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Page 1
Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth.
Tocheny CE, Buchwald JE, Dahlke CD, Fakih HH, Morgan JS, Summers A, Silva CA, Jackson SO, Lee JS, Card MA, Echeverria D, Peterson C, Mercurio AM, Khvorova A, Shaw LM. Tocheny CE, et al. Among authors: echeverria d. Mol Ther. 2026 Jan 28:S1525-0016(26)00034-1. doi: 10.1016/j.ymthe.2026.01.033. Online ahead of print. Mol Ther. 2026. PMID: 41612694 Free article.
Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo.
O'Reilly D, Furgal RC, Ross VM, Luu E, Gross KY, Hariharan V, Summers A, Cooper D, Allen S, Dahlke C, Rachid MO, Chan IL, Fakih HH, Alterman JF, Echeverria D, Watts JK, Khvorova A. O'Reilly D, et al. Among authors: echeverria d. Nucleic Acids Res. 2026 Jan 5;54(1):gkaf1438. doi: 10.1093/nar/gkaf1438. Nucleic Acids Res. 2026. PMID: 41521659 Free PMC article.
Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs.
Fakih HH, Lochmann C, Gagnon R, Summers A, Caiazzi J, Buchwald JE, Tang Q, Maru B, Hildebrand SR, Abideen MZUI, Furgal RC, Gross KY, Yang YS, Cooper D, Monopoli KR, Echeverria D, Shim JH, Yamada K, Alterman JF, Khvorova A. Fakih HH, et al. Among authors: echeverria d. Nucleic Acids Res. 2025 Nov 26;53(22):gkaf1374. doi: 10.1093/nar/gkaf1374. Nucleic Acids Res. 2025. PMID: 41432033 Free PMC article.
Cryopreservation of siRNA-Treated Cells Is Feasible.
Sauer M, Segarra-Visent X, Breuer L, Tzirtziganis V, Ryaykenen T, Cooper DA, Echeverria D, Kremer A, Haraszti RA. Sauer M, et al. Among authors: echeverria d. Nucleic Acid Ther. 2025 Dec;35(6):280-285. doi: 10.1177/21593337251381041. Epub 2025 Sep 23. Nucleic Acid Ther. 2025. PMID: 40988558
Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth.
Tocheny CE, Buchwald JE, Dahlke CD, Fakih HH, Morgan JS, Summers A, Wisniewski CA, Jackson SO, Lee JS, Card MA, Echeverria D, Peterson C, Mercurio AM, Khvorova A, Shaw LM. Tocheny CE, et al. Among authors: echeverria d. bioRxiv [Preprint]. 2025 Aug 1:2025.07.29.667434. doi: 10.1101/2025.07.29.667434. bioRxiv. 2025. Update in: Mol Ther. 2026 Jan 28:S1525-0016(26)00034-1. doi: 10.1016/j.ymthe.2026.01.033. PMID: 40766531 Free PMC article. Updated. Preprint.
Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy.
Davis SM, Hildebrand S, MacMillan HJ, Monopoli KR, Buchwald J, Sousa J, Cooper D, Ly S, Echeverria D, McHugh N, Ferguson C, Coles A, Hariharan VN, O'Reilly D, Tang Q, Furgal R, Yamada K, Alterman JF, Gilbert JW, Knox E, Pineda Y, Weston CN, Baer CE, Pai AA, Khvorova A. Davis SM, et al. Among authors: echeverria d. Nucleic Acids Res. 2025 Jun 20;53(12):gkaf479. doi: 10.1093/nar/gkaf479. Nucleic Acids Res. 2025. PMID: 40548938 Free PMC article.
A Therapeutic Small-Interfering RNA Potentiates Janus Kinase 1 Modulation for the Treatment of Dog Inflammatory Diseases.
Tang Q, Fakih HH, Gross KY, Winter SJ, Bramato BM, Yıldız-Altay Ü, Chang BK, Echeverria D, Jackson SO, McHugh N, Srnka A, Alterman JF, Almela RM, Kudej RK, London CA, Richmond JM, Harris JE, Khvorova A. Tang Q, et al. Among authors: echeverria d. ACS Pharmacol Transl Sci. 2025 Mar 24;8(6):1526-1535. doi: 10.1021/acsptsci.4c00594. eCollection 2025 Jun 13. ACS Pharmacol Transl Sci. 2025. PMID: 40534660
72 results