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Neural Correlates of Schizophrenia Negative Symptoms: Distinct Subtypes Impact Dissociable Brain Circuits.
Shaffer JJ, Peterson MJ, McMahon MA, Bizzell J, Calhoun V, van Erp TG, Ford JM, Lauriello J, Lim KO, Manoach DS, McEwen SC, Mathalon DH, O'Leary D, Potkin SG, Preda A, Turner J, Voyvodic J, Wible CG, Belger A. Shaffer JJ, et al. Mol Neuropsychiatry. 2015 Dec;1(4):191-200. doi: 10.1159/000440979. Epub 2015 Oct 17. Mol Neuropsychiatry. 2015. PMID: 27606313 Free PMC article.
RESULTS: The severity of alogia, avolition/apathy and anhedonia/asociality was negatively correlated with BOLD activity in distinct sets of brain regions associated with processing of the target tone, including basal ganglia, thalamus, insular cortex, prefrontal cor …
RESULTS: The severity of alogia, avolition/apathy and anhedonia/asociality was negatively correlated with BOLD activity in distinct s …
Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction.
Pittman-Polletta B, Hu K, Kocsis B. Pittman-Polletta B, et al. Sci Rep. 2018 Aug 2;8(1):11588. doi: 10.1038/s41598-018-29331-8. Sci Rep. 2018. PMID: 30072757 Free PMC article.
This study examined the impact of subtype-specific NMDAR antagonism on HFOs and PAC. We found that positive-symptom-associated NR2A-preferring antagonism (NVP-AAM077), but not NR2B-specific antagonism (Ro25-6985) or saline control, replicated increases in HFO power …
This study examined the impact of subtype-specific NMDAR antagonism on HFOs and PAC. We found that positive-symptom-associated …
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