Distinct sets of genetic alterations in melanoma.
N Engl J Med. 2005.
PMID: 16291983
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Distinct sets of genetic alterations in melanoma.
N Engl J Med. 2005 Nov 17;353(20):2135-47. doi: 10.1056/NEJMoa050092.
N Engl J Med. 2005.
PMID: 16291983
Free article.
BACKGROUND: Exposure to ultraviolet light is a major causative factor in melanoma, although the relationship between risk and exposure is complex. We hypothesized that the clinical heterogeneity is explained by genetically distinct types of melanoma wi …
BACKGROUND: Exposure to ultraviolet light is a major causative factor in melanoma, although the relationship between risk and exposur …
NF1 and Neurofibromin: Emerging Players in the Genetic Landscape of Desmoplastic Melanoma.
Adv Anat Pathol. 2017 Jan;24(1):1-14. doi: 10.1097/PAP.0000000000000131.
Adv Anat Pathol. 2017.
PMID: 27941538
Review.
More recently, much attention has focused on the role of NF1 and neurofibromin in melanoma as mutations in NF1 have been found to constitute 1 of the 4 distinct genomic categories of melanoma, with the other 3 comprising BRAF, NRAS, and "triple-wild-type" sub …
More recently, much attention has focused on the role of NF1 and neurofibromin in melanoma as mutations in NF1 have been found to con …
MicroRNA heterogeneity in melanoma progression.
Semin Cancer Biol. 2019 Dec;59:208-220. doi: 10.1016/j.semcancer.2019.05.021. Epub 2019 Jun 1.
Semin Cancer Biol. 2019.
PMID: 31163254
Free PMC article.
Review.
The altered expression of miRNAs has been linked with neocarcinogenesis or the development of human malignancies including melanoma. Of significance, multiple clinical studies have documented that distinct sets of microRNAs (miRNAs) could be utilized a …
The altered expression of miRNAs has been linked with neocarcinogenesis or the development of human malignancies including melanom …
Genetic drivers of non-cutaneous melanomas: Challenges and opportunities in a heterogeneous landscape.
Exp Dermatol. 2022 Jan;31(1):13-30. doi: 10.1111/exd.14287. Epub 2021 Feb 1.
Exp Dermatol. 2022.
PMID: 33455025
Review.
Within ocular melanomas, posterior uveal tract melanomas typically harbour one of two distinct, sets of driver mutations and alterations of clinical and biological significance. ...The genetic drivers in iris melanomas more closely …
Within ocular melanomas, posterior uveal tract melanomas typically harbour one of two distinct, sets of driver m …
Gene Network Rewiring to Study Melanoma Stage Progression and Elements Essential for Driving Melanoma.
PLoS One. 2015 Nov 11;10(11):e0142443. doi: 10.1371/journal.pone.0142443. eCollection 2015.
PLoS One. 2015.
PMID: 26558755
Free PMC article.
Metastatic melanoma patients have a poor prognosis, mainly attributable to the underlying heterogeneity in melanoma driver genes and altered gene expression profiles. ...We meta-analysed 642 microarray samples to generate melanoma reconstructed network …
Metastatic melanoma patients have a poor prognosis, mainly attributable to the underlying heterogeneity in melanoma driver gen …
Fluorescence in situ hybridisation as an ancillary tool in the diagnosis of acral melanoma: a review of 44 cases.
Pathology. 2017 Dec;49(7):740-749. doi: 10.1016/j.pathol.2017.08.006. Epub 2017 Oct 14.
Pathology. 2017.
PMID: 29037804
Review.
Acral melanoma is associated with outcomes which are more unfavourable than those of other melanoma subtypes, and acral melanoma has higher mortality. However, histological distinction of acral melanoma from acral naevi may be difficult. Fluores …
Acral melanoma is associated with outcomes which are more unfavourable than those of other melanoma subtypes, and acral mel …
Use of gene expression and pathway signatures to characterize the complexity of human melanoma.
Am J Pathol. 2011 Jun;178(6):2513-22. doi: 10.1016/j.ajpath.2011.02.037.
Am J Pathol. 2011.
PMID: 21641377
Free PMC article.
Unsupervised hierarchical clustering, gene set enrichment analyses, and pathway activity analyses were used to describe the genetic heterogeneity of melanomas. Patterns of gene expression that revealed two distinct classes of primary melanoma, two d …
Unsupervised hierarchical clustering, gene set enrichment analyses, and pathway activity analyses were used to describe the genetic h …
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene. 2007 Jul 12;26(32):4738-48. doi: 10.1038/sj.onc.1210252. Epub 2007 Jan 29.
Oncogene. 2007.
PMID: 17260012
Distinct copy number alterations were detected, including loss or gain of whole chromosomes but also minute amplifications and homozygous deletions. ...Moreover, alterations of the various melanoma genes were associated with distinct chromosomal …
Distinct copy number alterations were detected, including loss or gain of whole chromosomes but also minute amplifications and …
Transforming growth factor-beta activation promotes genetic context-dependent invasion of immortalized melanocytes.
Cancer Res. 2008 Jun 1;68(11):4248-57. doi: 10.1158/0008-5472.CAN-07-5671.
Cancer Res. 2008.
PMID: 18519684
Accumulation of distinct sets of genetic/epigenetic alterations is thought to contribute to stepwise progression of human cutaneous melanomas. ...Evidence of genetic interactions among PTEN deficiency, Braf activation, and cell autonomous …
Accumulation of distinct sets of genetic/epigenetic alterations is thought to contribute to stepwise progression …
"Lineage addiction" in human cancer: lessons from integrated genomics.
Cold Spring Harb Symp Quant Biol. 2005;70:25-34. doi: 10.1101/sqb.2005.70.016.
Cold Spring Harb Symp Quant Biol. 2005.
PMID: 16869735
Clustering analyses of SNP array data from a large collection of tumor samples and cell lines suggest that certain copy number alterations correlate strongly with the tissue of origin. Such lineage-restricted alterations may harbor novel cancer genes directing genes …
Clustering analyses of SNP array data from a large collection of tumor samples and cell lines suggest that certain copy number alteration …
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