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Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate beta-semialdehyde.
Dobson RC, Gerrard JA, Pearce FG. Dobson RC, et al. Biochem J. 2004 Feb 1;377(Pt 3):757-62. doi: 10.1042/BJ20031389. Biochem J. 2004. PMID: 14580236 Free PMC article.
The preparation of (S)-aspartate semi-aldehyde appropriate for use in biochemical studies.
Roberts SJ, Morris JC, Dobson RC, Gerrard JA. Roberts SJ, et al. Among authors: dobson rc. Bioorg Med Chem Lett. 2003 Jan 20;13(2):265-7. doi: 10.1016/s0960-894x(02)00923-x. Bioorg Med Chem Lett. 2003. PMID: 12482436
The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad.
Dobson RC, ValegÄrd K, Gerrard JA. Dobson RC, et al. J Mol Biol. 2004 Apr 23;338(2):329-39. doi: 10.1016/j.jmb.2004.02.060. J Mol Biol. 2004. PMID: 15066435
Dihydrodipicolinate synthase (DHDPS) from Escherichia coli displays partial mixed inhibition with respect to its first substrate, pyruvate.
Dobson RC, Griffin MD, Roberts SJ, Gerrard JA. Dobson RC, et al. Biochimie. 2004 Apr-May;86(4-5):311-5. doi: 10.1016/j.biochi.2004.03.008. Biochimie. 2004. PMID: 15194235
Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate.
Turner JJ, Healy JP, Dobson RC, Gerrard JA, Hutton CA. Turner JJ, et al. Among authors: dobson rc. Bioorg Med Chem Lett. 2005 Feb 15;15(4):995-8. doi: 10.1016/j.bmcl.2004.12.043. Bioorg Med Chem Lett. 2005. PMID: 15686899
The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance.
Dobson RC, Griffin MD, Jameson GB, Gerrard JA. Dobson RC, et al. Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1116-24. doi: 10.1107/S0907444905016318. Epub 2005 Jul 20. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 16041077
Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase.
Dobson RC, Devenish SR, Turner LA, Clifford VR, Pearce FG, Jameson GB, Gerrard JA. Dobson RC, et al. Biochemistry. 2005 Oct 4;44(39):13007-13. doi: 10.1021/bi051281w. Biochemistry. 2005. PMID: 16185069
Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?
Mitsakos V, Dobson RC, Pearce FG, Devenish SR, Evans GL, Burgess BR, Perugini MA, Gerrard JA, Hutton CA. Mitsakos V, et al. Among authors: dobson rc. Bioorg Med Chem Lett. 2008 Jan 15;18(2):842-4. doi: 10.1016/j.bmcl.2007.11.026. Epub 2007 Nov 13. Bioorg Med Chem Lett. 2008. PMID: 18054225
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.
Kefala G, Evans GL, Griffin MD, Devenish SR, Pearce FG, Perugini MA, Gerrard JA, Weiss MS, Dobson RC. Kefala G, et al. Among authors: dobson rc. Biochem J. 2008 Apr 15;411(2):351-60. doi: 10.1042/BJ20071360. Biochem J. 2008. PMID: 18062777
Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.
Boughton BA, Dobson RC, Gerrard JA, Hutton CA. Boughton BA, et al. Among authors: dobson rc. Bioorg Med Chem Lett. 2008 Jan 15;18(2):460-3. doi: 10.1016/j.bmcl.2007.11.108. Epub 2007 Dec 3. Bioorg Med Chem Lett. 2008. PMID: 18077163
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