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Antioxidant Activity of Valeriana fauriei Protects against Dexamethasone-Induced Muscle Atrophy.
Kim YI, Lee H, Nirmala FS, Seo HD, Ha TY, Jung CH, Ahn J. Kim YI, et al. Oxid Med Cell Longev. 2022 Jan 12;2022:3645431. doi: 10.1155/2022/3645431. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35069972 Free PMC article.
Valeriana fauriei was also found to act as a reactive oxygen species (ROS) scavenger. Didrovaltrate (DI), an iridoid compound from Valeriana fauriei, was found to downregulate atrophic genes and decrease ROS in the DEX-induced myotube atrophy. ...Further, Valeriana fauriei …
Valeriana fauriei was also found to act as a reactive oxygen species (ROS) scavenger. Didrovaltrate (DI), an iridoid compound from Va …
Effect of didrovaltrate on I-calcium current in rabbit ventricular myocytes.
Xie Q, Li W, Huang Z, Zhang Z. Xie Q, et al. J Tradit Chin Med. 2012 Sep;32(3):442-5. doi: 10.1016/s0254-6272(13)60052-7. J Tradit Chin Med. 2012. PMID: 23297570 Free article.
OBJECTIVE: To investigate the effect of didrovaltrate on L-type calcium current (I(Ca-L)) in rabbit ventricular myocytes. ...Didrovaltrate did not affect the activation curve. CONCLUSION: Didrovaltrate blocks I(Ca-L) in a concentration-dependent manner and pr …
OBJECTIVE: To investigate the effect of didrovaltrate on L-type calcium current (I(Ca-L)) in rabbit ventricular myocytes. ...Didro
A Review Focused on Molecular Mechanisms of Anxiolytic Effect of Valerina officinalis L. in Connection with Its Phytochemistry through in vitro/in vivo Studies.
Orhan IE. Orhan IE. Curr Pharm Des. 2021;27(28):3084-3090. doi: 10.2174/1381612827666210119105254. Curr Pharm Des. 2021. PMID: 33463459 Review.
V. officinalis has complex phytochemistry consisting of the esterified iridoid derivatives known as valepotriates (e.g., valtrate, didrovaltrate, isovalerenic acid), sesquiterpenes (e.g., valerenic acid), flavonoids (e.g., linarin, apigenin), lignans (e.g., pinoresinol, hy …
V. officinalis has complex phytochemistry consisting of the esterified iridoid derivatives known as valepotriates (e.g., valtrate, didrov
Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy.
Lee DH, Park SH, Huh YH, Jung Kim M, Seo HD, Ha TY, Ahn J, Jang YJ, Jung CH. Lee DH, et al. Biomed Pharmacother. 2020 May;125:109950. doi: 10.1016/j.biopha.2020.109950. Epub 2020 Feb 10. Biomed Pharmacother. 2020. PMID: 32058217 Free article.
VFE supplementation reduced fatty liver by downregulating lipogenesis-related genes and increased the autophagy, as revealed by TEM and IHC analysis in the fatty liver. We identified iridoids as main compounds of VFE; didrovaltrate (DI), valeriotriate B (VAL B), valeriotet …
VFE supplementation reduced fatty liver by downregulating lipogenesis-related genes and increased the autophagy, as revealed by TEM and IHC …
Preserved pharmacological activity of hepatocytes-treated extracts of valerian and St. John's wort.
Simmen U, Saladin C, Kaufmann P, Poddar M, Wallimann C, Schaffner W. Simmen U, et al. Planta Med. 2005 Jul;71(7):592-8. doi: 10.1055/s-2005-871262. Planta Med. 2005. PMID: 16041642
The amount of acetoxyvalerenic acid decreased 9-fold, while that of hydroxyvalerenic acid correspondingly increased 9-fold due to O-deacetylation. The valepotriates didrovaltrate, isovaltrate and valtrate decreased 2-, 18- and 16-fold, respectively. ...
The amount of acetoxyvalerenic acid decreased 9-fold, while that of hydroxyvalerenic acid correspondingly increased 9-fold due to O-deacetyl …
Valerian-derived sedative agents. I. On the structure and spectral assignment of the constituents of valmane using the selective INEPT nuclear magnetic resonance technique.
