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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 2
1994 1
1995 2
1996 1
1997 2
1998 2
1999 1
2001 3
2004 2
2005 1
2011 1
2020 3
2021 0
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Page 1
Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.
Sivaprakasam P, Wang Z, Meanwell NA, Khan JA, Langley DR, Johnson SR, Li G, Pendri A, Connolly TP, Gao M, Camac DM, Klakouski C, Zvyaga T, Cianci C, McAuliffe B, Ding B, Discotto L, Krystal MR, Jenkins S, Peese KM, Narasimhulu Naidu B. Sivaprakasam P, et al. Among authors: discotto l. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127531. doi: 10.1016/j.bmcl.2020.127531. Epub 2020 Sep 2. Bioorg Med Chem Lett. 2020. PMID: 32890685
Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
Li G, Meanwell NA, Krystal MR, Langley DR, Naidu BN, Sivaprakasam P, Lewis H, Kish K, Khan JA, Ng A, Trainor GL, Cianci C, Dicker IB, Walker MA, Lin Z, Protack T, Discotto L, Jenkins S, Gerritz SW, Pendri A. Li G, et al. Among authors: discotto l. J Med Chem. 2020 Mar 12;63(5):2620-2637. doi: 10.1021/acs.jmedchem.9b01681. Epub 2020 Feb 21. J Med Chem. 2020. PMID: 32081010
Staphylococcus aureus mutants selected by BMS-284756.
Discotto LF, Lawrence LE, Denbleyker KL, Barrett JF. Discotto LF, et al. Antimicrob Agents Chemother. 2001 Nov;45(11):3273-5. doi: 10.1128/AAC.45.11.3273-3275.2001. Antimicrob Agents Chemother. 2001. PMID: 11600399 Free PMC article.
Bacterial resistance.
Lawrence LE, Pucci MJ, Discotto L, Barrett JF. Lawrence LE, et al. Among authors: discotto l. IDrugs. 1998 Dec;1(8):850-9. IDrugs. 1998. PMID: 16196471 No abstract available.
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Gerritz SW, Cianci C, Kim S, Pearce BC, Deminie C, Discotto L, McAuliffe B, Minassian BF, Shi S, Zhu S, Zhai W, Pendri A, Li G, Poss MA, Edavettal S, McDonnell PA, Lewis HA, Maskos K, Mörtl M, Kiefersauer R, Steinbacher S, Baldwin ET, Metzler W, Bryson J, Healy MD, Philip T, Zoeckler M, Schartman R, Sinz M, Leyva-Grado VH, Hoffmann HH, Langley DR, Meanwell NA, Krystal M. Gerritz SW, et al. Among authors: discotto l. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15366-71. doi: 10.1073/pnas.1107906108. Epub 2011 Sep 6. Proc Natl Acad Sci U S A. 2011. PMID: 21896751 Free PMC article.
Atazanavir signature I50L resistance substitution accounts for unique phenotype of increased susceptibility to other protease inhibitors in a variety of human immunodeficiency virus type 1 genetic backbones.
Weinheimer S, Discotto L, Friborg J, Yang H, Colonno R. Weinheimer S, et al. Among authors: discotto l. Antimicrob Agents Chemother. 2005 Sep;49(9):3816-24. doi: 10.1128/AAC.49.9.3816-3824.2005. Antimicrob Agents Chemother. 2005. PMID: 16127058 Free PMC article.
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