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A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5.
J Virol. 2010 Oct;84(20):10863-76. doi: 10.1128/JVI.01109-10. Epub 2010 Aug 11.
J Virol. 2010.
PMID: 20702642
Free PMC article.
Novel approaches to inhibit HIV entry.
Didigu CA, Doms RW.
Didigu CA, et al.
Viruses. 2012 Feb;4(2):309-24. doi: 10.3390/v4020309. Epub 2012 Feb 21.
Viruses. 2012.
PMID: 22470838
Free PMC article.
Review.
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The major cellular sterol regulatory pathway is required for Andes virus infection.
Petersen J, Drake MJ, Bruce EA, Riblett AM, Didigu CA, Wilen CB, Malani N, Male F, Lee FH, Bushman FD, Cherry S, Doms RW, Bates P, Briley K Jr.
Petersen J, et al. Among authors: didigu ca.
PLoS Pathog. 2014 Feb 6;10(2):e1003911. doi: 10.1371/journal.ppat.1003911. eCollection 2014 Feb.
PLoS Pathog. 2014.
PMID: 24516383
Free PMC article.
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Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.
Didigu CA, Wilen CB, Wang J, Duong J, Secreto AJ, Danet-Desnoyers GA, Riley JL, Gregory PD, June CH, Holmes MC, Doms RW.
Didigu CA, et al.
Blood. 2014 Jan 2;123(1):61-9. doi: 10.1182/blood-2013-08-521229. Epub 2013 Oct 25.
Blood. 2014.
PMID: 24162716
Free PMC article.
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IL-31 is produced by the malignant T-cell population in cutaneous T-Cell lymphoma and correlates with CTCL pruritus.
Singer EM, Shin DB, Nattkemper LA, Benoit BM, Klein RS, Didigu CA, Loren AW, Dentchev T, Wysocka M, Yosipovitch G, Rook AH.
Singer EM, et al. Among authors: didigu ca.
J Invest Dermatol. 2013 Dec;133(12):2783-2785. doi: 10.1038/jid.2013.227. Epub 2013 May 22.
J Invest Dermatol. 2013.
PMID: 23698099
Free article.
No abstract available.
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Quantitative phosphoproteomics reveals extensive cellular reprogramming during HIV-1 entry.
Wojcechowskyj JA, Didigu CA, Lee JY, Parrish NF, Sinha R, Hahn BH, Bushman FD, Jensen ST, Seeholzer SH, Doms RW.
Wojcechowskyj JA, et al. Among authors: didigu ca.
Cell Host Microbe. 2013 May 15;13(5):613-623. doi: 10.1016/j.chom.2013.04.011.
Cell Host Microbe. 2013.
PMID: 23684312
Free PMC article.
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Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.
Parker ZF, Iyer SS, Wilen CB, Parrish NF, Chikere KC, Lee FH, Didigu CA, Berro R, Klasse PJ, Lee B, Moore JP, Shaw GM, Hahn BH, Doms RW.
Parker ZF, et al. Among authors: didigu ca.
J Virol. 2013 Mar;87(5):2401-11. doi: 10.1128/JVI.02964-12. Epub 2012 Dec 26.
J Virol. 2013.
PMID: 23269796
Free PMC article.
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Kruppel-like factor 2 modulates CCR5 expression and susceptibility to HIV-1 infection.
Richardson MW, Jadlowsky J, Didigu CA, Doms RW, Riley JL.
Richardson MW, et al. Among authors: didigu ca.
J Immunol. 2012 Oct 15;189(8):3815-21. doi: 10.4049/jimmunol.1201431. Epub 2012 Sep 17.
J Immunol. 2012.
PMID: 22988032
Free PMC article.
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