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146 results

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Page 1
Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV?
Rahfeld J, Schierhorn M, Hartrodt B, Neubert K, Heins J. Rahfeld J, et al. Biochim Biophys Acta. 1991 Jan 29;1076(2):314-6. doi: 10.1016/0167-4838(91)90284-7. Biochim Biophys Acta. 1991. PMID: 1671823
Dipeptidyl peptidase IV preferably hydrolyzes peptides and proteins with a penultimate proline residue. Umezawa and co-workers (Umezawa et al. (1984) J. Antibiotics 37, 422-425) reported that diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) are inhibitor …
Dipeptidyl peptidase IV preferably hydrolyzes peptides and proteins with a penultimate proline residue. Umezawa and co-workers (Umeza …
Diprotin A, an inhibitor of dipeptidyl aminopeptidase IV(EC 3.4.14.5) produces naloxone-reversible analgesia in rats.
Rónai AZ, Timár J, Makó E, Erdö F, Gyarmati Z, Tóth G, Orosz G, Fürst S, Székely JI. Rónai AZ, et al. Life Sci. 1999;64(2):145-52. doi: 10.1016/s0024-3205(98)00544-x. Life Sci. 1999. PMID: 10069492
The action of endomorphin 1 was more potent (ED50 = 7.9 nmol/rat) and slightly but significantly more sustained than that of Diprotin A. Diprotin A neither potentiated nor prolonged the effect of a marginally analgesic dose of endomorphin 1. The distin …
The action of endomorphin 1 was more potent (ED50 = 7.9 nmol/rat) and slightly but significantly more sustained than that of Diprotin …
Dipeptidyl Peptidase 4 Inhibitors Diprotin A and Sitagliptin Administered on Weeks 2-3 of Postnatal Development Modulate Monoamine Metabolism in the Striatum of Adult Rats.
Khlebnikova NN, Orshanskaya EV, Narkevich VB, Kudrin VS, Krupina NA. Khlebnikova NN, et al. Bull Exp Biol Med. 2017 Jun;163(2):190-194. doi: 10.1007/s10517-017-3763-5. Epub 2017 Jul 18. Bull Exp Biol Med. 2017. PMID: 28726205
The levels of monoamines and their metabolites in brain structures of adult (3-month-old) rats with emotional and motivational disorders induced by inhibitors of dipeptidyl peptidase 4 (DPP-4; EC 3.4.14.5) diprotin A and sitagliptin on weeks 2-3 of postnatal develop …
The levels of monoamines and their metabolites in brain structures of adult (3-month-old) rats with emotional and motivational disorders ind …
The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A.
Hiramatsu H, Yamamoto A, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Shimizu R. Hiramatsu H, et al. Biol Chem. 2004 Jun;385(6):561-4. doi: 10.1515/BC.2004.068. Biol Chem. 2004. PMID: 15255191
In order to elucidate the binding mode and substrate specificity, we determined the crystal structure complex of hDPPIV and diprotin A (IIe-Pro-IIe), a slowly hydrolyzed substrate of hDPPIV, at 2.2 A resolution. In this paper, we discuss the molecular interaction me …
In order to elucidate the binding mode and substrate specificity, we determined the crystal structure complex of hDPPIV and diprotin …
Similarity and dissimilarity in antinociceptive effects of dipeptidyl-peptidase 4 inhibitors, Diprotin A and vildagliptin in rat inflammatory pain models following spinal administration.
Balogh M, Varga BK, Karádi DÁ, Riba P, Puskár Z, Kozsurek M, Al-Khrasani M, Király K. Balogh M, et al. Brain Res Bull. 2019 Apr;147:78-85. doi: 10.1016/j.brainresbull.2019.02.001. Epub 2019 Feb 7. Brain Res Bull. 2019. PMID: 30738866
The present study investigated the effects of intrathecal (it.) diprotin A and vildagliptin in Complete Freund's Adjuvant- (CFA) and formalin induced pain in rats. ...In conclusion, diprotin A and vildagliptin display antinociception of different mecha …
The present study investigated the effects of intrathecal (it.) diprotin A and vildagliptin in Complete Freund's Adjuvant- (CF …
Understanding the molecular dynamics of type-2 diabetes drug target DPP-4 and its interaction with Sitagliptin and inhibitor Diprotin-A.
