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Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder.
Lipstein N, Verhoeven-Duif NM, Michelassi FE, Calloway N, van Hasselt PM, Pienkowska K, van Haaften G, van Haelst MM, van Empelen R, Cuppen I, van Teeseling HC, Evelein AM, Vorstman JA, Thoms S, Jahn O, Duran KJ, Monroe GR, Ryan TA, Taschenberger H, Dittman JS, Rhee JS, Visser G, Jans JJ, Brose N. Lipstein N, et al. Among authors: dittman js. J Clin Invest. 2017 Mar 1;127(3):1005-1018. doi: 10.1172/JCI90259. Epub 2017 Feb 13. J Clin Invest. 2017. PMID: 28192369 Free PMC article.
Synaptic vesicles position complexin to block spontaneous fusion.
Wragg RT, Snead D, Dong Y, Ramlall TF, Menon I, Bai J, Eliezer D, Dittman JS. Wragg RT, et al. Among authors: dittman js. Neuron. 2013 Jan 23;77(2):323-34. doi: 10.1016/j.neuron.2012.11.005. Neuron. 2013. PMID: 23352168 Free PMC article.
A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.
Padmanarayana M, Liu H, Michelassi F, Li L, Betensky D, Dominguez MJ, Sutton RB, Hu Z, Dittman JS. Padmanarayana M, et al. Among authors: dittman js. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2016276118. doi: 10.1073/pnas.2016276118. Proc Natl Acad Sci U S A. 2021. PMID: 33836576 Free PMC article.
72 results