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Nerve growth factor blocks the glucose-induced down-regulation of caveolin-1 expression in Schwann cells via p75 neurotrophin receptor signaling.
Tan W, Rouen S, Barkus KM, Dremina YS, Hui D, Christianson JA, Wright DE, Yoon SO, Dobrowsky RT. Tan W, et al. J Biol Chem. 2003 Jun 20;278(25):23151-62. doi: 10.1074/jbc.M212986200. Epub 2003 Apr 5. J Biol Chem. 2003. PMID: 12679365
Coupling of the p75 neurotrophin receptor to sphingolipid signaling.
Dobrowsky RT, Carter BD. Dobrowsky RT, et al. Ann N Y Acad Sci. 1998 Jun 19;845:32-45. doi: 10.1111/j.1749-6632.1998.tb09660.x. Ann N Y Acad Sci. 1998. PMID: 9668341 Review.
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor.
Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA. Dobrowsky RT, et al. Science. 1994 Sep 9;265(5178):1596-9. doi: 10.1126/science.8079174. Science. 1994. PMID: 8079174
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids.
Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA. Chavez JA, et al. J Biol Chem. 2003 Mar 21;278(12):10297-303. doi: 10.1074/jbc.M212307200. Epub 2003 Jan 13. J Biol Chem. 2003. PMID: 12525490
KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability.
Farmer K, Williams SJ, Novikova L, Ramachandran K, Rawal S, Blagg BS, Dobrowsky R, Stehno-Bittel L. Farmer K, et al. Exp Diabetes Res. 2012;2012:671673. doi: 10.1155/2012/671673. Epub 2012 Nov 1. Exp Diabetes Res. 2012. PMID: 23197975 Free PMC article.
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