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153 results
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The role of Keap1 in cellular protective responses.
Dinkova-Kostova AT, Holtzclaw WD, Kensler TW. Dinkova-Kostova AT, et al. Chem Res Toxicol. 2005 Dec;18(12):1779-91. doi: 10.1021/tx050217c. Chem Res Toxicol. 2005. PMID: 16359168 Review. No abstract available.
Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety.
Soliman AM, Karam HM, Mekkawy MH, Higgins M, Dinkova-Kostova AT, Ghorab MM. Soliman AM, et al. Eur J Med Chem. 2020 Aug 15;200:112467. doi: 10.1016/j.ejmech.2020.112467. Epub 2020 May 18. Eur J Med Chem. 2020. PMID: 32502866 Free PMC article.
The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner.
Zhang Y, Gilmour A, Ahn YH, de la Vega L, Dinkova-Kostova AT. Zhang Y, et al. Phytomedicine. 2019 Aug 5:153062. doi: 10.1016/j.phymed.2019.153062. Online ahead of print. Phytomedicine. 2019. PMID: 31409554
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.
Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P. Dinkova-Kostova AT, et al. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13. doi: 10.1073/pnas.172398899. Epub 2002 Aug 22. Proc Natl Acad Sci U S A. 2002. PMID: 12193649 Free PMC article.
Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis.
Talalay P, Dinkova-Kostova AT, Holtzclaw WD. Talalay P, et al. Adv Enzyme Regul. 2003;43:121-34. doi: 10.1016/s0065-2571(02)00038-9. Adv Enzyme Regul. 2003. PMID: 12791387 Review. No abstract available.
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Wakabayashi N, et al. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5. doi: 10.1073/pnas.0307301101. Epub 2004 Feb 5. Proc Natl Acad Sci U S A. 2004. PMID: 14764894 Free PMC article.
Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates.
Talalay P, Dinkova-Kostova AT. Talalay P, et al. Methods Enzymol. 2004;382:355-64. doi: 10.1016/S0076-6879(04)82019-6. Methods Enzymol. 2004. PMID: 15047111 Review. No abstract available.
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P. Dinkova-Kostova AT, et al. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4584-9. doi: 10.1073/pnas.0500815102. Epub 2005 Mar 14. Proc Natl Acad Sci U S A. 2005. PMID: 15767573 Free PMC article.
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.
Fahey JW, Stephenson KK, Dinkova-Kostova AT, Egner PA, Kensler TW, Talalay P. Fahey JW, et al. Carcinogenesis. 2005 Jul;26(7):1247-55. doi: 10.1093/carcin/bgi068. Epub 2005 Mar 17. Carcinogenesis. 2005. PMID: 15774490
Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.
Dinkova-Kostova AT, Holtzclaw WD, Wakabayashi N. Dinkova-Kostova AT, et al. Biochemistry. 2005 May 10;44(18):6889-99. doi: 10.1021/bi047434h. Biochemistry. 2005. PMID: 15865434
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