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153 results
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Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.
Bensasson RV, Zoete V, Dinkova-Kostova AT, Talalay P. Bensasson RV, et al. Chem Res Toxicol. 2008 Apr;21(4):805-12. doi: 10.1021/tx7002883. Epub 2008 Mar 25. Chem Res Toxicol. 2008. PMID: 18361512
The role of Keap1 in cellular protective responses.
Dinkova-Kostova AT, Holtzclaw WD, Kensler TW. Dinkova-Kostova AT, et al. Chem Res Toxicol. 2005 Dec;18(12):1779-91. doi: 10.1021/tx050217c. Chem Res Toxicol. 2005. PMID: 16359168 Review. No abstract available.
The cytoprotective role of the Keap1-Nrf2 pathway.
Baird L, Dinkova-Kostova AT. Baird L, et al. Arch Toxicol. 2011 Apr;85(4):241-72. doi: 10.1007/s00204-011-0674-5. Epub 2011 Mar 2. Arch Toxicol. 2011. PMID: 21365312 Review.
Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols.
Dinkova-Kostova AT, Wang XJ. Dinkova-Kostova AT, et al. Chem Biol Interact. 2011 Jun 30;192(1-2):101-6. doi: 10.1016/j.cbi.2010.09.010. Epub 2010 Sep 21. Chem Biol Interact. 2011. PMID: 20846517
Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme.
Bensasson RV, Dinkova-Kostova AT, Zheng S, Saito A, Li W, Zoete V, Honda T. Bensasson RV, et al. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4345-9. doi: 10.1016/j.bmcl.2016.07.028. Epub 2016 Jul 15. Bioorg Med Chem Lett. 2016. PMID: 27460172
Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index.
Bensasson RV, Zoete V, Berthier G, Talalay P, Dinkova-Kostova AT. Bensasson RV, et al. Chem Biol Interact. 2010 Jul 30;186(2):118-26. doi: 10.1016/j.cbi.2010.04.026. Epub 2010 Apr 28. Chem Biol Interact. 2010. PMID: 20433811 Free PMC article.
Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital.
Zoete V, Rougée M, Dinkova-Kostova AT, Talalay P, Bensasson RV. Zoete V, et al. Free Radic Biol Med. 2004 Jun 1;36(11):1418-23. doi: 10.1016/j.freeradbiomed.2004.03.008. Free Radic Biol Med. 2004. PMID: 15135178
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P. Dinkova-Kostova AT, et al. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4584-9. doi: 10.1073/pnas.0500815102. Epub 2005 Mar 14. Proc Natl Acad Sci U S A. 2005. PMID: 15767573 Free PMC article.
Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides.
Ghorab MM, Higgins M, Alsaid MS, Arafa RK, Shahat AA, Dinkova-Kostova AT. Ghorab MM, et al. J Enzyme Inhib Med Chem. 2014 Dec;29(6):840-5. doi: 10.3109/14756366.2013.858146. Epub 2014 Jan 14. J Enzyme Inhib Med Chem. 2014. PMID: 24417210
NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives.
Ghorab MM, Alsaid MS, Higgins M, Dinkova-Kostova AT, Shahat AA, Elghazawy NH, Arafa RK. Ghorab MM, et al. Drug Des Devel Ther. 2016 Aug 8;10:2515-24. doi: 10.2147/DDDT.S105423. eCollection 2016. Drug Des Devel Ther. 2016. PMID: 27540279 Free PMC article.
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