Chakraborty C, Hsu MJ, Agoramoorthy G. Chakraborty C, et al. Cell Biochem Biophys. 2014 Nov;70(2):907-22. doi: 10.1007/s12013-014-9998-0. Cell Biochem Biophys. 2014. PMID: 24809328
The occurrence of type 2 diabetes (T2D) accounts for 90-95 % of all diabetes. Intestine hormone glucagon-like peptide-1 (GLP-1) has an antidiabetic role that enhances insulin secretion and pancreatic beta-cell proliferation. ...Hence, the DPP-4 inhibition has been preferre …
The occurrence of type 2 diabetes (T2D) accounts for 90-95 % of all diabetes. Intestine hormone glucagon-like peptide-1 (GLP-1) has a …
The effects of endomorphins and diprotin A on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study in rats.
Bagosi Z, Jászberényi M, Bujdosó E, Szabó G, Telegdy G. Bagosi Z, et al. Neurochem Int. 2006 Dec;49(7):665-8. doi: 10.1016/j.neuint.2006.05.006. Epub 2006 Jul 3. Neurochem Int. 2006. PMID: 16815593
EM2 was effective only when the slices were pretreated with diprotin A. beta-Funaltrexamine antagonized the stimulatory effects of both EM1 and EM2. The administration of naloxonazine did not appreciably influence the action of EM1, but blocked the action of EM2, at …
EM2 was effective only when the slices were pretreated with diprotin A. beta-Funaltrexamine antagonized the stimulatory effect …
[Emotional Motivational Disorders in Rats as a Result of Diprotin A and Sitagliptin Administration in the First Postnatal Week].
Krupina NA, Khlebnikova NN, Orlova IN. Krupina NA, et al. Zh Vyssh Nerv Deiat Im I P Pavlova. 2016 May;66(3):367-381. Zh Vyssh Nerv Deiat Im I P Pavlova. 2016. PMID: 30695419 Russian.
In adult rats, diprotin A caused an increase in anxiety according to the reduced pref- erence for open arms of the maze and both the inhibitors decreased the percentage of rats entering open. arms in the EPM. Adult diprotin A-treated animals demonstrat …
In adult rats, diprotin A caused an increase in anxiety according to the reduced pref- erence for open arms of the maze and bo …
Effect of Diprotin A, an Inhibitor of Dipeptidyl Peptidase IV, on Immunological Parameters of Lymphocytes in Intact Animals and Animals with Experimental Autoimmune Process.
Robinson MV, Mel'nikova EV, Trufakin VA. Robinson MV, et al. Bull Exp Biol Med. 2015 Apr;158(6):769-71. doi: 10.1007/s10517-015-2858-0. Epub 2015 Apr 21. Bull Exp Biol Med. 2015. PMID: 25894775
We found the peculiarities of the effects of dipeptidyl peptidase IV inhibitor diprotin A on immunological parameters of lymphocytes in lymphoid organs in intact animals and in animals with experimental autoimmune process. In intact animals, diprotin A …
We found the peculiarities of the effects of dipeptidyl peptidase IV inhibitor diprotin A on immunological parameters of lymph …
Diprotin A infusion into nonobese diabetic/severe combined immunodeficiency mice markedly enhances engraftment of human mobilized CD34+ peripheral blood cells.
Kawai T, Choi U, Liu PC, Whiting-Theobald NL, Linton GF, Malech HL. Kawai T, et al. Stem Cells Dev. 2007 Jun;16(3):361-70. doi: 10.1089/scd.2007.9997. Stem Cells Dev. 2007. PMID: 17610366
We show that injection of irradiated nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice with >or=2 micromol Diprotin A (a tripeptide specific inhibitor of CD26 protease activity) at the time of transplant of human granulocyte colony-stimulating fa …
We show that injection of irradiated nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice with >or=2 micromol Diprotin …
146 results