Lin LJ, Cordell GA, Balandrin MF. Lin LJ, et al. Pharm Res. 1991 Sep;8(9):1094-102. doi: 10.1023/a:1015889915326. Pharm Res. 1991. PMID: 1788154
During the course of this work, the "acevaltrate" fraction was shown to be a mixture of 1-alpha-acevaltrate (3) and 7-beta-acevaltrate (4), the structures of valtrate (1) and didrovaltrate (2) were confirmed directly, and two new valepotriates, 5a and 5b, were obtained as …
During the course of this work, the "acevaltrate" fraction was shown to be a mixture of 1-alpha-acevaltrate (3) and 7-beta-acevaltrate (4), …
The Structure of New Valepotriates from Tissue Cultures of Valeriana wallichii.
Becker H, Chavadej S, Thies PW, Firmer E. Becker H, et al. Planta Med. 1984 Jun;50(3):245-8. doi: 10.1055/s-2007-969689. Planta Med. 1984. PMID: 17340305 English, German.
Colchicin-treated tissue cultures of VALERIANA WALLICHII produced besides the known valepotriates homovaltrate, isovaltrate, valtrate, acevaltrate and didrovaltrate several unknown substances of diene-valepotriate structure. ...
Colchicin-treated tissue cultures of VALERIANA WALLICHII produced besides the known valepotriates homovaltrate, isovaltrate, valtrate, aceva …
Effects of thiol compounds versus the cytotoxicity of valepotriates on cultured hepatoma cells.
Keochanthala-Bounthanh C, Haag-Berrurier M, Beck JP, Anton R. Keochanthala-Bounthanh C, et al. Planta Med. 1990 Apr;56(2):190-2. doi: 10.1055/s-2006-960923. Planta Med. 1990. PMID: 2353067
The antagonistic activity of various thiol compounds versus the cytotoxic effects of valtrate and didrovaltrate has been evaluated on cultured hepatoma cells. Compounds with free SH groups like cysteine, mercaptoethanol, dithioerythritol, and glutathione were able to suppr …
The antagonistic activity of various thiol compounds versus the cytotoxic effects of valtrate and didrovaltrate has been evaluated on …
[The synthesis of valperinol and various 3-aminomethyl derivatives of 2,9-dioxatricyclo[4,3,1,0(3,7)]decane from didrovaltrate].
Thies PW, Asai A, Bán I, David S, Finner E. Thies PW, et al. Arzneimittelforschung. 1984;34(11):1460-3. Arzneimittelforschung. 1984. PMID: 6543120 German.
3-Aminomethyl derivatives of 2,9-dioxatricyclo [4,3,1,0(3,7)]decane, can be synthesized via an amination, starting from (1R, 3S, 4S, 6R, 7S, 8R, 10R)-3-iodomethyl-4-acetoxy-8-methoxy-10-methyl-2, 9-dioxatricyclo [4,3,1,0(3,7)]decane or (1R, 3S, 4S, 6R, 7S, 8R)-3-iodomethyl-4-acet …
3-Aminomethyl derivatives of 2,9-dioxatricyclo [4,3,1,0(3,7)]decane, can be synthesized via an amination, starting from (1R, 3S, 4S, 6R, 7S, …
Valepotriate content in different in vitro cultures of Valerianaceae and characterization of Valeriana officinalis L. callus during a growth period.
Violon C, Van Cauwenbergh N, Vercruysse A. Violon C, et al. Pharm Weekbl Sci. 1983 Oct 21;5(5):205-9. doi: 10.1007/BF02332944. Pharm Weekbl Sci. 1983. PMID: 6646985
Different in vitro cultures of Valerianaceae were analysed for valepotriate content [(iso)valtrate, acevaltrate, didrovaltrate] in a study on properties of production in vitro (plant species, growth conditions, differentiation level, valepotriate content of the medium afte …
Different in vitro cultures of Valerianaceae were analysed for valepotriate content [(iso)valtrate, acevaltrate, didrovaltrate] in a …
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