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153 results
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Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols.
Dinkova-Kostova AT, Wang XJ. Dinkova-Kostova AT, et al. Chem Biol Interact. 2011 Jun 30;192(1-2):101-6. doi: 10.1016/j.cbi.2010.09.010. Epub 2010 Sep 21. Chem Biol Interact. 2011. PMID: 20846517
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.
Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P. Dinkova-Kostova AT, et al. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13. doi: 10.1073/pnas.172398899. Epub 2002 Aug 22. Proc Natl Acad Sci U S A. 2002. PMID: 12193649 Free PMC article.
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Wakabayashi N, et al. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5. doi: 10.1073/pnas.0307301101. Epub 2004 Feb 5. Proc Natl Acad Sci U S A. 2004. PMID: 14764894 Free PMC article.
The role of Keap1 in cellular protective responses.
Dinkova-Kostova AT, Holtzclaw WD, Kensler TW. Dinkova-Kostova AT, et al. Chem Res Toxicol. 2005 Dec;18(12):1779-91. doi: 10.1021/tx050217c. Chem Res Toxicol. 2005. PMID: 16359168 Review. No abstract available.
Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.
Bensasson RV, Zoete V, Dinkova-Kostova AT, Talalay P. Bensasson RV, et al. Chem Res Toxicol. 2008 Apr;21(4):805-12. doi: 10.1021/tx7002883. Epub 2008 Mar 25. Chem Res Toxicol. 2008. PMID: 18361512
Phytochemicals as protectors against ultraviolet radiation: versatility of effects and mechanisms.
Dinkova-Kostova AT. Dinkova-Kostova AT. Planta Med. 2008 Oct;74(13):1548-59. doi: 10.1055/s-2008-1081296. Epub 2008 Aug 11. Planta Med. 2008. PMID: 18696411 Review.
Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.
Hayes JD, Dinkova-Kostova AT, McMahon M. Hayes JD, et al. Toxicol Sci. 2009 Oct;111(2):199-201. doi: 10.1093/toxsci/kfp168. Epub 2009 Jul 23. Toxicol Sci. 2009. PMID: 19628587 No abstract available.
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.
Chowdhry S, Nazmy MH, Meakin PJ, Dinkova-Kostova AT, Walsh SV, Tsujita T, Dillon JF, Ashford ML, Hayes JD. Chowdhry S, et al. Free Radic Biol Med. 2010 Jan 15;48(2):357-71. doi: 10.1016/j.freeradbiomed.2009.11.007. Epub 2009 Nov 13. Free Radic Biol Med. 2010. PMID: 19914374
Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.
Wang XJ, Hayes JD, Higgins LG, Wolf CR, Dinkova-Kostova AT. Wang XJ, et al. Chem Biol. 2010 Jan 29;17(1):75-85. doi: 10.1016/j.chembiol.2009.12.013. Chem Biol. 2010. PMID: 20142043
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.
Dinkova-Kostova AT, Talalay P. Dinkova-Kostova AT, et al. Arch Biochem Biophys. 2010 Sep 1;501(1):116-23. doi: 10.1016/j.abb.2010.03.019. Epub 2010 Mar 31. Arch Biochem Biophys. 2010. PMID: 20361926 Free PMC article. Review.
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