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Binding of dihydrodigitoxin to beef and human cardiac (Na+ + K+)-ATPase: evidence for two binding sites in cell membranes.
Brown L, Erdmann E. Brown L, et al. Biochem Pharmacol. 1983 Nov 1;32(21):3183-90. doi: 10.1016/0006-2952(83)90202-2. Biochem Pharmacol. 1983. PMID: 6315020
The dissociation constants (KD-values) calculated from the inhibition of 3H-ouabain binding were: ouabain, 2.9 X 10(-9)M; digitoxin, 1.1 X 10(-9)M; and dihydrodigitoxin 2.7 X 10(-8)M. The concentrations which inhibited beef cardiac (Na+ + K+)-ATPase by 50% were: ouabain, 5 …
The dissociation constants (KD-values) calculated from the inhibition of 3H-ouabain binding were: ouabain, 2.9 X 10(-9)M; digitoxin, 1.1 X 1 …
Enhanced transformation of digitoxin to dihydrodigitoxin in humans with renal failure.
Bodem G, Unruh EV. Bodem G, et al. J Clin Pharmacol. 1979 Apr;19(4):195-9. doi: 10.1002/j.1552-4604.1979.tb01651.x. J Clin Pharmacol. 1979. PMID: 438353
Digitoxin and dihydrodigitoxin were extracted from plasma and derivatized with heptafluorbutyric anhydride. In normal subjects, only minimal concentrations of dihydrodigitoxin in plasma could be determined (1 ng/ml) after an intravenous bolus injection of digitoxin. …
Digitoxin and dihydrodigitoxin were extracted from plasma and derivatized with heptafluorbutyric anhydride. In normal subjects, only …
Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor.
Gupta RS, Chopra A. Gupta RS, et al. Biochem Pharmacol. 1987 Nov 15;36(22):3829-33. doi: 10.1016/0006-2952(87)90445-x. Biochem Pharmacol. 1987. PMID: 2825704
However, these mutants exhibited no cross-resistance to other CG derivatives, which either lacked the above groups (viz. digitoxin, digitoxigenin, dihydrodigitoxin, digitoxigenin mono- and bisdigitoside, nerifolin, gitoxigenin, gitoxin, 16-acetylgitoxin, lanatosides A and …
However, these mutants exhibited no cross-resistance to other CG derivatives, which either lacked the above groups (viz. digitoxin, digitoxi …
Reductive inactivation of digitoxin by Eubacterium lentum cultures.
Chandrasekaran A, Robertson LW, Reuning RH. Chandrasekaran A, et al. Appl Environ Microbiol. 1987 Apr;53(4):901-4. doi: 10.1128/aem.53.4.901-904.1987. Appl Environ Microbiol. 1987. PMID: 3579289 Free PMC article.
The stereochemical configuration at C-20 of the reduction product dihydrodigitoxin was found to be R. Incubation of digitoxigenin and its mono- and bisdigitoxosides individually with E. lentum led to the formation of their respective dihydro derivatives. ...
The stereochemical configuration at C-20 of the reduction product dihydrodigitoxin was found to be R. Incubation of digitoxigenin and …
Pharmacokinetics of dihydrodigitoxin in the cat. A comparison with digitoxin.
Flasch H, Heniz N. Flasch H, et al. Naunyn Schmiedebergs Arch Pharmacol. 1979 Dec;310(2):147-53. doi: 10.1007/BF00500279. Naunyn Schmiedebergs Arch Pharmacol. 1979. PMID: 530320
Blood level data could be described by an open three compartment body model. The biological half-lives of dihydrodigitoxin (DH-DGT) and DGT are rather similar (0.12, 0.48, 20.4 h, and 0.11, 0.43, 31.8 h, respectively), whereas the volume of distribution of DH-DGT is about …
Blood level data could be described by an open three compartment body model. The biological half-lives of dihydrodigitoxin (DH-DGT) a …
Preparation and antigenic properties of digitoxin-bovine serum albumin conjugates linked at the digitoxose C-3' and C-3" positions.
Fujii Y, Ikeda Y, Fujii M, Yamazaki M. Fujii Y, et al. Biol Pharm Bull. 1994 Apr;17(4):467-71. doi: 10.1248/bpb.17.467. Biol Pharm Bull. 1994. PMID: 8069249
Among these antisera, the antiserum raised against digitoxin 3'-hemisuccinate-BSA conjugate possessed high specificity for digitoxin, exhibiting only minor cross-reactions with digitoxigenin bisdigitoxoside (4.0%), dihydrodigitoxin (2.8%), digoxin (2.4%), digitoxigenin mon …
Among these antisera, the antiserum raised against digitoxin 3'-hemisuccinate-BSA conjugate possessed high specificity for digitoxin, exhibi …
The effect of digitalis glycosides-specific antisera on the binding of the glycosides to (Na+ + K+)-ATPase.
Bossaller C. Bossaller C. Arzneimittelforschung. 1981;31(4):625-8. Arzneimittelforschung. 1981. PMID: 6264929
The antisera-induced reversal of the ATPase inhibition caused by digoxin was considerably slower (k-1 = 0.1177 . 10-3 .S-1) than the reversal caused by dihydrodigoxin and dihydrodigitoxin (k-1 = 4.462 . 10-3 . S-1 and K-1 = 3.609 .10-3 . S-1, respectively). ...
The antisera-induced reversal of the ATPase inhibition caused by digoxin was considerably slower (k-1 = 0.1177 . 10-3 .S-1) than the reversa …
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