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Page 1
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Rahman OF, Lee SJ, Seeds WA. Rahman OF, et al. J Am Acad Orthop Surg Glob Res Rev. 2026 Jan 2;10(1):e25.00236. doi: 10.5435/JAAOSGlobal-D-25-00236. eCollection 2026 Jan 1. J Am Acad Orthop Surg Glob Res Rev. 2026. PMID: 41490200 Free PMC article. Review.
By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-beta, and AMPK, peptides exert influence over tissue regeneration, inflammation resolution, and neuromuscular recovery. ...Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pine …
By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-beta, and AMPK, peptides exert influence over tissue regeneration, inflam …
The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system.
Benoist CC, Kawas LH, Zhu M, Tyson KA, Stillmaker L, Appleyard SM, Wright JW, Wayman GA, Harding JW. Benoist CC, et al. J Pharmacol Exp Ther. 2014 Nov;351(2):390-402. doi: 10.1124/jpet.114.218735. Epub 2014 Sep 3. J Pharmacol Exp Ther. 2014. Retraction in: J Pharmacol Exp Ther. 2025 Apr;392(4):103567. doi: 10.1016/j.jpet.2025.103567. PMID: 25187433 Free PMC article. Retracted.
Here, we demonstrate that dihexa binds with high affinity to hepatocyte growth factor (HGF) and both dihexa and its parent compound Norleucine 1-AngIV (Nle(1)-AngIV) induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-d …
Here, we demonstrate that dihexa binds with high affinity to hepatocyte growth factor (HGF) and both dihexa and its parent com …
The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease.
Wright JW, Harding JW. Wright JW, et al. J Alzheimers Dis. 2015;45(4):985-1000. doi: 10.3233/JAD-142814. J Alzheimers Dis. 2015. PMID: 25649658 Review.
This growth factor system has recently been shown to induce dendritic arborization and synaptogenesis when stimulated by a newly developed angiotensin-based analogue, N-hexanoic-Tyr-Ile-(6) amino hexanoic amide (Dihexa). This small molecule was derived from the pre-prototy …
This growth factor system has recently been shown to induce dendritic arborization and synaptogenesis when stimulated by a newly developed a …
Dimeric DOTA-alpha-melanocyte-stimulating hormone analogs: synthesis and in vivo characteristics of radiopeptides with high in vitro activity.
Bapst JP, Froidevaux S, Calame M, Tanner H, Eberle AN. Bapst JP, et al. J Recept Signal Transduct Res. 2007;27(5-6):383-409. doi: 10.1080/10799890701723528. J Recept Signal Transduct Res. 2007. PMID: 18097939
The binding activity of DOTA-diHexa(NC-NC)-amide was 1.75-fold higher, that of diHexa(NC-NC)-Gly-Lys(DOTA)-amide was 3.37-fold higher, and that of DOTA-diHexa(CN-NC)-amide was 2.34-fold higher. ...In vivo, however, the data were less promising: tumor-to-kidne …
The binding activity of DOTA-diHexa(NC-NC)-amide was 1.75-fold higher, that of diHexa(NC-NC)-Gly-Lys(DOTA)-amide was 3.37-fold …
Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies.
Ho JK, Nation DA. Ho JK, et al. Neurosci Biobehav Rev. 2018 Sep;92:209-225. doi: 10.1016/j.neubiorev.2018.05.005. Epub 2018 May 4. Neurosci Biobehav Rev. 2018. PMID: 29733881 Free PMC article.
DESIGN: Systematic review of experimental (non-human) studies assessing cognitive effects of RAS peptides angiotensin-(3-8) [Ang IV] and angiotensin-(1-7) [Ang-(1-7)] and their receptors, the Ang IV receptor (AT4R) and the Mas receptor. ...In models of cognitive deficit, e …
DESIGN: Systematic review of experimental (non-human) studies assessing cognitive effects of RAS peptides angiotensin-(3-8) [Ang IV] …
The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases.
Wright JW, Kawas LH, Harding JW. Wright JW, et al. Prog Neurobiol. 2015 Feb;125:26-46. doi: 10.1016/j.pneurobio.2014.11.004. Epub 2014 Nov 29. Prog Neurobiol. 2015. PMID: 25455861 Review.
These research efforts are described along with details concerning a recently synthesized molecule, Dihexa that shows promise in overcoming memory and motor dysfunctions by augmenting synaptic connectivity via the formation of new functional synapses....
These research efforts are described along with details concerning a recently synthesized molecule, Dihexa that shows promise in over …
Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats.
Wells RG, Azzam AF, Hiller AL, Sardinia MF. Wells RG, et al. J Huntingtons Dis. 2024;13(1):55-66. doi: 10.3233/JHD-231507. J Huntingtons Dis. 2024. PMID: 38489193
N-hexanoic-Tyr-Ile-(6)-amino hexanoic amide (PNB-0408), also known as Dihexa, has been shown to have neuroprotective and procognitive properties in animal models of Alzheimer's and Parkinson's diseases. ...
N-hexanoic-Tyr-Ile-(6)-amino hexanoic amide (PNB-0408), also known as Dihexa, has been shown to have neuroprotective and procognitive …
Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy.
Pan T, Wang N, Zhang J, Yang F, Chen Y, Zhuang Y, Xu Y, Fang J, You K, Lin X, Li Y, Li S, Liang K, Li YX, Gao Y. Pan T, et al. Stem Cell Res Ther. 2022 Apr 11;13(1):159. doi: 10.1186/s13287-022-02831-1. Stem Cell Res Ther. 2022. PMID: 35410439 Free PMC article.
Furthermore, we identified that combining Vitamin C, Dihexa, and Forskolin (VDF) could substitute growth factors to induce hepatic specification. ...
Furthermore, we identified that combining Vitamin C, Dihexa, and Forskolin (VDF) could substitute growth factors to induce hepatic sp …
Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.
McCoy AT, Benoist CC, Wright JW, Kawas LH, Bule-Ghogare JM, Zhu M, Appleyard SM, Wayman GA, Harding JW. McCoy AT, et al. J Pharmacol Exp Ther. 2013 Jan;344(1):141-54. doi: 10.1124/jpet.112.199497. Epub 2012 Oct 10. J Pharmacol Exp Ther. 2013. PMID: 23055539 Free PMC article.
Angiotensin IV (AngIV: VYIHPF)-related peptides have long been recognized as procognitive agents with potential as antidementia therapeutics. ...Subsequent chemical modifications, which were designed to increase hydrophobicity and decrease hydrogen bonding, yielded an oral …
Angiotensin IV (AngIV: VYIHPF)-related peptides have long been recognized as procognitive agents with potential as antidementia thera …