Discovery and refinement of loci associated with lipid levels.
Nat Genet. 2013.
PMID: 24097068
Free PMC article.
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Discovery and refinement of loci associated with lipid levels.
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Isaacs A, Jackson AU, Johansson Å, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikäinen LP, Magnusson PKE, Mangino M, Mihailov E, Montasser ME, Müller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney ASF, Döring A, Elliott P, Epstein SE, Ingi Eyjolfsson G, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Leh…
See abstract for full author list ➔
Willer CJ, et al.
Nat Genet. 2013 Nov;45(11):1274-1283. doi: 10.1038/ng.2797. Epub 2013 Oct 6.
Nat Genet. 2013.
PMID: 24097068
Free PMC article.
We identify and annotate 157 loci associated with lipid levels at P < 5 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South
…We identify and annotate 157 loci associated with lipid levels at P < 5 10(-8), including 62 loci not
…
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Translating genetic association of lipid levels for biological and clinical application.
Crone B, Krause AM, Hornsby WE, Willer CJ, Surakka I.
Crone B, et al.
Cardiovasc Drugs Ther. 2021 Jun;35(3):617-626. doi: 10.1007/s10557-021-07156-4. Epub 2021 Feb 19.
Cardiovasc Drugs Ther. 2021.
PMID: 33604704
Free PMC article.
Review.
RECENT FINDINGS: Current lipid genetics research aims to understand the association mechanisms and clinical relevance of lipid loci as well as to capture population specific associations found in global ancestries. Recent genome-wide trans-ethni …
RECENT FINDINGS: Current lipid genetics research aims to understand the association mechanisms and clinical relevance of li …
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From lipid locus to drug target through human genomics.
van der Laan SW, Harshfield EL, Hemerich D, Stacey D, Wood AM, Asselbergs FW.
van der Laan SW, et al.
Cardiovasc Res. 2018 Jul 15;114(9):1258-1270. doi: 10.1093/cvr/cvy120.
Cardiovasc Res. 2018.
PMID: 29800275
Review.
In the last decade, over 175 genetic loci have robustly been associated to levels of major circulating blood lipids. Most loci are specific to one or two lipids, whereas some (SUGP1, ZPR1, TRIB1, HERPUD1, and FADS1) are associated …
In the last decade, over 175 genetic loci have robustly been associated to levels of major circulating blood lipids …
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