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The TSG101 protein binds to connexins and is involved in connexin degradation.
Auth T, Schlüter S, Urschel S, Kussmann P, Sonntag S, Höher T, Kreuzberg MM, Dobrowolski R, Willecke K. Auth T, et al. Among authors: dobrowolski r. Exp Cell Res. 2009 Apr 1;315(6):1053-62. doi: 10.1016/j.yexcr.2008.12.025. Epub 2009 Jan 13. Exp Cell Res. 2009. PMID: 19210987
The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice.
Lübkemeier I, Andrié R, Lickfett L, Bosen F, Stöckigt F, Dobrowolski R, Draffehn AM, Fregeac J, Schultze JL, Bukauskas FF, Schrickel JW, Willecke K. Lübkemeier I, et al. Among authors: dobrowolski r. J Mol Cell Cardiol. 2013 Dec;65:19-32. doi: 10.1016/j.yjmcc.2013.09.008. Epub 2013 Sep 21. J Mol Cell Cardiol. 2013. PMID: 24060583
Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels.
Lübkemeier I, Requardt RP, Lin X, Sasse P, Andrié R, Schrickel JW, Chkourko H, Bukauskas FF, Kim JS, Frank M, Malan D, Zhang J, Wirth A, Dobrowolski R, Mohler PJ, Offermanns S, Fleischmann BK, Delmar M, Willecke K. Lübkemeier I, et al. Among authors: dobrowolski r. Basic Res Cardiol. 2013 May;108(3):348. doi: 10.1007/s00395-013-0348-y. Epub 2013 Apr 5. Basic Res Cardiol. 2013. PMID: 23558439 Free PMC article.
The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans.
Dobrowolski R, Sasse P, Schrickel JW, Watkins M, Kim JS, Rackauskas M, Troatz C, Ghanem A, Tiemann K, Degen J, Bukauskas FF, Civitelli R, Lewalter T, Fleischmann BK, Willecke K. Dobrowolski R, et al. Hum Mol Genet. 2008 Feb 15;17(4):539-54. doi: 10.1093/hmg/ddm329. Epub 2007 Nov 13. Hum Mol Genet. 2008. PMID: 18003637 Free PMC article.
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