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Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2).
Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF, Taketo MM. Oshima M, et al. Among authors: dinchuk je. Cell. 1996 Nov 29;87(5):803-9. doi: 10.1016/s0092-8674(00)81988-1. Cell. 1996. PMID: 8945508
Multiple female reproductive failures in cyclooxygenase 2-deficient mice.
Lim H, Paria BC, Das SK, Dinchuk JE, Langenbach R, Trzaskos JM, Dey SK. Lim H, et al. Among authors: dinchuk je. Cell. 1997 Oct 17;91(2):197-208. doi: 10.1016/s0092-8674(00)80402-x. Cell. 1997. PMID: 9346237 Free article.
Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.
Dinchuk JE, Car BD, Focht RJ, Johnston JJ, Jaffee BD, Covington MB, Contel NR, Eng VM, Collins RJ, Czerniak PM, et al. Dinchuk JE, et al. Nature. 1995 Nov 23;378(6555):406-9. doi: 10.1038/378406a0. Nature. 1995. PMID: 7477380
Cyclooxygenase-2 is essential for normal recovery from 5-fluorouracil-induced myelotoxicity in mice.
Lorenz M, Slaughter HS, Wescott DM, Carter SI, Schnyder B, Dinchuk JE, Car BD. Lorenz M, et al. Among authors: dinchuk je. Exp Hematol. 1999 Oct;27(10):1494-502. doi: 10.1016/s0301-472x(99)00087-9. Exp Hematol. 1999. PMID: 10517490
P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development.
Garcia RA, Yan M, Search D, Zhang R, Carson NL, Ryan CS, Smith-Monroy C, Zheng J, Chen J, Kong Y, Tang H, Hellings SE, Wardwell-Swanson J, Dinchuk JE, Psaltis GC, Gordon DA, Glunz PW, Gargalovic PS. Garcia RA, et al. Among authors: dinchuk je. PLoS One. 2014 Oct 31;9(10):e111385. doi: 10.1371/journal.pone.0111385. eCollection 2014. PLoS One. 2014. PMID: 25360548 Free PMC article.
Drug safety is a barrier to the discovery and development of new androgen receptor antagonists.
Foster WR, Car BD, Shi H, Levesque PC, Obermeier MT, Gan J, Arezzo JC, Powlin SS, Dinchuk JE, Balog A, Salvati ME, Attar RM, Gottardis MM. Foster WR, et al. Among authors: dinchuk je. Prostate. 2011 Apr;71(5):480-8. doi: 10.1002/pros.21263. Epub 2010 Sep 28. Prostate. 2011. PMID: 20878947
Insulin receptor (IR) pathway hyperactivity in IGF-IR null cells and suppression of downstream growth signaling using the dual IGF-IR/IR inhibitor, BMS-754807.
Dinchuk JE, Cao C, Huang F, Reeves KA, Wang J, Myers F, Cantor GH, Zhou X, Attar RM, Gottardis M, Carboni JM. Dinchuk JE, et al. Endocrinology. 2010 Sep;151(9):4123-32. doi: 10.1210/en.2010-0032. Epub 2010 Jul 7. Endocrinology. 2010. PMID: 20610571
Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin.
Dinchuk JE, Henderson NL, Burn TC, Huber R, Ho SP, Link J, O'Neil KT, Focht RJ, Scully MS, Hollis JM, Hollis GF, Friedman PA. Dinchuk JE, et al. J Biol Chem. 2000 Dec 15;275(50):39543-54. doi: 10.1074/jbc.M006753200. J Biol Chem. 2000. PMID: 10956665 Free article.
Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
Kim S, Dinchuk JE, Anthony MN, Orcutt T, Zoeckler ME, Sauer MB, Mosure KW, Vuppugalla R, Grace JE Jr, Simmermacher J, Dulac HA, Pizzano J, Sinz M. Kim S, et al. Among authors: dinchuk je. Drug Metab Dispos. 2010 Jan;38(1):16-24. doi: 10.1124/dmd.109.029637. Drug Metab Dispos. 2010. PMID: 19833845
Discovery of BMS-641988, a novel and potent inhibitor of androgen receptor signaling for the treatment of prostate cancer.
Attar RM, Jure-Kunkel M, Balog A, Cvijic ME, Dell-John J, Rizzo CA, Schweizer L, Spires TE, Platero JS, Obermeier M, Shan W, Salvati ME, Foster WR, Dinchuk J, Chen SJ, Vite G, Kramer R, Gottardis MM. Attar RM, et al. Cancer Res. 2009 Aug 15;69(16):6522-30. doi: 10.1158/0008-5472.CAN-09-1111. Epub 2009 Aug 4. Cancer Res. 2009. PMID: 19654297
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