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Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.
Fonseca BD, Diering GH, Bidinosti MA, Dalal K, Alain T, Balgi AD, Forestieri R, Nodwell M, Rajadurai CV, Gunaratnam C, Tee AR, Duong F, Andersen RJ, Orlowski J, Numata M, Sonenberg N, Roberge M. Fonseca BD, et al. Among authors: diering gh. J Biol Chem. 2012 May 18;287(21):17530-17545. doi: 10.1074/jbc.M112.359638. Epub 2012 Apr 2. J Biol Chem. 2012. PMID: 22474287 Free PMC article.
Regulation of mTORC1 signaling by pH.
Balgi AD, Diering GH, Donohue E, Lam KK, Fonseca BD, Zimmerman C, Numata M, Roberge M. Balgi AD, et al. Among authors: diering gh. PLoS One. 2011;6(6):e21549. doi: 10.1371/journal.pone.0021549. Epub 2011 Jun 29. PLoS One. 2011. PMID: 21738705 Free PMC article.
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