruk KC. Michelakis ED, et al. Sci Transl Med. 2010 May 12;2(31):31ra34. doi: 10.1126/scitranslmed.3000677. Sci Transl Med. 2010. PMID: 20463368 Free article.
Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis. ...We tested whether the small-molecule and orphan …
Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as a r …
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