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A flexible, image-based, high-throughput platform encompassing in-depth cell profiling to identify broad-spectrum coronavirus antivirals with limited off-target effects.
Doijen J, Heo I, Temmerman K, Vermeulen P, Diels A, Jaensch S, Burcin M, Van den Broeck N, Raeymaekers V, Peremans J, Konings K, Clement M, Peeters D, Van Loock M, Koul A, Buyck C, Van Gool M, Van Damme E. Doijen J, et al. Among authors: diels a. Antiviral Res. 2024 Feb;222:105789. doi: 10.1016/j.antiviral.2023.105789. Epub 2023 Dec 27. Antiviral Res. 2024. PMID: 38158129 Free article.
Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2.
Doijen J, Temmerman K, Van den Eynde C, Diels A, Van den Broeck N, Van Gool M, Heo I, Jaensch S, Zwaagstra M, Diosa Toro M, Chiu W, De Jonghe S, Leyssen P, Bojkova D, Ciesek S, Cinatl J, Verschueren L, Buyck C, Van Kuppeveld F, Neyts J, Van Loock M, Van Damme E. Doijen J, et al. Among authors: diels a. Microorganisms. 2023 Mar 10;11(3):717. doi: 10.3390/microorganisms11030717. Microorganisms. 2023. PMID: 36985290 Free PMC article.
Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes.
Verheyen A, Diels A, Reumers J, Van Hoorde K, Van den Wyngaert I, van Outryve d'Ydewalle C, De Bondt A, Kuijlaars J, De Muynck L, De Hoogt R, Bretteville A, Jaensch S, Buist A, Cabrera-Socorro A, Wray S, Ebneth A, Roevens P, Royaux I, Peeters PJ. Verheyen A, et al. Among authors: diels a. Stem Cell Reports. 2018 Aug 14;11(2):363-379. doi: 10.1016/j.stemcr.2018.06.022. Epub 2018 Jul 26. Stem Cell Reports. 2018. PMID: 30057263 Free PMC article.
Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes.
Verheyen A, Diels A, Reumers J, Van Hoorde K, Van den Wyngaert I, van Outryve d'Ydewalle C, De Bondt A, Kuijlaars J, De Muynck L, De Hoogt R, Bretteville A, Jaensch S, Buist A, Cabrera-Socorro A, Wray S, Ebneth A, Roevens P, Royaux I, Peeters PJ. Verheyen A, et al. Among authors: diels a. Stem Cell Reports. 2019 Aug 13;13(2):434-435. doi: 10.1016/j.stemcr.2019.07.007. Stem Cell Reports. 2019. PMID: 31412287 Free PMC article. No abstract available.
Using Human iPSC-Derived Neurons to Model TAU Aggregation.
Verheyen A, Diels A, Dijkmans J, Oyelami T, Meneghello G, Mertens L, Versweyveld S, Borgers M, Buist A, Peeters P, Cik M. Verheyen A, et al. Among authors: diels a. PLoS One. 2015 Dec 31;10(12):e0146127. doi: 10.1371/journal.pone.0146127. eCollection 2015. PLoS One. 2015. PMID: 26720731 Free PMC article.
Sustained synchronized neuronal network activity in a human astrocyte co-culture system.
Kuijlaars J, Oyelami T, Diels A, Rohrbacher J, Versweyveld S, Meneghello G, Tuefferd M, Verstraelen P, Detrez JR, Verschuuren M, De Vos WH, Meert T, Peeters PJ, Cik M, Nuydens R, Brône B, Verheyen A. Kuijlaars J, et al. Among authors: diels a. Sci Rep. 2016 Nov 7;6:36529. doi: 10.1038/srep36529. Sci Rep. 2016. PMID: 27819315 Free PMC article.
A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein.
Van Damme E, Abeywickrema P, Yin Y, Xie J, Jacobs S, Mann MK, Doijen J, Miller R, Piassek M, Marsili S, Subramanian M, Gottlieb L, Abdelnabi R, Van Gool M, Van den Broeck N, De Pauw I, Diels A, Vermeulen P, Temmerman K, Scobey T, Mattocks M, Schäfer A, Jochmans D, De Jonghe S, Leyssen P, Chiu W, Diosa Toro M, Zwaagstra M, Leijs AA, De Gruyter HLM, Buyck C, Van Den Heede K, Jacobs F, Van den Eynde C, Thijs L, Raeymaekers V, Miller S, Del Rosario A, Neyts J, Peeters D, Baric RS, van Kuppeveld FJM, Snijder EJ, van Hemert MJ, Monshouwer M, Sharma S, Draghia-Akli R, Koul A, Van Loock M. Van Damme E, et al. Among authors: diels a. Nature. 2025 Apr;640(8058):506-513. doi: 10.1038/s41586-025-08651-6. Epub 2025 Mar 26. Nature. 2025. PMID: 40140563 Free PMC article.
22 results