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Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy.
Katsumata Y, Abner EL, Karanth S, Teylan MA, Mock CN, Cykowski MD, Lee EB, Boehme KL, Mukherjee S, Kauwe JSK, Kryscio RJ, Schmitt FA, Fardo DW, Nelson PT. Katsumata Y, et al. Acta Neuropathol. 2020 Nov;140(5):659-674. doi: 10.1007/s00401-020-02211-0. Epub 2020 Aug 14. Acta Neuropathol. 2020. PMID: 32797255 Free PMC article.
Subjects in Cluster 2 had a relatively slow cognitive decline. Subjects in both Clusters 3 and 4 had severe ADNC + LATE-NC; however, Cluster 4 was distinguished by earlier disease onset, swifter disease course, more Lewy body pathology, less neocortical TD
Subjects in Cluster 2 had a relatively slow cognitive decline. Subjects in both Clusters 3 and 4 had severe ADNC + LATE-NC; ho …
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.
Mackenzie IR, Frick P, Grässer FA, Gendron TF, Petrucelli L, Cashman NR, Edbauer D, Kremmer E, Prudlo J, Troost D, Neumann M. Mackenzie IR, et al. Acta Neuropathol. 2015 Dec;130(6):845-61. doi: 10.1007/s00401-015-1476-2. Epub 2015 Sep 15. Acta Neuropathol. 2015. PMID: 26374446
Therefore, we performed a systematic clinico-pathological correlative analysis with counting of actual numbers of distinct types of inclusion (neuronal cytoplasmic and intranuclear inclusions, dystrophic neurites) for each DPR protein in relevant brain regions (prem …
Therefore, we performed a systematic clinico-pathological correlative analysis with counting of actual numbers of distinct typ …